Fucoidan-Rich Substances from Ecklonia cava Improve Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloid β Production/Tau Hyperphosphorylation

Park, Seon Kyeong; Kang, Jin Yong; Kim, Jong Min; Yoo, Seul Ki; Han, Hye Ju; Chung, Dong-Hwa; Kim, Dae‐Ok; Kim, Gun-Hee; Heo, Ho Jin

doi:10.3390/md17100591

Cited by 44 publications

(51 citation statements)

References 55 publications

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“…Fucoidan, an abundant compound derived from marine brown algae, has anti-depressant effects and ameliorated the reduction of BDNF-dependent synaptic plasticity in the hippocampus [86]. In addition, fucoidan from Ecklonia cava showed improvement from learning and memory impairment induced by trimethyltin treatment [87]. In the memory deficit model induced by D-galactose treatment, secondary metabolites of Galactomyces geotrichum from Laminaria japonica shows positive effects on cognitive function [88].…”

Section: Discussionmentioning

confidence: 99%

“…DCX immunoreactivity was quantitatively analyzed using ImageJ software v. 1.50 (National Institutes of Health, Bethesda, MD, USA) as described in previous studies [15,86,87]. Digital image of DCX immunoreactive structures was converted into gray, which has a resolution with 0-255 and the gray intensity and pixel number was measured.…”

Section: Discussionmentioning

confidence: 99%

“…Following the last physical and psychological stress episode, the animals (n = 6-7 in each group) were immediately sacrificed using with a mixture of alfaxalone and xylazine. After subsequent decapitation, the 500-µm-thick hippocampal sections were used for western blot and real-time PCR study as described in a previous study [87]. Briefly, the protein-transferred membrane was sequentially incubated with rabbit anti-BDNF (diluted 1:5000, Abcam), CREB (1:1000; Cell Signaling Technology, Inc., Beverly, MA, USA), or pCREB (1:1000; Cell Signaling Technology, Inc.), peroxidase-conjugated goat anti-rabbit IgG (1:5000, SantaCruz Biotechnology, Santa Cruz, CA, USA), and an ECL chemiluminescent kit (Pierce; Thermo Fisher Scientific, Inc., Waltham, MA, USA).…”

Section: Western Blot and Quantitative Real-time Polymerase Chain Reamentioning

confidence: 99%

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Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

et al. 2020

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Laminaria japonica is widely cultivated in East Asia, including South Korea. Fucoidan, a main component of L. japonica, protects neurons from neurological disorders such as ischemia and traumatic brain injury. In the present study, we examined the effects of extract from fermented L. japonica on the reduction of proliferating cells and neuroblasts in mice that were physically (with electric food shock) or psychologically (with visual, auditory and olfactory sensation) stressed with the help of a communication box. Vehicle (distilled water) or fermented L. japonica extract (50 mg/kg) were orally administered to the mice once a day for 21 days. On the 19th day of the treatment, physical and psychological stress was induced by foot shock using a communication box and thereafter for three days. Plasma corticosterone levels were significantly increased after exposure to physical stress and decreased Ki67 positive proliferating cells and doublecortin immunoreactive neuroblasts. In addition, western blot analysis demonstrated that physical stress as well as psychological stress decreased the expression levels of brain-derived neurotrophic factor (BDNF) and the number of phosphorylated cAMP response element binding protein (pCREB) positive nuclei in the dentate gyrus. Fermentation of L. japonica extract significantly increased the contents of reduced sugar and phenolic compounds. Supplementation with fermented L. japonica extract significantly ameliorated the increases of plasma corticosterone revels and decline in the proliferating cells, neuroblasts, and expression of BDNF and pCREB in the physically stressed mice. These results indicate that fermented L. japonica extract has positive effects in ameliorating the physical stress induced reduction in neurogenesis by modulating BDNF and pCREB expression in the dentate gyrus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Western Blot and Quantitative Real-time Polymerase Chain Reamentioning

confidence: 99%

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Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

et al. 2020

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“…Fucoidan reduced Aβ accumulation, probably by promoting proteasomal activity [ 194 ]. In another study, fucoidan-rich substances from Ecklonia cava improved trimethyltin-induced cognitive dysfunction by inhibiting Aβ production and Tau hyperphosphorylation [ 195 ]. Fucoidan also attenuated transient global cerebral ischemic injury in the gerbil hippocampal CA1 area through mitigating glial activation and oxidative stress [ 196 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

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“…Fucoid component from Dictyota merttensi, Spatoglossum schroederi, and Fucus vesiculosus which contain the inflammation response for their anti-inflammation activity [88]. Lamina japonica has strong antioxidant activity due to the fucoid component in it which inhibits the increased formation of lipid peroxide in serum and liver [89] (Fig. 4).…”

Section: Biological Importance Of the Isolated Compound From The Browmentioning

confidence: 99%

A review on phytoconstituents of marine brown algae

Hakim

Patel

2020

Futur J Pharm Sci

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Background From the last few years, the development and discovery of bioactive compounds and their potential properties from marine algae have been enhanced significantly. The coastal area is a huge storehouse for propitious algae. It has been the genuine reality that the consequence of marine algae as a source of different compounds is increasing. Main body Numerous advanced research devices are available for the discovery of synthetic compounds but still many researchers are working on natural bioactive compounds to discover their biological properties, which are useful to society. Marine algae are taking the preponderance of consideration from investigators owing to its phenomenon of biological activity like anti-cancer, anti-viral, cholesterol-reducing, and many more. A variety of compounds are collected from algae with specific purposes as they remain in an extremely ambitious and hard state; this condition is responsible for the synthesis of very particularly effective bioactive compounds. The present article is concentrating on the brown algae of the Gujarat coast, phlorotannins, polyphenol, phytosterol from brown algae, and their various applications. The main importance has been given to the secondary metabolites and various applications of marine brown algae. Conclusion From this review, it can be concluded that the prominent bioactive compounds from brown algae can cure many serious diseases. Besides, the potential biological activities of a special bioactive compound may represent the interest in the industry of pharmaceuticals, cosmeceutical, and functional foods.

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Fucoidan-Rich Substances from Ecklonia cava Improve Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloid β Production/Tau Hyperphosphorylation

Cited by 44 publications

References 55 publications

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

A review on phytoconstituents of marine brown algae

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