2023
DOI: 10.1016/j.ijbiomac.2023.125541
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Fucoidan-proanthocyanidins nanoparticles protect against cisplatin-induced acute kidney injury by activating mitophagy and inhibiting mtDNA-cGAS/STING signaling pathway

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Cited by 20 publications
(7 citation statements)
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“…Additionally, the relative expressions of the mitochondrial-related genes, such as mtDNA , CytB , and ND1 , were reduced in DSS-exposed mice, whereas SP remarkably reversed these changes (Figure 6 C-E), indicating that SP restored DSS-induced mitochondrial dysfunction. The mtDNA is unstable and easily released from damaged mitochondria into the cytosol under the influence of oxidative stress 26 . To estimate whether mtDNA was released into the cytosol, we tested and found that DSS treatment increased the circulating levels of mtDNA , CytB , ND1 , and COXII in the serum.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Additionally, the relative expressions of the mitochondrial-related genes, such as mtDNA , CytB , and ND1 , were reduced in DSS-exposed mice, whereas SP remarkably reversed these changes (Figure 6 C-E), indicating that SP restored DSS-induced mitochondrial dysfunction. The mtDNA is unstable and easily released from damaged mitochondria into the cytosol under the influence of oxidative stress 26 . To estimate whether mtDNA was released into the cytosol, we tested and found that DSS treatment increased the circulating levels of mtDNA , CytB , ND1 , and COXII in the serum.…”
Section: Resultsmentioning
confidence: 99%
“…The cGAS-STING pathway is a critical signaling cascade of the innate immune system that is activated upon sensing bacterial DNA or self-DNA, initiating downstream inflammatory factors in the pathological progression of various diseases 25 . The mitochondrial DNA (mtDNA) is released into the cytosol after cellular damage and stress and activates STING signaling via cGAS, resulting in systemic immune response and organ disorder 26 . In particular, the latest studies have reported the involvement of the cGAS-STING signaling pathway in colitis and CLP-induced lethal sepsis 27 , 28 .…”
Section: Introductionmentioning
confidence: 99%
“…This compound is now produced synthetically and has been shown to act on mitochondria by producing ROS and decreasing ∆ψm and ATP concentrations, both in vitro and in vivo. Its citotoxic effect has been demonstrated in leukemia lymphoma models, as well as in many hematological and solid cancers [57,58].…”
Section: Marine Tunicatesmentioning
confidence: 99%
“…Similarly, fucoidan-proanthocyanidin nanoparticles were also reported by the same group, with a similar renal accumulation and therapeutic outcome in a cisplatin-induced AKI model, expanding the application of fucoidans as carriers for complex molecules with condensed rings. 65…”
Section: Natural Polymers For Renal-targeted Deliverymentioning
confidence: 99%