FtsH is required for protein secretion homeostasis and full bacterial virulence in Edwardsiella piscicida

Wang, Wei; Jiang, Jiatiao; Chen, Hao; Zhang, Yuanxing; Liu, Qin

doi:10.1016/j.micpath.2021.105194

Cited by 2 publications

(1 citation statement)

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“…细胞周质(Periplasm)是革兰氏阴性细菌位于内膜和外膜之间的结构部分, 在感应外界信号、抵御不利环境、维持细胞结构和功能等方面发挥着重要作用, 还控制着决定细菌运动性的鞭毛形成和毒力因子的功能发挥等 [24~26] . 在杀鱼爱德华氏菌中, 已发现质膜双组份系统 CpxRA [27] 、内膜蛋白 YccA [28] 、周质蛋白酶 DegP [29] 和质膜蛋白酶 FtsH [30] 等与细菌抗逆与毒力密切相关. 质膜蛋白酶有助于膜蛋白的质量控制 [31] , 可以清除干扰细菌细胞膜结构和功能的畸形和/或错误组装的膜蛋白, 这对正常细胞活动至关重要 [32] .…”

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The pathogenicity and regulation of the plasma membrane protease HtpX in <italic>Edwardsiella piscicida</italic>

WU,

XU,

FANG

et al. 2024

Sci. Sin.-Vitae

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The pathogenicity and regulation of the plasma membrane protease HtpX in <italic>Edwardsiella piscicida</italic>

WU,

XU,

FANG

et al. 2024

Sci. Sin.-Vitae

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Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis

et al. 2023

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Infection with the main human food-borne pathogen Campylobacter jejuni causes campylobacteriosis that accounts for a substantial percentage of gastrointestinal infections. The disease usually manifests as diarrhea that lasts for up to two weeks. C. jejuni possesses an array of peptidases and proteases that are critical for its lifestyle and pathogenesis. These include serine proteases Cj1365c, Cj0511 and HtrA; AAA+ group proteases ClpP, Lon and FtsH; and zinc-dependent protease PqqE, proline aminopeptidase PepP, oligopeptidase PepF and peptidase C26. Here, we review the numerous critical roles of these peptide bond-dissolving enzymes in cellular processes of C. jejuni that include protein quality control; protein transport across the inner and outer membranes into the periplasm, cell surface or extracellular space; acquisition of amino acids and biofilm formation and dispersal. In addition, we highlight their role as virulence factors that inflict intestinal tissue damage by promoting cell invasion and mediating cleavage of crucial host cell factors such as epithelial cell junction proteins. Furthermore, we reconstruct the evolution of these proteases in 34 species of the Campylobacter genus. Finally, we discuss to what extent C. jejuni proteases have initiated the search for inhibitor compounds as prospective novel anti-bacterial therapies.

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FtsH is required for protein secretion homeostasis and full bacterial virulence in Edwardsiella piscicida

Cited by 2 publications

References 38 publications

The pathogenicity and regulation of the plasma membrane protease HtpX in <italic>Edwardsiella piscicida</italic>

The pathogenicity and regulation of the plasma membrane protease HtpX in <italic>Edwardsiella piscicida</italic>

Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis

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FtsH is required for protein secretion homeostasis and full bacterial virulence in Edwardsiella piscicida

Cited by 2 publications

References 38 publications

The pathogenicity and regulation of the plasma membrane protease HtpX in &lt;italic&gt;Edwardsiella piscicida&lt;/italic&gt;

The pathogenicity and regulation of the plasma membrane protease HtpX in &lt;italic&gt;Edwardsiella piscicida&lt;/italic&gt;

Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis

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The pathogenicity and regulation of the plasma membrane protease HtpX in <italic>Edwardsiella piscicida</italic>

The pathogenicity and regulation of the plasma membrane protease HtpX in <italic>Edwardsiella piscicida</italic>