Fucoidan isolated from <i>Ascophyllum nodosum</i> alleviates gut microbiota dysbiosis and colonic inflammation in antibiotic-treated mice

Wang, Lilong; Ai, Chunqing; Wen, Chengrong; Qin, Yimin; Liu, Zhengqi; Wang, Linlin; Gong, Yue; Su, Changyu; Wang, Zhongfu; Song, Shuang

doi:10.1039/d0fo00668h

Cited by 49 publications

(47 citation statements)

References 51 publications

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“…In contrast, when this complex was injected intraperitoneally, it was unable to reduce disease severity and even deteriorated some colitis markers. In mice, colonic inflammation and microbiota dysbiosis induced by antibiotics was alleviated by administration of fucoidan extracted from Ascophyllum nodosum (400 mg/kg for 28 days) [ 100 ]. Fucoidan prevented colon shortening and colon tissue damage, and it improved abundance of beneficial microbes while decreasing harmful microbes.…”

Section: Brown Seaweed Polysaccharide Supplementationmentioning

confidence: 99%

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Olsthoorn

Wang

Tillema³

et al. 2021

Nutrients

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Multiple health benefits have been ascribed to brown seaweeds that are used traditionally as dietary component mostly in Asia. This systematic review summarizes information on the impact of brown seaweeds or components on inflammation, and inflammation-related pathologies, such as allergies, diabetes mellitus and obesity. We focus on oral supplementation thus intending the use of brown seaweeds as food additives. Despite the great diversity of experimental systems in which distinct species and compounds were tested for their effects on inflammation and immunity, a remarkably homogeneous picture arises. The predominant effects of consumption of brown seaweeds or compounds can be classified into three categories: (1) inhibition of reactive oxygen species, known to be important drivers of inflammation; (2) regulation, i.e., in most cases inhibition of proinflammatory NF-κB signaling; (3) modulation of adaptive immune responses, in particular by interfering with T-helper cell polarization. Over the last decades, several inflammation-related diseases have increased substantially. These include allergies and autoimmune diseases as well as morbidities associated with lifestyle and aging. In this light, further development of brown seaweeds and seaweed compounds as functional foods and nutriceuticals might contribute to combat these challenges.

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Section: Brown Seaweed Polysaccharide Supplementationmentioning

confidence: 99%

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Olsthoorn

Wang

Tillema³

et al. 2021

Nutrients

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“…Defective fucosylation in the gut results in alteration of the microbiota [ 52 ]. Resident microbiota can stimulate fucosylation in the intestine, thus protecting against inflammation and pathogenic infection [ 53 ] Several studies have shown that fucose-containing substances are able to modulate the gut microbiota [ 54 , 55 , 56 ] and ameliorate antibiotic-induced dysbiosis [ 57 ]. Recently we have demonstrated that fucose contributes to amelioration of colitis-associated dysbiosis [ 58 ].…”

Section: Introductionmentioning

confidence: 99%

Fucose Ameliorates Tritrichomonas sp.-Associated Illness in Antibiotic-Treated Muc2−/− Mice

Achasova

Kozhevnikova

Borisova

et al. 2021

IJMS

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The mucus layer in the intestine plays a critical role in regulation of host–microbe interactions and maintaining homeostasis. Disruptions of the mucus layer due to genetic, environmental, or immune factors may lead to inflammatory bowel diseases (IBD). IBD frequently are accompanied with infections, and therefore are treated with antibiotics. Hence, it is important to evaluate risks of antibiotic treatment in individuals with vulnerable gut barrier and chronic inflammation. Mice with a knockout of the Muc2 gene, encoding the main glycoprotein component of the mucus, demonstrate a close contact of the microbes with the gut epithelium which leads to chronic inflammation resembling IBD. Here we demonstrate that the Muc2−/− mice harboring a gut protozoan infection Tritrichomonas sp. are susceptible to an antibiotic-induced depletion of the bacterial microbiota. Suppression of the protozoan infection with efficient metronidazole dosage or L-fucose administration resulted in amelioration of an illness observed in antibiotic-treated Muc2−/− mice. Fucose is a monosaccharide presented abundantly in gut glycoproteins, including Mucin2, and is known to be involved in host–microbe interactions, in particular in microbe adhesion. We suppose that further investigation of the role of fucose in protozoan adhesion to host cells may be of great value.

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“…Interestingly, feeding of fucoidans to mice on a high‐fat diet was correlated with an increase in Akkermansia and protection from metabolic syndrome (Shang et al., 2017). In other mouse studies, fucoidans altered the microbiota selecting for genera such as Bacteroidetes that produce metabolites to protect against insulin resistance (Hu et al., 2019), and promoted growth of beneficial microbes, including Akkermansia, and reduced inflammation following antibiotic treatment (Wang, et al., 2020b). Thus, this group of fucosylated polysaccharides may be a promising functional food for improved gastrointestinal health.…”

Section: Fucose Is An Important Nutrient In Establishing the Microbiotamentioning

confidence: 99%

Significance of fucose in intestinal health and disease

Garber

Hennet

Szymanski

2021

Molecular Microbiology

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The deoxyhexose sugar L‐fucose is important for many biological processes within the human body and the associated microbiota. This carbohydrate is abundant in host gut mucosal surfaces, numerous microbial cell surface structures, and some dietary carbohydrates. Fucosylated oligosaccharides facilitate the establishment of a healthy microbiota and provide protection from infection. However, there are instances where pathogens can also exploit these fucosylated structures to cause infection. Furthermore, deficiencies in host fucosylation are associated with specific disease outcomes. This review focuses on our current understanding of the impact of fucosylation within the mucosal environment of the gastrointestinal tract with a specific emphasis on the mediatory effects in host–microbe interactions.

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Fucoidan isolated from Ascophyllum nodosum alleviates gut microbiota dysbiosis and colonic inflammation in antibiotic-treated mice

Abstract: Fucoidan extracted from Ascophyllum nodosum exhibits beneficial effects on gut microbiota dysbiosis and colonic inflammation induced by ciprofloxacin and metronidazole.

Cited by 49 publications

References 51 publications

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Fucose Ameliorates Tritrichomonas sp.-Associated Illness in Antibiotic-Treated Muc2−/− Mice

Significance of fucose in intestinal health and disease

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