FS laser processing of bio-polymer thin films for studying cell-to-substrate specific response

Daskalova, A.; Nathala, Chandra Sekher; Kavatzikidou, Paraskevi; Ranella, Anthi; Szoszkiewicz, Robert; Husinsky, W.; Fotakis, C.

doi:10.1016/j.apsusc.2016.04.134

Cited by 19 publications

(16 citation statements)

References 45 publications

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“…In practical applications, especially in the fields of biomedicine and tissue engineering, surface modification is an indispensable process to improve the compatibility or biocompatibility of biomaterials. Femtosecond laser processing is a common surface pattern and construction technology [86,87]. For example, the surface is modified through producing grooves and micropores on the polylactic acid micropore structure prepared by 3D fused wire, so as to enhance the functionalization ability of the implant material.…”

Section: Ptfe and Significantly Improves The Adhesion And Morphology mentioning

confidence: 99%

Recent advance in surface modification for regulating cell adhesion and behaviors

Cai

Yang

et al. 2020

Nanotechnology Reviews

417

247

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Cell adhesion is a basic requirement for anchorage-dependent cells to survive on the matrix. It is the first step in a series of cell activities, such as cell diffusion, migration, proliferation, and differentiation. In vivo, cells are surrounded by extracellular matrix (ECM), whose physical and biochemical properties and micromorphology may affect and regulate the function and behavior of cells, causing cell reactions. Cell adhesion is also the basis of communication between cells and the external environment and plays an important role in tissue development. Therefore, the significance of studying cell adhesion in vitro has become increasingly prominent. For instance, in the field of tissue engineering and regenerative medicine, researchers have used artificial surfaces of different materials to simulate the properties of natural ECM, aiming to regulate the behavior of cell adhesion. Understanding the factors that affect cell behavior and how to control cell behavior, including cell adhesion, orientation, migration, and differentiation on artificial surfaces, is essential for materials and life sciences, such as advanced biomedical engineering and tissue engineering. This article reviews various factors affecting cell adhesion as well as the methods and materials often used in investigating cell adhesion.

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Section: Ptfe and Significantly Improves The Adhesion And Morphology mentioning

confidence: 99%

Recent advance in surface modification for regulating cell adhesion and behaviors

Cai

Yang

et al. 2020

Nanotechnology Reviews

417

247

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“…Ultrashort pulse lasers are frequently used for polymer surface structuring in bioengineering applications. There are several reports on the influence of surface topography and chemistry after laser ablation on cell response to the substrate in case of collagen/elastin blends and gelatin 3 , polyurethane/poly(lactic-co-glycolic acid)/polylacide-polyethylene glycol-polylactide (PU:PLGA:PPP) blends 4 , PLLA and polystyrene (PS) 5 , PLLA/hydroxyapatite (PLLA/HAp) composite 6 . The possibility of nanostructuring of PLLA surface by femtosecond laser-induced self-organized periodic structures was presented lately 7 .…”

Section: Introductionmentioning

confidence: 99%

Diverse nature of femtosecond laser ablation of poly(L-lactide) and the influence of filamentation on the polymer crystallization behaviour

Stępak

Gazińska

Nejbauer

et al. 2019

Sci Rep

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Over the past few years we have witnessed growing interest in ultrafast laser micromachining of bioresorbable polymers for fabrication of medical implants and surface modification. In this paper we show that surface structuring of poly(L-lactide) with 300 fs laser pulses at 515 and 1030 nm wavelength leads to formation of defects inside the polymer as a result of laser beam filamentation. Filament-induced channels have diameter around 1 μm and length of hundreds of micrometers. SEM images of microchannels cross-sections are presented. The influence of wavelength and pulse spacing on bulk modification extent was investigated and parameters limiting filamentation were determined. We show that filamentation can be used for controlling properties of PLLA. The presence of filament-induced modifications such as empty microchannels and pressure wave-induced stress lead to increased ability of polymer to crystallize at lower temperature. Crystallization behaviour and crystal morphology after laser treatment was investigated in details using different analytical techniques such as WAXD, DSC and FTIR/ATR. Hydrolytic degradation experiment was performed. Presented method can be applied for controllable, spatially distributed modification of polymer crystallinity, crystalline phase structure and hydrolytic degradation profile.

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“…Though a majority of cell‐adhesion studies have been conducted using stiff biomaterial surfaces, the principle of laser‐based structuring can also be extended to softer hydrogel interfaces or ECM protein‐coated substrates to interrogate cell adhesion and interactions . Laser‐based erosion or structuring has also been extended toward formation of linear or patterned features on hydrogel surfaces to guide cellular alignment, morphogenesis, and differentiation (Figure C) . The ability to selectively modulate these features in 3D scaffolds allows for the study of dynamic cellular behavior in response to user‐defined matrix microarchitectural features and potentially opens new avenues of research in cell–material interactions.…”

Section: Part 2: Applications Of Laser‐based Hydrogel Degradation In mentioning

confidence: 99%

Fundamentals of Laser‐Based Hydrogel Degradation and Applications in Cell and Tissue Engineering

Pradhan

Keller

Sperduto

et al. 2017

Adv Healthcare Materials

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The cell and tissue engineering fields have profited immensely through the implementation of highly-structured biomaterials. The development and implementation of advanced biofabrication techniques has established new avenues for generating biomimetic scaffolds for a multitude of cell and tissue engineering applications. Among these, laser-based degradation of biomaterials has been implemented to achieve user-directed features and functionalities within biomimetic scaffolds. This review offers an overview of the physical mechanisms that govern laser-material interactions and specifically, laser-hydrogel interactions. The influence of both laser and material properties on efficient, high-resolution hydrogel degradation are discussed and the current application space in cell and tissue engineering is reviewed. This review aims to acquaint readers with the capability and uses of laser-based degradation of biomaterials, so that it may be easily and widely adopted.

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FS laser processing of bio-polymer thin films for studying cell-to-substrate specific response

Cited by 19 publications

References 45 publications

Recent advance in surface modification for regulating cell adhesion and behaviors

Recent advance in surface modification for regulating cell adhesion and behaviors

Diverse nature of femtosecond laser ablation of poly(L-lactide) and the influence of filamentation on the polymer crystallization behaviour

Fundamentals of Laser‐Based Hydrogel Degradation and Applications in Cell and Tissue Engineering

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