Fucoidan-Mediated Anisotropic Calcium Carbonate Nanorods of pH-Responsive Drug Release for Antitumor Therapy

Wang, Pei; Tong, Fei; Luo, Jun; Li, Zhihua; Wei, Junchao; Liu, Yuangang

doi:10.3389/fbioe.2022.845821

Cited by 7 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the presence of AP (pH 7.4 + AP and pH 6.5 + AP) resulted in an even greater release rate of uPA (52.1% at pH 6.5 in 1 h), indicating that the release of uPA was attributed to both Pkr(Ca/Pda-uPA)-cRGD’s pH responsiveness and selective binding capacity to AP. This could be supported by published studies [ 42 , 43 ].…”

Section: Resultssupporting

confidence: 85%

pH-Responsive Theranostic Colloidosome Drug Carriers Enable Real-Time Imaging of Targeted Thrombolytic Process with Near-Infrared-II for Deep Venous Thrombosis

Ye,

Chen,

Zhang

et al. 2024

Research

View full text Add to dashboard Cite

Thrombosis can cause life-threatening disorders. Unfortunately, current therapeutic methods for thrombosis using injecting thrombolytic medicines systemically resulted in unexpected bleeding complications. Moreover, the absence of practical imaging tools for thrombi raised dangers of undertreatment and overtreatment. This study develops a theranostic drug carrier, Pkr(IR-Ca/Pda-uPA)-cRGD, that enables real-time monitoring of the targeted thrombolytic process of deep vein thrombosis (DVT). Pkr(IR-Ca/Pda-uPA)-cRGD, which is prepared from a Pickering-emulsion-like system, encapsulates both near-infrared-II (NIR-II) contrast agent (IR-1048 dye, loading capacity: 28%) and urokinase plasminogen activators (uPAs, encapsulation efficiency: 89%), pioneering the loading of multiple drugs with contrasting hydrophilicity into one single-drug carrier. Upon intravenous injection, Pkr(IR-Ca/Pda-uPA)-cRGD considerably targets to thrombi selectively (targeting rate: 91%) and disintegrates in response to acidic thrombi to release IR-1048 dye and uPA for imaging and thrombolysis, respectively. Investigations indicate that Pkr(IR-Ca/Pda-uPA)-cRGD enabled real-time visualization of targeted thrombolysis using NIR-II imaging in DVT models, in which thrombi were eliminated (120 min after drug injection) without bleeding complications. This may be the first study using convenient NIR-II imaging for real-time visualization of targeted thrombolysis. It represents the precision medicine that enables rapid response to acquire instantaneous medical images and make necessary real-time adjustments to diagnostic and therapeutic protocols during treatment.

show abstract

Section: Resultssupporting

confidence: 85%

pH-Responsive Theranostic Colloidosome Drug Carriers Enable Real-Time Imaging of Targeted Thrombolytic Process with Near-Infrared-II for Deep Venous Thrombosis

Ye,

Chen,

Zhang

et al. 2024

Research

View full text Add to dashboard Cite

show abstract

“…It is to been emphasized that similar green approaches have been validated previously by Wang et al 99 , Nakayama et al 100 , Babou-Kammoe et al 101 as well as Watanabe et al 102 . More precisely, Wang et al have used Fucoidan-mediated compound with Sodium carbonate in addition to CaCl2 mixed with a fucoidan solutions.…”

Section: Randd Translations: Potential Technological Applicationsmentioning

confidence: 53%

Room temperature bio-engineered multifunctional carbonates for CO2 sequestration and valorization

Mohamed,

Hkiri,

Botha

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This contribution reports, for the first time, on an entirely green bio-engineering approach for the biosynthesis of single phase crystalline 1-D nano-scaled calcite CaCO3. This was validated using H2O as the universal solvent and natural extract of Hyphaene thebaica fruit as an effective chelating agent. In this room temperature green process, CaCl2 and CO2 are used as the unique source of Ca and CO3 respectively in view of forming nano-scaled CaCO3 with a significant shape anisotropy and an elevated surface to volume ratio. In terms of novelty, and relatively to the reported scientific and patented literature in relation to the fabrication of CaCO3 by green nano-chemistry, the current cost effective room temperature green process can be singled out as per the following specificities: only water as universal solvent is used, No additional base or acid chemicals for pH control, No additional catalyst, No critical or supercritical CO2 usage conditions, Only natural extract of thebaica as a green effective chelating agent through its phytochemicals and proper enzematic compounds, room Temperature processing, atmospheric pressure processing, Nanoscaled size particles, and Nanoparticles with a significant shape anisotropy (1-D like nanoparticles). Beyond and in addition to the validation of the 1-D synthesis aspect, the bio-engineered CaCO3 exhibited a wide-ranging functionalities in terms of highly reflecting pigment, an effective nanofertilizer as well as a potential binder in cement industry.

show abstract

“…The seaweed species Fucus vesiculosus, Cladosiphon okamuranus, Laminaria japonica, and Undaria pinnatifida are frequently used to extract the fucoidan used in commercial products. Due to its large number of negatively charged sulfonic acidic groups, fucoidan is considered to be pH sensitive ( Wang et al, 2022 ; Haggag et al, 2023 ). Galactommans are polysaccharides-based macromolecules obtained from plants, microorganisms, animals and algae.…”

Section: Properties Of Non-cellulosic Biological Ph-sensitive Polymermentioning

confidence: 99%

pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery

Vegad,

Patel,

Khunt

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Over the past several decades, there has been significant growth in the design and development of more efficient and advanced biomaterials based on non-cellulosic biological macromolecules. In this context, hydrogels based on stimuli-responsive non-cellulosic biological macromolecules have garnered significant attention because of their intrinsic physicochemical properties, biological characteristics, and sustainability. Due to their capacity to adapt to physiological pHs with rapid and reversible changes, several researchers have investigated pH-responsive-based non-cellulosic polymers from various materials. pH-responsive hydrogels release therapeutic substances in response to pH changes, providing tailored administration, fewer side effects, and improved treatment efficacy while reducing tissue damage. Because of these qualities, they have been shown to be useful in a wide variety of applications, including the administration of chemotherapeutic drugs, biological material, and natural components. The pH-sensitive biopolymers that are utilized most frequently include chitosan, alginate, hyaluronic acid, guar gum, and dextran. In this review article, the emphasis is placed on pH stimuli-responsive materials that are based on biological macromolecules for the purposes of drug administration.

show abstract

Fucoidan-Mediated Anisotropic Calcium Carbonate Nanorods of pH-Responsive Drug Release for Antitumor Therapy

Cited by 7 publications

References 51 publications

pH-Responsive Theranostic Colloidosome Drug Carriers Enable Real-Time Imaging of Targeted Thrombolytic Process with Near-Infrared-II for Deep Venous Thrombosis

pH-Responsive Theranostic Colloidosome Drug Carriers Enable Real-Time Imaging of Targeted Thrombolytic Process with Near-Infrared-II for Deep Venous Thrombosis

Room temperature bio-engineered multifunctional carbonates for CO2 sequestration and valorization

pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery

Contact Info

Product

Resources

About