Fucoidan from Undaria pinnatifida has anti-diabetic effects by stimulation of glucose uptake and reduction of basal lipolysis in 3T3-L1 adipocytes

Sim, Sung-Yi; Shin, Yoo-Lim; Kim, Hyekyeong

doi:10.1016/j.nutres.2019.02.002

Cited by 54 publications

(31 citation statements)

References 36 publications

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“…These findings were parallel with those of Wang et al who concluded that FUC reduces STZ-induced hyperglycemia and kidney damage in rats [53]. The glucose-lowering effect of FUC might be due to enhancement of insulin secretion by pancreatic cells, increasing glucose uptake, or reduction of basal lipolysis [54]. Similarly, FUC improved the liver functions in carbon tetrachloride, microcystin, and diazinon-induced hepatorenal injuries in murine models [55][56][57] and lowered serum AST and ALT activities in hepatitis C virus-infected subjects [58].…”

supporting

confidence: 88%

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Aleissa

Alkahtani

Eldaim

et al. 2020

Oxidative Medicine and Cellular Longevity

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The current study was carried out to evaluate the ameliorative effect of fucoidan against aflatoxicosis-induced hepatorenal toxicity in streptozotocin-induced diabetic rats. Sixty-four Wister albino male rats were randomly assigned into eight groups (8 rats each) that received normal saline, fucoidan (FUC) at 100 mg/kg/day orally for 4 weeks, streptozotocin (STZ) at 50 mg/kg/i.p. single dose, STZ plus FUC, aflatoxin B 1 (AFB 1 ) at 50 μg/kg/i.p. after one month of the beginning of the experiment for 2 weeks, AFB 1 plus FUC, STZ plus AFB 1 , or STZ plus AFB 1 and FUC. Injection of rats with STZ induced hyperglycemia. Rats with STZ-induced diabetes, with or without AFB 1 intoxication, had significantly elevated activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and levels of serum urea, creatinine, cholesterol, 8-oxo-2′-deoxyguanosine, interleukin-1β, interleukin-6, and tumor necrosis factor-α. In addition, these rats exhibited increased lipid peroxidation and reduced glutathione concentration and activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes in the hepatic and renal tissues. In contrast, administration of FUC to diabetic rats, with or without AFB 1 intoxication, ameliorated the altered serum parameters, reduced oxidative stress, DNA damage, and inflammatory biomarkers, and enhanced the antioxidant defense system in the hepatic and renal tissues. These results indicated that FUC ameliorated diabetes and AFB 1 -induced hepatorenal injuries through alleviating oxidative stress, DNA damage, and inflammation.

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supporting

confidence: 88%

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Aleissa

Alkahtani

Eldaim

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Since it is well described that fucoidans directly affect signaling pathways associated with cell surface receptors, it was reassuring to observe that major membrane receptor pathways for growth factors such as BDNF, EGFR/ErbB, and insulin receptor were predicted by the pathway analysis, as well as the associated downstream signaling components such as MAPK. This surface-activity of fucoidan is also reflected by the prediction of fucoidan effects on focal adhesion in the present study, which supports previous observations that low molecular weight fucoidan can attenuate aortic aneurism [15]. Additionally, research into fucoidan effects via MAPK cascade includes curative effects on leishmaniosis [18], affecting M2 type macrophages, inhibiting cancer growth by modulating immune responses [19], and reducing cerebral reperfusion injury [20].…”

Section: Discussionsupporting

confidence: 91%

“…This is illustrated by several related studies. While fucoidan was reported to restore insulin stimulated glucose-uptake in adipocytes in vitro [15], no fucoidan-effects on insulin or glucose control were observed in healthy overweight subjects [16] and in one clinical trial fucoidan even increased insulin resistance [17].…”

Section: Discussionmentioning

confidence: 96%

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

et al. 2020

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Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer-related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function.

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“…In type 2 diabetes, a decrease in muscle mass decreases the metabolic capacity of body which exacerbates the T2DM pathology (Andreassen et al, 2006). Previous studies have already demonstrated that fucoidan can increase insulin-stimulated glucose uptake (Sim et al, 2019) and prevent β-cell dysfunction (Yu et al, 2017). It would be interesting to further investigate the association between fiber type and insulin-stimulated glucose uptake as type 2 muscle fibers show greater insulin-stimulated glucose uptake compared to other fiber types (Mackrell et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Oral fucoidan improves muscle size and strength in mice

et al. 2021

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Fucoidan is a sulfated polysaccharide found in a range of brown algae species. Growing evidence supports the long‐term supplementation of fucoidan as an ergogenic aid to improve skeletal muscle performance. The aim of this study was to investigate the effect of fucoidan on the skeletal muscle of mice. Male BL/6 mice (N = 8–10) were administered a novel fucoidan blend (FUC, 400 mg/kg/day) or vehicle (CON) for 4 weeks. Treatment and control experimental groups were further separated into exercise (CON+EX, FUC+EX) or no‐exercise (CON, FUC) groups, where exercised groups performed 30 min of treadmill training three times per week. At the completion of the 4‐week treatment period, there was a significant increase in cross‐sectional area (CSA) of muscle fibers in fucoidan‐treated extensor digitorum longus (EDL) and soleus fibers, which was accompanied by a significant increase in tibialis anterior (TA) muscle force production in fucoidan‐treated groups. There were no significant changes in grip strength or treadmill time to fatigue, nor was there an effect of fucoidan or exercise on mass of TA, EDL, or soleus muscles. In gastrocnemius muscles, there was no change in mRNA expression of mitochondrial biogenesis markers PGC‐1α and Nrf‐2 in any experimental groups; however, there was a significant effect of fucoidan supplementation on myosin heavy chain (MHC)‐2x, but not MHC‐2a, mRNA expression. Overall, fucoidan increased muscle size and strength after 4 weeks of supplementation in both exercised and no‐exercised mice suggesting an important influence of fucoidan on skeletal muscle physiology.

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Fucoidan from Undaria pinnatifida has anti-diabetic effects by stimulation of glucose uptake and reduction of basal lipolysis in 3T3-L1 adipocytes

Cited by 54 publications

References 36 publications

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

Oral fucoidan improves muscle size and strength in mice

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Fucoidan from Undaria pinnatifida has anti-diabetic effects by stimulation of glucose uptake and reduction of basal lipolysis in 3T3-L1 adipocytes

Cited by 54 publications

References 36 publications

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

Oral fucoidan improves muscle size and strength in mice

Contact Info

Product

Resources

About

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁