Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoEshl mice deficient in apolipoprotein E expression

Yokota, Takashi; Nomura, Koichi; Nagashima, Masakazu; Kamimura, Naomi

doi:10.1016/j.jnutbio.2016.01.011

Cited by 99 publications

(95 citation statements)

References 46 publications

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“…Due to fucoidan's additional effect on dyslipidemia, the liver has been identified as a possible target with research focusing on hepatic lipid metabolism. Peroxisome proliferator-activated receptor alpha (PPARα), which regulates hepatic fatty acid β-oxidation and is decreased in high fat diets, had significantly upregulated gene expression in the Apo shl study described previously ( 11 ). Sterol regulatory element-binding protein 1 (SREBP1) regulates expression of lipogenic genes acetyl-CoA-carboxylase (ACC) and fatty acid synthetase (FAS).…”

Section: Fucoidanmentioning

confidence: 81%

“…A study in which low density lipoprotein receptor null (LDLR −/− ) mice were fed a high cholesterol diet and treated with 100 mg/kg fucoidan through intragastric gavage, found that atherosclerotic plaques were significantly reduced in the aortic arch, descending thoracic aorta and abdominal aorta ( 10 ). In another study, spontaneously hyperlipidemic (Apo shl ) mice were fed a high fat diet with fucoidan consisting of 1% and 5% of their daily food intake ( 11 ). After 12 weeks, the atherosclerotic lesion area of their aortas was significantly lower in the mice treated with fucoidan (Figures 4A,B ) ( 11 ).…”

Section: Fucoidanmentioning

confidence: 99%

“…In another study, spontaneously hyperlipidemic (Apo shl ) mice were fed a high fat diet with fucoidan consisting of 1% and 5% of their daily food intake ( 11 ). After 12 weeks, the atherosclerotic lesion area of their aortas was significantly lower in the mice treated with fucoidan (Figures 4A,B ) ( 11 ). These results were also supported by a study in which poloxamer-407 (P-407) was used to induce atherosclerotic lesions and hyperlipidemia in mice through lipid derangement ( 12 , 13 ).…”

Section: Fucoidanmentioning

confidence: 99%

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Algal Polysaccharides as Therapeutic Agents for Atherosclerosis

Patil

Sligar

et al. 2018

Front. Cardiovasc. Med.

100

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Seaweed-derived polysaccharides including agar and alginate, have found widespread applications in biomedical research and medical therapeutic applications including wound healing, drug delivery, and tissue engineering. Given the recent increases in the incidence of diabetes, obesity and hyperlipidemia, there is a pressing need for low cost therapeutics that can economically and effectively slow the progression of atherosclerosis. Marine polysaccharides have been consumed by humans for millennia and are available in large quantities at low cost. Polysaccharides such as fucoidan, laminarin sulfate and ulvan have shown promise in reducing atherosclerosis and its accompanying risk factors in animal models. However, others have been tested in very limited context in scientific studies. In this review, we explore the current state of knowledge for these promising therapeutics and discuss the potential and challenges of using seaweed derived polysaccharides as therapies for atherosclerosis.

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Section: Fucoidanmentioning

confidence: 81%

Section: Fucoidanmentioning

confidence: 99%

Section: Fucoidanmentioning

confidence: 99%

See 1 more Smart Citation

Algal Polysaccharides as Therapeutic Agents for Atherosclerosis

Patil

Sligar

et al. 2018

Front. Cardiovasc. Med.

100

View full text Add to dashboard Cite

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“…A recent study also found that fucoidan from Laminaria japonica can improve the atherosclerotic cardiovascular disease by reducing the production of ROS by inhibiting NADPH oxidase subunit 4 ( Figure 2) [74]. Another study showed that fucoidan derived from Cladosiphon okamuranus Tokida significantly inhibits LDL-C peroxidation and hepatic steatosis in the apolipoprotein E-deficient mice by activating plasma lipoprotein lipase activity, thus alleviating the dyslipidemia and atherosclerosis in the mice (Figure 2) [71]. These studies indicate that fucoidan inhibits the generation of ROS in vivo and then relieves the oxidative damage in a variety of pathways.…”

Section: Brown Algal Polysaccharidesmentioning

confidence: 94%

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

et al. 2019

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Marine-derived antioxidant polysaccharides have aroused extensive attention because of their potential nutritional and therapeutic benefits. However, the comprehensive comparison of identified marine-derived antioxidant polysaccharides is still inaccessible, which would facilitate the discovery of more efficient antioxidants from marine organisms. Thus, this review summarizes the sources, chemical composition, structural characteristics, and antioxidant capacity of marine antioxidant polysaccharides, as well as their protective in vivo effects mediated by antioxidative stress reported in the last few years (2013–2019), and especially highlights the dominant role of marine algae as antioxidant polysaccharide source. In addition, the relationships between the chemical composition and structural characteristics of marine antioxidant polysaccharides with their antioxidant capacity were also discussed. The antioxidant activity was found to be determined by multiple factors, including molecular weight, monosaccharide composition, sulfate position and its degree.

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“…Seaweed has gained increasing interest for its potential role in cardiovascular disease (CVD) prevention 1,2) . Seaweed contains dietary fibers, peptides, and carotenoids that have beneficial effects on cardiovascular risk factors including blood pressure [3][4][5][6][7] , serum lipids [8][9][10] , and fatty acid 11) , blood glucose 12) , and body weight 9,13,14) . However, the health effect due to the the frequency scores and estimated nutrients for each portion and summing across all 33 items.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Seaweed Intake and Its Association with Cardiovascular Disease Mortality: The JACC Study

Kishida

Yamagishi

Muraki

et al. 2020

JAT

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Seaweed is a popular traditional foodstuff in Asian countries. To our knowledge, few studies have examined the association of seaweed intake with mortality from cardiovascular disease. We examined the association of frequency of seaweed intake with total and specific cardiovascular disease mortality. Methods: We examined the association of seaweed intake with mortality from cardiovascular disease among 40,234 men and 55,981 women who participated in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Sex-specific hazard ratios for mortality from cardiovascular disease (stroke, stroke subtypes, and coronary heart disease) according to the frequency of seaweed intake were calculated stratified by study area and adjusted for potential cardiovascular risk factors and dietary factors. Results: During the 1,580,996 person-year follow-up, 6,525 cardiovascular deaths occurred, of which 2,820 were due to stroke, and 1,378, to coronary heart disease. Among men, the multivariable analysis showed that participants who ate seaweed almost every day compared with those who never ate seaweed had hazard ratios (95% confidence interval; P for trend) of 0.79 (0.62-1.01; 0.72) for total cardiovascular disease, 0.70 (0.49-0.99; 0.47) for total stroke, 0.69 (0.41-1.16; 0.11) for cerebral infarction. Among women, the multivariable-adjusted hazard ratios were 0.72 (0.55-0.95; 0.001) for total cardiovascular disease, 0.70 (0.46-1.06; 0.01) for total stroke, and 0.49 (0.27-0.90; 0.22) for cerebral infarction. No associations were observed between seaweed intake and risk of intraparenchymal hemorrhage and coronary heart disease among either men or women. Conclusions: We found an inverse association between seaweed intake and cardiovascular mortality among Japanese men and women, especially that from cerebral infarction. combination of these nutrients and other nutrients as food is largely known. Seaweed is a popular traditional foodstuff in Asian countries, including Japan, Korea, and parts of China. For example, on average, Japanese population consumes 9.9 g of seaweed a day 15). Japan's longest life expectancy and the lowest CVD mortality in the world 16) could be due to their unique dietary patterns 17) , which are partly characterized by regular Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoEshl mice deficient in apolipoprotein E expression

Cited by 99 publications

References 46 publications

Algal Polysaccharides as Therapeutic Agents for Atherosclerosis

Algal Polysaccharides as Therapeutic Agents for Atherosclerosis

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

Frequency of Seaweed Intake and Its Association with Cardiovascular Disease Mortality: The JACC Study

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