FTRIFS biosensor based on double layer porous silicon as a LC detector for target molecule screening from complex samples

Surface Functionality Features of Porous Silicon Prepared and Treated in Different Conditions

“…Biomedical applications of por-Si involve the use as a carrier for target delivery of single or combined drugs [5][6][7][8][9], photosensitive agents in photodynamic therapy and in tissue engineering [10], various biodetectors, and biomedical imaging [11] including tumor visualization, as well as eye diseases. Modified por-Si layers can be used in biosensors [1,2,4,[12][13][14][15][16][17] for various applications including the determination of glucose, DNA, antibodies, bacteria, and viruses [12][13][14]. This application area involves different types of sensors, including electric, electrochemical, optical, and labeling devices [15][16][17].…”

“…Modified por-Si layers can be used in biosensors [1,2,4,[12][13][14][15][16][17] for various applications including the determination of glucose, DNA, antibodies, bacteria, and viruses [12][13][14]. This application area involves different types of sensors, including electric, electrochemical, optical, and labeling devices [15][16][17]. Biosensor application of por-Si also includes the use in passive platforms for the deposition of biological cultures and active elements interaction with the biological environment [15,18,19].…”

Direct Optical Detection in Bioanalytics

“…Another interesting approach is a Fourier transform version used as LC detector [209] for characterizing antibodies with respect to their affinity constants in affinity chromatography [210]. To qualify the surface modification, affinity constants of LNA (locked nucleic acid) and DNA duplex formation were determined [211] and endocrine receptors were examined [212];cell morphology also can be examined by RIfS [213].…”

Nitrogen- and Sulfur-Codoped Carbon Dots for Highly Selective and Sensitive Fluorescent Detection of Hg2+ Ions and Sulfide in Environmental Water Samples

“…Rapid and sensitive detection of chemical contaminants in environmental samples is significant and challenging. Recently, many analytical techniques for environmental analysis, such as the use of fluorescent sensors, have been developed with nanomaterials. − Fluorescent (FL) carbon dots (CDs), a fascinating kind of carbon nanomaterial, have attracted great attention because of their prominent optical properties, good biocompatibility, low cost, low toxicity, and chemical inertness. − Several methods have been elaborated for the preparation of fluorescent CDs, such as hydrothermal-cutting strategies, chemical-oxidation methods, microwave-assisted methods, carbonizing-organics routes, and electrochemical-oxidation processes. In order to improve the FL properties of CDs, CDs are doped.…”