FSH Beyond Fertility

Lizneva, Daria; Rahimova, Alina; Kim, Semin; Atabiekov, Ihor; Javaid, Seher; Alamoush, Bateel; Taneja, Charit; Khan, Ayesha; Sun, Li; Azziz, Ricardo; Yuen, Tony; Zaidi, Mone

doi:10.3389/fendo.2019.00136

Cited by 59 publications

(36 citation statements)

References 148 publications

(183 reference statements)

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“…No serious adverse events were ever reported as a consequence of FSH replacement treatment in males, and FSH‐producing tumors have no other effects than increasing testis size. Extragonadal effects of FSH are a very much debated issue and, for the time being, should not be a concern. The experimental evidence in humans demonstrates that FSH has no direct role in bone turnover or other metabolic functions …”

Section: Is Pharmacological Testicular Hyperstimulation Expected To Bmentioning

confidence: 99%

FSH treatment of male idiopathic infertility: Time for a paradigm change

Simoni

Santi

2020

Andrology

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Follicle-stimulating hormone (FSH) has been used in inconclusive clinical trials for male idiopathic infertility in the past. FSH is sometimes prescribed empirically for male idiopathic infertility, showing some improvement in sperm parameters in about half of the patients. In this opinion article, we briefly analyze the pathophysiological evidences in favor of a more aggressive approach in planning future studies on pharmacological FSH use in male infertility, in analogy with the FSH use for multiple follicular growth in women undergoing ovarian stimulation for assisted reproduction. There is sufficient evidence that spermatogenesis does not run at its top in the primate and that some extra FSH can stimulate spermatogenesis over its baseline.Existing data suggest that the pharmacological regimens applied so far were insufficient, both in dosage and in duration, to elicit this response in about half of the patients. A paradigm change is needed now: We should move away from the classical, endocrinological approach, which simply applied the substitutive, therapeutic regimen used in hypogonadotropic hypogonadism, toward testing a 'testicular hyperstimulation' scheme for a time sufficient to cover more than only one spermatogenic cycle, a concept to be verified in an appropriately controlled, prospective, randomized clinical trial. K E Y W O R D SFSH, follicle-stimulating hormone, male infertility

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Section: Is Pharmacological Testicular Hyperstimulation Expected To Bmentioning

confidence: 99%

FSH treatment of male idiopathic infertility: Time for a paradigm change

Simoni

Santi

2020

Andrology

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“…Growing evidence supports an estrogen-independent, direct effect of follicular stimulating hormone (FSH) on extragonadal tissue, particularly bone and fat [ 171 , 172 , 173 , 174 ]. Although this matter remains intensively discussed [ 175 , 176 , 177 , 178 , 179 ], osteoclasts and their precursor cells have been shown to express FSH receptors, allowing FSH to directly stimulate osteoclast formation, function and survival [ 173 , 174 ].…”

Section: Molecular Bases Of Brain-bone Crosstalkmentioning

confidence: 99%

Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases

Otto

Knapstein

Jahn

et al. 2020

IJMS

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As brain and bone disorders represent major health issues worldwide, substantial clinical investigations demonstrated a bidirectional crosstalk on several levels, mechanistically linking both apparently unrelated organs. While multiple stress, mood and neurodegenerative brain disorders are associated with osteoporosis, rare genetic skeletal diseases display impaired brain development and function. Along with brain and bone pathologies, particularly trauma events highlight the strong interaction of both organs. This review summarizes clinical and experimental observations reported for the crosstalk of brain and bone, followed by a detailed overview of their molecular bases. While brain-derived molecules affecting bone include central regulators, transmitters of the sympathetic, parasympathetic and sensory nervous system, bone-derived mediators altering brain function are released from bone cells and the bone marrow. Although the main pathways of the brain-bone crosstalk remain ‘efferent’, signaling from brain to bone, this review emphasizes the emergence of bone as a crucial ‘afferent’ regulator of cerebral development, function and pathophysiology. Therefore, unraveling the physiological and pathological bases of brain-bone interactions revealed promising pharmacologic targets and novel treatment strategies promoting concurrent brain and bone recovery.

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“…LH receptors, for instance, in addition to their presence in ovaries and testes, are found in the skin, breast, adrenals, retina, and of course the brain (Ascoli et al 2002). Similarly, the other gonadotropin, follicle-stimulating hormone (FSH), has receptors not only in ovaries and testes, but also in the endothelium, monocytes, bone, and fat (Lizneva et al 2019).…”

Section: The Brain-gonad-longevity Connectionmentioning

confidence: 99%

Sex differences in health and aging: a dialog between the brain and gonad?

Austad

2019

GeroScience

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Women live longer than men in virtually all circumstances. However, a more common pattern among animals is that one sex lives longer under some conditions, the other lives longer under other conditions. In laboratory mice, interventions that extend longevity are surprisingly often sex-specific in their effects. Understanding these conditional sex differences could provide mechanistic insight into how longevity could be modulated in humans. One way that longevity can be consistently enhanced is by inhibiting reproduction or eliminating the capacity to reproduce. Thus, there appears to be a mechanistic link between gonadal activity and longevity. There also appears to be a mechanistic link between some types of neuroendocrine signaling and longevity. Combining these two observations suggest that communication between the brain and gonad is a ripe avenue for further exploring longevity-assurance mechanisms. Also, because the timing and activity of specific brain-gonad endocrine differs between the sexes, neuroendocrine linkages between the brain and gonad, particularly among the less obvious hormones such as activin and inhibin, could provide additional insight into mechanisms of sex differences in aging.

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FSH Beyond Fertility

Cited by 59 publications

References 148 publications

FSH treatment of male idiopathic infertility: Time for a paradigm change

FSH treatment of male idiopathic infertility: Time for a paradigm change

Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases

Sex differences in health and aging: a dialog between the brain and gonad?

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