Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4

Wang, Yiming; Wang, Jingfeng; Zhao, Yanlei; Hu, Shiwei; Shi, Dai; Xue, Changhu

doi:10.1016/j.jbiosc.2015.05.012

Cited by 51 publications

(36 citation statements)

References 43 publications

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“…; Wang et al. ,b), which supported our initial hypothesis that fucoidan would improve glycemia in obese mice and that MSR1 would mitigate its efficacy. Surprisingly, fucoidan worsened insulin resistance in an MSR1‐dependent manner.…”

Section: Discussionsupporting

confidence: 69%

Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice

Cavallari¹,

Anhê²,

Foley³

et al. 2018

Physiol Rep

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Immune components can bridge inflammatory triggers to metabolic dysfunction. Scavenger receptors sense lipoproteins, but it is not clear how different scavenger receptors alter carbohydrate metabolism during obesity. Macrophage scavenger receptor 1 (MSR1) and macrophage receptor with collagenous structure (MARCO) are scavenger receptors that have been implicated in lipoprotein metabolism and cardiovascular disease. We assessed glucose control, tissue‐specific insulin sensitivity, and inflammation in Msr1‐ and Marco‐deficient mice fed with obesogenic diets. Compared to wild‐type (WT) mice, Msr1 −/− mice had worse blood glucose control that was only revealed after diet‐induced obesity, not in lean mice. Obese Msr1 −/− mice had worse insulin‐stimulated glucose uptake in the adipose tissue, which occurred in the absence of overt differences in adipose inflammation compared to obese WT mice. Msr1 deletion worsened dysglycemia independently from bacterial cell wall insulin sensitizers, such as muramyl dipeptide. MARCO was dispensable for glycemic control in obese mice. Oral administration of the polysaccharide fucoidan worsened glucose control in obese WT mice, but fucoidan had no effect on glycemia in obese Msr1 −/− mice. Therefore, MSR1 is a scavenger receptor responsible for changes in glucose control in response to the environmental ligand fucoidan. Given the interest in dietary supplements and natural products reducing inflammation or insulin resistance in metabolic disease during obesity, our results highlight the importance of understanding which ligand–receptor relationships promote versus those that protect against metabolic disease factors. Our results show that ligand or gene targeting of MSR1 exacerbates insulin resistance in obese mice.

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Section: Discussionsupporting

confidence: 69%

Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice

Cavallari¹,

Anhê²,

Foley³

et al. 2018

Physiol Rep

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“…15,16 Animal studies have shown that fucoidan with low molecular form influences glucose metabolism, including the promotion of insulin secretion, pancreatic protection, improvement of insulin resistance and inhibiting the progression of diabetic nephropathy. [17][18][19][20][21][22][23] However, only a few animal studies using high molecular weight fucoidan were performed so far because of its rather labile nature despite an ample history of use as foods in humans. In fact, high molecular weight fucoidan was reported to increase intestinal peristalsis in humans, 24 whereas its effects on diabetes and glucose metabolism have not been investigated so far.…”

mentioning

confidence: 99%

A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity

Sakai

Abe²,

Kouzuki

et al. 2019

Yonago Acta Med.

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Background Fucoidan is derived from seaweed widely used in Japanese cuisine, but little is known about its influence on glucose metabolism. To obtain information about the physiological effects of fucoidan on glucose metabolism, the digestive system, and the gustatory system controlling taste sensation in patients with type 2 diabetes, we conducted a randomized, double-blind, placebo-controlled study. Methods Thirty patients with type 2 diabetes on diet therapy were recruited from an outpatient clinic (22 men and 8 women aged 59.10 ± 13.24 years, body mass index: 25.18 ± 3.88, hemoglobin A1c: 7.04 ± 1.24%). They were divided into 2 groups and underwent 2 interventions with a 4-week interval. One group received fucoidan for 12 weeks (a daily 60 mL test beverage containing 1,620 mg of fucoidan) and then placebo (60 mL) for the subsequent 12-week period, while the order was reversed in the other group. Evaluation was performed just before and after each intervention. Taste sensitivity was measured for 5 basic tastes by the filter paper disk method and food intake was evaluated with a validated diet questionnaire. Results No adverse events occurred during the study period. Despite no change of the diet, stool frequency increased during fucoidan intake (from 7.78 ± 4.64/week in Week 1 to 9.15 ± 5.03/week in Week 5, P < 0.001), and it increased more in lean subjects. In 11 subjects whose stool frequency exceeded the mean value, the thresholds for sweet, salty, bitter and umami tastes were significantly reduced (enhancement of sensitivity) after fucoidan intake. In 14 subjects with normal HOMA-IR (homeostatic model assessment of insulin resistance, < 2.5), hemoglobin A1c decreased after fucoidan intake (from 6.73 ± 1.00 to 6.59 ± 1.00%, P < 0.05), as did the fasting plasma level of GLP-1 (glucagon-like peptide-1, from 6.42 ± 3.52 to 4.93 ± 1.88 pmol/L, P < 0.05). Conclusion Sustained fucoidan intake led to alterations of gastrointestinal function, including increased stool frequency and enhanced taste sensitivity, which could contribute to better control of diabetes.

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“…[35][36][37] Therefore, it is concluded that the hypoglycemic potential of ESW is comparable to that in studies previously reported on S. wightii or fucoidan. 38,39 Cholesterol is known to be one of the major lipids that can provide information about lipid metabolism. 40 Previous studies have already reported the hypolipidemic property of sulfated polysaccharides, which could be correlated to the reduction in cholesterol level observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Toxicological Evaluation of <i>Sargassum wightii</i> Greville in Wistar Rats

RAMU¹,

MURALI²,

Anbu³

2019

tjps

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Bu çalışma, Sargassum wightii'nin farklı ekstrelerinde bulunan fitokimyasalları tanımlamak ve etanol ekstresinin toksisitesini değerlendirmek için yapılmıştır. Gereç ve Yöntemler: S. wightii'den total etanol ekstraksiyonu ve ardışık çözücü ekstraksiyonu yapılarak ekstreler üzerinde ön fitokimyasal tarama yapılmıştır. S. wightii'nin etanol ekstresinin (ESW) akut toksisitesi araştırılmıştır. ESW'nin subkronik toksisitesi, 100, 200 ve 400 mg/kg'lik dozlarla test edilmiştir. Hayvanlar, vücut ağırlığındaki ve yiyecek ve su alımındaki değişiklikler için gözlenmiştir. Çalışmanın sonunda, hayati organların relatif ağırlıkları, ardından histopatolojik incelemeler yapılmıştır. Çeşitli hematolojik ve biyokimyasal değerlendirmeler de yapılmıştır. Bulgular: S. wightii'nin fitokimyasal taraması, alkaloitler, karbonhidratlar, glikozitler, fenolik bileşikler ve tanenlerin varlığını ortaya koymuştur. ESW, akut toksisite çalışmasında mortalite veya terminal öncesi ölüme neden olmamıştır. Hayvanlar, vücut ağırlığındaki ve yem ve su tüketimindeki değişiklikler yönünden gözlenmiştir. Çalışmanın sonunda, hayati organların (beyin hariç) relatif ağırlıkları, yem ve su tüketiminde kontrol grubuna kıyasla anlamlı farklılıklar bulunamamıştır. Histopatolojik incelemede patolojik lezyonların olmadığını gösteren normal bir yapı izlenmiştir. Hematolojik ve biyokimyasal parametreler, yararlı olduğu düşünülen glukoz ve kolesterol seviyelerinde azalma haricinde, kontrol grubu ile de karşılaştırılabilir düzeyde bulunmuştur. Sonuç: S. wightii'de çeşitli fitokimyasalların varlığı, farklı hastalıkların tedavisi için potansiyel bir kaynak olabileceğinin kanıtıdır. ESW ile tedaviden sonra önemli bir toksik etki gözlenmemiştir. Bu nedenle, güvenli olduğu ve uzun süreli tedavide kullanılabilirliği önerilmiştir. Anahtar kelimeler: Sargassum wightii, fitokimyasal tarama, akut toksisite, subkronik toksiste Objectives: The present study was conducted to identify the phytoconstituents present in different extracts of Sargassum wightii and to assess the toxicity of its ethanol extract. Materials and Methods: Successive solvent extraction and total ethanol extraction of S. wightii were performed and preliminary phytochemical screening was carried out. The acute toxicity of ethanol extract of S. wightii (ESW) was studied. The subchronic toxicity of ESW was tested with doses of 100, 200, and 400 mg/kg. The animals were observed for changes in body weight and food and water intake. At the end of the study, the relative weights of vital organs were noted, followed by histopathological examinations. Various hematological and biochemical estimations were also carried out. Results: Phytochemical screening of S. wightii revealed the presence of alkaloids, carbohydrates, glycosides, phenolic compounds, and tannins. ESW did not induce any mortality or pre-terminal death in the acute toxicity study. There were no significant differences in body weight, relative weight of vital organs (except the brain), or food or water intake compared to the control group. The histopatho...

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Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4

Cited by 51 publications

References 43 publications

Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice

Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice

A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity

Phytochemical Screening and Toxicological Evaluation of <i>Sargassum wightii</i> Greville in Wistar Rats

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