FTO genotype, dietary protein intake, and body weight in a multiethnic population of young adults: a cross-sectional study

Merritt, David; Jamnik, Joseph; El‐Sohemy, Ahmed

doi:10.1186/s12263-018-0593-7

Cited by 50 publications

(42 citation statements)

References 52 publications

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“…Previous studies often focused on the effect of interaction of different dietary macronutrients with FTO polymorphisms in relation to obesity (33,34) . Dietary protein intake attenuated the effect of FTO risk variant rs1558902 in relation to BMI or WC (35) ; however, a meta-analysis found no interaction between FTO SNP rs9939609 and dietary protein, carbohydrate, fat or energy intake in relation to BMI (36) . Higher intake of dietary fibre attenuated the association of FTO SNP with general obesity particularly in subjects with high GRS (37) .…”

Section: Discussionmentioning

confidence: 86%

Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes

et al. 2019

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The present study investigated whether dietary patterns could interact with fat mass and obesity-associated (FTO) polymorphisms in relation to changes in BMI and waist circumference (WC) over 3⋅6 years of follow-up. Subjects were selected from participants of the Tehran Lipid and Glucose Study (n 4292, 43⋅2 % male). Dietary data were collected using a valid and reliable FFQ. Dietary patterns were determined using factor analysis. The genotypes of polymorphisms (rs1421085, rs1121980, rs17817449, rs8050136, rs9939973 and rs3751812) were determined. Genetic risk score (GRS) was calculated using the weighted method. Mean ages of men and women were 42·6 (sd 14) and 40⋅4 (sd 13) years, respectively. The healthy (e.g. vegetables and fruits) and the Western dietary patterns (WDP; e.g. soft drinks and fast foods) were extracted. In carriers of the risk alleles rs1121980, rs1421085, rs8050136, rs1781799 and rs3751812, BMI was approximately 2-fold higher in individuals in the higher quartile of WDP score, compared with the first quartile (P < 0⋅05). WC increased with increasing WDP score in carriers of the risk alleles rs1121980 and rs3751812, but not in individuals who did not carry any risk alleles. BMI and WC increased to a greater extent in the high GRS group while increasing quartiles of the WDP score, compared with the low GRS group (BMI change; Q1: 1⋅04 (se 0⋅34) v. Q4: 2⋅26 (se 0⋅36)) (WC change; Q1: 0⋅47 (se 0⋅32) v. Q4: 0⋅95 (se 0⋅34)) (P interaction < 0⋅05). These results suggest that adults with higher genetic predisposition to obesity are more susceptible to the harmful effects of adherence to the WDP, which emphasised the need to reduce the consumption of unhealthy foods for the prevention of obesity.

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Section: Discussionmentioning

confidence: 86%

Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes

et al. 2019

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“…Over the past few decades, public awareness in the field of nutrition and physical activity has increased, but obesity and its comorbidities are still serious international health problems [ 26 ]. It is widely known that the FTO gene is an established genetic susceptibility locus for the risk of obesity development [ 27 ]. However, the association between the FTO gene and dietary factors is still unclear and there is a scientific need to investigate the associations between environmental and genetic risk factors and their interactions and roles in obesity development and treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, we demonstrated an interplay between FTO genetic variants and dietary carbohydrate, protein, and fat intake, and the impact of these interactions on body weight, body fat content and distribution, and other anthropometric measures, as well as on glucose homeostasis and lipid profile, in a Polish population of adults. For our study, we chose some of the most common SNPs based on previously published results [ 25 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of FTO Genetic Variants on Obesity and Its Metabolic Consequences is Dependent on Daily Macronutrient Intake

et al. 2020

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Numerous studies have identified the various fat mass and obesity-associated (FTO) genetic variants associated with obesity and its metabolic consequences; however, the impact of dietary factors on these associations remains unclear. The aim of this study was to evaluate the association between FTO single nucleotide polymorphisms (SNPs), daily macronutrient intake, and obesity and its metabolic consequences. From 1549 Caucasian subjects of Polish origin, genotyped for the FTO SNPs (rs3751812, rs8044769, rs8050136, and rs9939609), 819 subjects were selected for gene–diet interaction analysis. Anthropometric measurements were performed and total body fat content and distribution, blood glucose and insulin concentration during oral glucose tolerance test (OGTT), and lipid profile were determined. Macronutrient intake was analyzed based on three-day food records, and daily physical activity levels were evaluated using the International Physical Activity Questionnaire Long Form (IPAQ-LF). Our study shows that carriers of the GG genotype of rs3751812 presented lower body weight, body mass index (BMI), total body fat content, and hip and waist circumference and presented lower obesity-related markers if more than 48% of daily energy intake was derived from carbohydrates and lower subcutaneous and visceral fat content when energy intake derived from dietary fat did not exceed 30%. Similar results were observed for rs8050136 CC genotype carriers. We did not notice any significant differences in obesity markers between genotypes of rs8044769, but we did observe a significant impact of diet-gene associations. Body weight and BMI were significantly higher in TT and CT genotype carriers if daily energy intake derived from carbohydrates was less than 48%. Moreover, in TT genotype carriers, we observed higher blood glucose concentration while fasting and during the OGTT test if more than 18% of total energy intake was derived from proteins. In conclusion, our results indicate that daily macronutrient intake may modulate the impact of FTO genetic SNPs on obesity and obesity-related metabolic consequences.

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“…FTO might play a role in controlling feeding behavior, modifying energy expenditure (Fawcett & Barroso, 2010), reducing satiety responsiveness (Wardle et al, 2008), increasing consumption of highly palatable food (Wardle et al, 2009), and losing control over eating (Tanofsky-Kraff et al, 2009). Another study suggested a link between FTO, protein intake, and body weight (Merritt, Jamnik & El-Sohemy, 2018). All of these might influence the different effects of FTO on female vs. male, and urban vs. rural.…”

Section: Discussionmentioning

confidence: 99%

Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms

Priliani

Oktavianthi

Hasnita

et al. 2020

PeerJ

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Obesity prevalence is increasing worldwide, including in the Bali Province, Indonesia, a popular tourism destination area. The common single nucleotide polymorphisms (SNPs) rs9939609 and rs1421085 of the fat mass and obesity-associated (FTO) gene have been repeatedly reported as one of the important obesity genetic risk factors. We have examined the associations of FTO rs9939609 and rs1421085 SNPs with obesity in the 612 unrelated Balinese subjects living in urban and rural areas. Linear and logistic regression analyses with adjustment for age and gender were employed to investigate the association between FTO genotypes, haplotypes and obesity parameters. We found that the FTO SNPs genotypes increased BMI by 1.25 kg/m2 (p = 0.012) for rs9939609 AA and 1.12 kg/m2 (p = 0.022) for rs1421085 CC, particularly in females and in rural population. Subjects carrying these genotypes also showed a tendency to maintain high BMI, regardless of their age. Our result showed that the FTO rs9939609 and rs1421085 risk alleles were associated with increased BMI and obesity in the Balinese.

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FTO genotype, dietary protein intake, and body weight in a multiethnic population of young adults: a cross-sectional study

Cited by 50 publications

References 52 publications

Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes

Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes

The Impact of FTO Genetic Variants on Obesity and Its Metabolic Consequences is Dependent on Daily Macronutrient Intake

Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms

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