FT-IR microimaging spectroscopy: A comparison between healthy and neoplastic human colon tissues

FT-IR Spectroscopy Study in Early Diagnosis of Skin Cancer

“…The formed products are similar to those that were also produced upon irradiation of polysaccharides or by using cupric ions (Cu 2+ ) and ascorbic acid (27)(28)(29). The glycosylation has also been shown in other cancers, such as breast and metastatic bone cancers (12,22,30). Furthermore, HA and its CD44 cellular receptors, and the receptor for HA-mediated motility/intracellular HA-binding protein have also been linked to cancer progression and metastasis (31)(32)(33)(34).…”

“…As it is shown in Figure 1, this band increased in intensity in the spectra of BCC, MM, and NEV, indicating that there was substantial reduction in the amount of hydrogen-bonded C-OH groups of cellular proteins, as well as an accumulation of carbohydrates as a result of glycosylation during the cancer progression. This band was also observed in the cancer regions of breast and colon, and metastatic bone cancers (10,12,22). Figure 2 shows the FT-IR spectra of normal healthy tissue (N), basal call carcinoma (BCC), melanoma (MM) and nevus (NEV) specimens.…”

FT-IR Spectroscopy in Medicine

“…Acquired spectra of cells/ tissues give a detailed biochemical fingerprint that varies dependent on the clinical status. It has been successfully applied in the study of various human tissues such as mineralized tissue (Kolovou and Anastasopoulou, 2007), skin (McIntosh, 1999), colon (Conti et al, 2008), breast (Anastassopoulou et al, 2009), arteries (Mamarelis et al, 2010), cartilage (Petra et al, 2005), the urinary tract (prostate, bladder) (Gazi etal., 2003), lung (Yano et al, 2000), liver (Li et al, 2004), heart and spleen (Chua-anusorn and Webb, 2000;Gough et al, 2003).…”

Introduction to Infrared Spectroscopy in Life and Biomedical Sciences

“…Furthermore, with the addition of micro-FT-IR spectrometers one can obtain IR spectra of tissue cells, blood samples, bones and cancerous breast tissues [4][5][6][7]. Samples in solution can also be measured accurately.…”

“…Therefore, IR has also a forensic purpose and is used to analyze substances, such as, alcohol, drugs, fibers, hair, blood and paints [8][9][10][11][12].In the sections that are given in the book the reader will find numerous examples of such applications. …”