Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Abstract

Background Radioiodine (RI) treatments can destroy the cellular components of salivary glands (SG) and disrupt their function. This study investigated whether fucoidan could attenuate radioiodine-induced SG dysfunction in a mouse model. Methods Female C57BL/6 mice ( n = 36) were classified into three groups; i) a normal (control) group, ii) an RI-treated group (0.2 mCi/20 g mouse, administered orally), and iii) a fucoidan and RI-treated group. Mice in each group were classified into three subgroups and sacrificed at 2, 4, and 12 weeks after RI treatment. The measurements of salivary flow rates and lag times and histomorphologic examinations were performed, and apoptotic assays were conducted. Changes in salivary 99m Technetium (Tc)-pertechnetate parameters using single-photon emission computed tomography were followed. Results Salivary flow rates and lag times in the fucoidan group were improved compared to the RI-treated group. Histologic examinations of SGs in the fucoidan group showed mucin-rich parenchymal areas and reduced periductal fibrosis as compared to the RI-treated group. Moreover, compared with the RI-treated group, fucoidan-treated groups showed evidence of cytoprotection, with a greater number of salivary epithelial cells and myoepithelial cells being observed. Fewer apoptotic cells were observed in the fucoidan group as compared to the RI group. The extent of 99m Tc pertechnetate excretion in the fucoidan group was similar to that of the control group. Conclusion Our results demonstrate that fucoidan administration before RI treatment could attenuate RI-induced SG damage and provides a possible candidate for preventing SG damage induced by RI.

Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis

“…Fucoidan exerts several therapeutic effects, including immunomodulatory [ 30 , 31 ], anti-cancer [ 54 ], and anti-fibrosis [ 36 , 55 ]. Because OSF is regarded as a precancerous disorder, the effect of fucoidan on the tissue fibrosis caused by cancer therapy caught our attention.…”

“…Because OSF is regarded as a precancerous disorder, the effect of fucoidan on the tissue fibrosis caused by cancer therapy caught our attention. Fucoidan ameliorated radiation-induced lung fibrosis by decreasing inflammatory cytokine expression [ 36 ], and attenuated radioiodine-induced salivary gland injury and fibrosis [ 55 ]. To our knowledge, the therapeutic effects of fucoidan on oral fibrosis remain unclear.…”

Therapeutic potential of fucoidan in dentistry: A review

“…Salivary gland histology showed areas of mucin-rich parenchyma and decreased periductal fibrosis. Fucoidan therapy also resulted in increased myoepithelial and salivary epithelial cells as well as decreased apoptotic cells (63).…”

Targeting FOS attenuates malignant phenotypes of breast cancer: Evidence from in silico and in vitro studies

“…[ 5,6 ] Bioinformatics research for finding biological mechanisms in BC can be done by analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data‐based interpretation. [ 7,8 ] In this context, it is important to seek novel targets for control of the progression of BC through bioinformatics studies.…”