Fucoidan coated ciprofloxacin loaded chitosan nanoparticles for the treatment of intracellular and biofilm infections of Salmonella

Elbi, S; Nimal, T. R.; Rajan, Vijisha K.; Baranwal, Gaurav; Biswas, Raja; Jayakumar, R.; Sathianarayanan, S.

doi:10.1016/j.colsurfb.2017.09.003

Cited by 77 publications

(9 citation statements)

References 38 publications

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“…In addition, fucoidan can synergistically enhance the efficacy of anti-inflammatory drugs. Fucoidan-coated ciprofloxacin-loaded chitosan nanoparticles can effectively treat intracellular and biofilm infections of Salmonella [112]. Compared to other small molecule anti-inflammatory drugs, fucoidan as a macromolecular substance has broad prospects as a direct drug or food adjuvant.…”

Section: Classical Activities Of Fucoidanmentioning

confidence: 99%

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

et al. 2019

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The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique biological structure. Classical activities include antitumor, antioxidant, anticoagulant, antithrombotic, immunoregulatory, antiviral and anti-inflammatory effects. More recently, fucoidan has been shown to alleviate metabolic syndrome, protect the gastrointestinal tract, benefit angiogenesis and bone health. This review focuses on the progress in our understanding of the biological activities of fucoidan, highlighting its benefits for the treatment of human disease. We hope that this review can provide some theoretical basis and inspiration for the product development of fucoidan.

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Section: Classical Activities Of Fucoidanmentioning

confidence: 99%

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

et al. 2019

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“…Other methods are coacervation, ionic cross-linking, self-assembly, and spray-drying [2]. Fucoidan-based particles served as carriers of various substances, including drugs (ciprofloxacin [40], gentamicin [41], doxorubicin [42], isoniazid and rifabutin [43]), growth factors (basic fibroblast growth factor—bFGF [44], proteins (bovine serum albumin [45], β-lactoglobulin [46]), and genes [47]. Interestingly, fucoidan is used not only as an excipient responsible for drug delivery, but also as a proper substance with therapeutic effects [12,48].…”

Section: Fucoidan Application In the Pharmaceutical Technologymentioning

confidence: 99%

“…Due to its ability to muco-adhesion and overcoming epithelial barriers, it facilitates the transport of active substances. Importantly, similar to fucoidan, it is biocompatible and its acquisition costs are relatively low [40,56,57]. In 2012, Silva et al compared the activity of fucoidan–chitosan nanoparticles with the effect of fucoidan solution.…”

Section: Fucoidan Application In the Pharmaceutical Technologymentioning

confidence: 99%

Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms

2019

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Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad biological activity, including possible antioxidant, anti-inflammatory, antifungal, antiviral or antithrombotic effects. The potential application of fucoidan in the pharmaceutical technology is also due to its ionic nature. The negative charge of the molecule results from the presence of sulfate residues in the C-2 and C-4 positions, occasionally in C-3, allowing the formation of complexes with other oppositely charged molecules. Fucoidan is non-toxic, biodegradable and biocompatible compound approved by Food and Drug Administration (FDA) as Generally Recognized As Safe (GRAS) category as food ingredient. Fucoidan plays an important role in the pharmaceutical technology, so in this work aspects concerning its pharmaceutical characteristics and designing of various dosage forms (nanoparticles, liposomes, microparticles, and semisolid formulations) with fucoidan itself and with its combinations with other polymers or components that give a positive charge were reviewed. Advantages and limitations of fucoidan utilization in the pharmaceutical technology were also discussed.

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“…A straightforward design involves using antibiotics in nanocarriers. In one example, Elbi et al [54] developed chitosan nanoparticles containing ciprofloxacin and coated with Fucoidan to enhance antimicrobial activity and the endocytosis of the material into macrophages to kill intracellular bacteria. The authors showed that the nanocarriers effectively dispersed the 2 day old S. Paratyphi A biofilm, significantly more effective than ciprofloxacin alone (1.6 times better) and were not toxic to RAW 264.7 macrophages after 48 h of treatment.…”

Section: Nanomaterials As Carriers Of Biofilm-eradicating Agentsmentioning

confidence: 99%

“…The authors showed that the nanocarriers effectively dispersed the 2 day old S. Paratyphi A biofilm, significantly more effective than ciprofloxacin alone (1.6 times better) and were not toxic to RAW 264.7 macrophages after 48 h of treatment. Furthermore, the nanocarriers also entered the macrophages and killed the intracellular S. Paratyphi A in a coculture model [54]. Mu et al [55] utilized a similar concept for P. aeruginosa and S. aureus biofilm treatment.…”

Section: Nanomaterials As Carriers Of Biofilm-eradicating Agentsmentioning

confidence: 99%

Nanomaterials for Treating Bacterial Biofilms on Implantable Medical Devices

Tran

Booth

et al. 2020

Nanomaterials

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Bacterial biofilms are involved in most device-associated infections and remain a challenge for modern medicine. One major approach to addressing this problem is to prevent the formation of biofilms using novel antimicrobial materials, device surface modification or local drug delivery; however, successful preventive measures are still extremely limited. The other approach is concerned with treating biofilms that have already formed on the devices; this approach is the focus of our manuscript. Treating biofilms associated with medical devices has unique challenges due to the biofilm’s extracellular polymer substance (EPS) and the biofilm bacteria’s resistance to most conventional antimicrobial agents. The treatment is further complicated by the fact that the treatment must be suitable for applying on devices surrounded by host tissue in many cases. Nanomaterials have been extensively investigated for preventing biofilm formation on medical devices, yet their applications in treating bacterial biofilm remains to be further investigated due to the fact that treating the biofilm bacteria and destroying the EPS are much more challenging than preventing adhesion of planktonic bacteria or inhibiting their surface colonization. In this highly focused review, we examined only studies that demonstrated successful EPS destruction and biofilm bacteria killing and provided in-depth description of the nanomaterials and the biofilm eradication efficacy, followed by discussion of key issues in this topic and suggestion for future development.

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Fucoidan coated ciprofloxacin loaded chitosan nanoparticles for the treatment of intracellular and biofilm infections of Salmonella

Cited by 77 publications

References 38 publications

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms

Nanomaterials for Treating Bacterial Biofilms on Implantable Medical Devices

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