Fucoidan from Fucus vesiculosus can inhibit human norovirus replication by enhancing the host innate immune response

Tan, Malcolm Turk Hsern; Gorji, Mohamad Eshaghi; Toh, Jillinda Yi Ling; Park, Ah Young; Li, Yan; Gong, Zhiyuan; Li, Dan

doi:10.1016/j.jff.2022.105149

Cited by 11 publications

(4 citation statements)

References 46 publications

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“…Edible films/coatings based on polysaccharides, such as Arabic gum [30,146], guar gum [147], chitosan [148], fucoidan [65], pectin [149], and ulvan [150], on some proteins, such as milk protein derivatives/compounds, such as casein hydrolysate and casein phosphopeptides [151,152], and on lipids, such as candelilla wax [153], have revealed antimicrobial properties. In particular, fucoidan and ulvan have been shown to be antibacterial and antiviral [65,154,155]. In addition, when chitosan is used in edible films/coating formulations, it normally decreases the pH of the solution, which prevents microbial growth [118,148].…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

“…For example, whey protein films incorporated with cinnamon essential oil (EO) showed high antibacterial activity against E. coli and S. aureus and an inhibitory effect on fungi [152]. Gelatine films incorporated with casein phosphopeptides showed good inhibition against S. aureus and B. cereus but not against E. coli [155]. Candelilla wax-based films with Flourensia cernua extracts showed antifungal activity against B. cynerea, C. gloeosporioides, and F. oxysporum [153].…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

“…However, some studies have focused on the base compounds of edible films and coatings, as well as the inclusion of bioactive compounds in these formulations. One example is fucoidan, which possesses antibacterial, antiviral, and antioxidant properties (already discussed), and has also been reported to provide health benefits, such as anticancer, immunoregulatory, anti-thrombotic, and anti-inflammatory effects [155]. Although the health properties of fucoidan-based edible coatings have not been specifically tested, they do constitute potential functionalities.…”

Section: Health Effects Of Edible Films and Coatingsmentioning

confidence: 99%

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Recent Highlights in Sustainable Bio-Based Edible Films and Coatings for Fruit and Vegetable Applications

Martins,

Pintado,

Morais

et al. 2024

Foods

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The present review paper focuses on recent developments in edible films and coatings made of base compounds from biological sources, namely plants, animals, algae, and microorganisms. These sources include by-products, residues, and wastes from agro-food industries and sea products that contribute to sustainability concerns. Chitosan, derived from animal biological sources, such as crustacean exoskeletons, has been the most studied base compound over the past three years. Polysaccharides typically constitute no more than 3–5% of the film/coating base solution, with some exceptions, like Arabic gum. Proteins and lipids may be present in higher concentrations, such as zein and beeswax. This review also discusses the enrichment of these bio-based films and coatings with various functional and/or bioactive compounds to confer or enhance their functionalities, such as antimicrobial, antioxidant, and anti-enzymatic properties, as well as physical properties. Whenever possible, a comparative analysis among different formulations was performed. The results of the applications of these edible films and coatings to fruit and vegetable products are also described, including shelf life extension, inhibition of microbial growth, and prevention of oxidation. This review also explores novel types of packaging, such as active and intelligent packaging. The potential health benefits of edible films and coatings, as well as the biodegradability of films, are also discussed. Finally, this review addresses recent innovations in the edible films and coatings industry, including the use of nanotechnologies, aerogels, and probiotics, and provides future perspectives and the challenges that the sector is facing.

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Section: Antimicrobial Propertiesmentioning

confidence: 99%

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Section: Health Effects Of Edible Films and Coatingsmentioning

confidence: 99%

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Recent Highlights in Sustainable Bio-Based Edible Films and Coatings for Fruit and Vegetable Applications

Martins,

Pintado,

Morais

et al. 2024

Foods

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“…The fucoidan extracted from F. vesiculosus enhances the host’s innate immune response and inhibits the replication of human norovirus (hNoV), which causes acute gastroenteritis. The antiviral action of fucoidan demonstrated on hNoV-infected zebrafish larvae is exerted through the up-regulation of the expression of a series of interferon-stimulated genes that encode antiviral effectors, including helz2, marco and rsad2 (viperin) [ 84 ].…”

Section: Biological Action and Health Benefits Of Fucoidanmentioning

confidence: 99%

Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry

Anisha¹,

Padmakumari²,

Patel

et al. 2022

Bioengineering

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The marine macroalgae produce a collection of bioactive polysaccharides, of which the sulfated heteropolysaccharide fucoidan produced by brown algae of the class Phaeophyceae has received worldwide attention because of its particular biological actions that confer nutritional and health benefits to humans and animals. The biological actions of fucoidan are determined by their structure and chemical composition, which are largely influenced by the geographical location, harvest season, extraction process, etc. This review discusses the structure, chemical composition and physicochemical properties of fucoidan. The biological action of fucoidan and its applications for human health, tissue engineering, regenerative medicine and drug delivery are also addressed. The industrial scenario and prospects of research depicted would give an insight into developing fucoidan as a commercially viable and sustainable bioactive material in the nutritional and pharmacological sectors.

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Utilizing Zebrafish Embryos for Replication of Tulane Virus: A Human Norovirus Surrogate

Chandran,

Gibson

2024

Food Environ Virol

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The zebrafish larvae/embryo model has been shown to support the replication of seven strains (G1.7[P7], GII.2[P16], GII.3[P16], GII.4[P4], GII.4[P16], GII.6[P7], and GII.17[P13]) of human norovirus (HuNoV). However, due to challenges in consistently obtaining HuNoV-positive stool samples from clinical sources, evaluating HuNoV surrogates in this model is highly valuable. This study assesses the potential of zebrafish embryos and larvae as a model for Tulane virus (TuV) replication. Three infection methods were examined: microinjection, immersion, and feeding. Droplet digital PCR was used to quantify viral RNA across all three infection methods. Microinjection of 3 nL of TuV into zebrafish embryos (< 6-h post-fertilization) resulted in significant replication, with viral RNA levels reaching 6.22 logs at 4-day post-infection. In contrast, the immersion method showed no replication after immersing 4-day post-fertilization (dpf) larvae in TuV suspension for 6 h. Similarly, no replication was observed with the feeding method, where Paramecium caudatum loaded with TuV were fed to 4 dpf larvae. The findings indicate that the zebrafish embryo model supports TuV replication through the microinjection method, suggesting that TuV may serve as a useful surrogate for studying HuNoV pathogenesis. Additionally, TuV can be utilized in place of HuNoV in method optimization studies using the zebrafish embryo model, circumventing the limited availability of HuNoV.

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Fucoidan from Fucus vesiculosus can inhibit human norovirus replication by enhancing the host innate immune response

Cited by 11 publications

References 46 publications

Recent Highlights in Sustainable Bio-Based Edible Films and Coatings for Fruit and Vegetable Applications

Recent Highlights in Sustainable Bio-Based Edible Films and Coatings for Fruit and Vegetable Applications

Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry

Utilizing Zebrafish Embryos for Replication of Tulane Virus: A Human Norovirus Surrogate

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