2013
DOI: 10.3390/md11061961
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Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

Abstract: Fucoidans, fucose-enriched sulfated polysaccharides isolated from brown algae and marine invertebrates, have been shown to exert anticancer activity in several types of human cancer, including leukemia and breast cancer and in lung adenocarcinoma cells. In the present study, the anticancer activity of the fucoidan extracted from the brown seaweed Undaria pinnatifida was investigated in human hepatocellular carcinoma SMMC-7721 cells, and the underlying mechanisms of action were investigated. SMMC-7721 cells exp… Show more

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Cited by 148 publications
(105 citation statements)
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“…ROS inducers as anticancer drugs have received considerable attention due to their selective effect on cancer cells while sparing normal cells (25). Emerging evidence suggests that ROS induced apoptotic cell death in cancer cells by causing mitochondrial membrane damage, resulting in a mitochondrial membrane potential disorder (26)(27)(28). We examined the mitochondrial membrane potential using a JC-1 stain and our results suggest that HF induces ROS generation and affects mitochondrial dynamics, inducing the dysfunction of mitochondrial membrane potential (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…ROS inducers as anticancer drugs have received considerable attention due to their selective effect on cancer cells while sparing normal cells (25). Emerging evidence suggests that ROS induced apoptotic cell death in cancer cells by causing mitochondrial membrane damage, resulting in a mitochondrial membrane potential disorder (26)(27)(28). We examined the mitochondrial membrane potential using a JC-1 stain and our results suggest that HF induces ROS generation and affects mitochondrial dynamics, inducing the dysfunction of mitochondrial membrane potential (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Fucoidan is a fucose-rich polysaccharide present in the extracellular matrix of brown algae and is reported to possess anti-cancer activities in many different types of cancer cells, including leukemia, breast cancer, prostate cancer, lung adenocarcinoma, and hepatocellular carcinoma cells (Boo et al 2013;Park et al 2013;Senthilkumar et al 2013;Yang et al 2013;Zhang et al 2013). Hepatocellular carcinoma cells exposed to fucoidan displayed growth inhibition and apoptosis via the reactive oxygen speciesmediated mitochondrial pathway .…”
Section: Discussionmentioning
confidence: 99%
“…Several biological activities of fucoidan have been reported including, anti-inflammatory, antiviral, anti-coagulant, and anti-angiogenic effects (Zapopozhets et al 1995;Durig et al 1997;Senthilkumar et al 2013;Senthilkumar & Kim 2014). The anti-cancer activities of fucoidan have been demonstrated in many different types of cancers such as breast cancer, adenocarcinoma, and colon cancer by arresting the cell cycle and inducing apoptosis (Boo et al 2013;Park et al 2013;Senthilkumar et al 2013;Yang et al 2013).…”
Section: Introductionmentioning
confidence: 99%
“…Dox treatment increased the activities of caspase-3/8/9 to 7.3, 3.2 and 5.4-fold above control cells, respectively. SPPC-induced apoptosis has been associated with the mitochondrial signaling pathway via activation of caspase-9 (27,28). Co-treatment with Dox and SPPC resulted in markedly higher ratios of caspase-3 and caspase-9 activity, which were 13.1 and 8.9-fold that of controls.…”
Section: Sppc Enhances Dox-induced Caspase Activationmentioning
confidence: 96%