2021
DOI: 10.1016/j.ijbiomac.2021.03.110
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Fucoidan induces ROS-dependent epigenetic modulation in cervical cancer HeLa cell

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Cited by 28 publications
(13 citation statements)
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“…Translocation of PS in the outer leaflet of the membrane is the key feature of apoptosis-like cell death in the parasite. It had been reported that many secondary metabolites from plants like apigenin, ferulic acid, gallic acid, and flavonoids induced antileishmanial activity by inducing apoptosis in parasites (Antwi et al, 2019;Mustafa et al, 2021). We observed a similar mechanism of apoptosis in L. donovani promastigotes treated with sesamol.…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…Translocation of PS in the outer leaflet of the membrane is the key feature of apoptosis-like cell death in the parasite. It had been reported that many secondary metabolites from plants like apigenin, ferulic acid, gallic acid, and flavonoids induced antileishmanial activity by inducing apoptosis in parasites (Antwi et al, 2019;Mustafa et al, 2021). We observed a similar mechanism of apoptosis in L. donovani promastigotes treated with sesamol.…”
Section: Discussionsupporting
confidence: 77%
“…We observed remarkable decrease in red/green (590/ 530 nm) fluorescence intensity of JC-1 potentiometric dye, which suggested the collapse of mitochondrial membrane polarization, which would lead to the stress in parasites causing apoptosis-like cell death. Previously, many investigators had also shown a similar mechanism of action of several natural compounds showing antileishmanial activity Mustafa et al, 2021). In multicellular organisms, mitochondria produced superoxide anions and free radicals upon exposure to toxicants, which subsequently oxidized and damaged lipids, proteins, and DNA of the cells (Shadab et al, 2017).…”
Section: Discussionmentioning
confidence: 92%
“…Histone deacetylase 3 (HDAC3) is a form of HDAC. HDAC3 in the use of other types of HDAC homology search was found for the first time [ 9 ], and then, the abnormal expression in multiple myeloma, liver cancer, and other malignant tumors was confirmed [ 10 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…A similar approach was used to understand the anti-viral, antioxidative, and anti-diabetic roles of fucoidan (58)(59)(60). In addition, our result showed a high binding affinity of fucoidan to MMP9, RELA, and PPARD through the formation of hydrogen bonds, suggesting the drug-protein interaction and the antiobesogenic ability of fucoidan (61).…”
Section: Discussionmentioning
confidence: 99%