Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice

Abstract

Fucoidan (FCD) is a well-known bioactive constituent of seaweed extract that possess a wide spectrum of activities in biological systems, including anti-cancer, anti-inflammation and modulation of immune systems. However, evidence on the effects of FCD on exercise performance and physical fatigue is limited. Therefore, we investigated the potential beneficial effects of FCD on ergogenic and anti-fatigue functions following physiological challenge. Male ICR mice from three groups (n = 8 per group) were orally administered FCD for 21 days at 0, 310 and 620 mg/kg/day, which were, respectively, designated the vehicle, FCD-1X and FCD-2X groups. The results indicated that the FCD supplementations increased the grip strength (p = 0.0002) and endurance swimming time (p = 0.0195) in a dose-depend manner. FCD treatments also produced dose-dependent decreases in serum levels of lactate (p < 0.0001) and ammonia (p = 0.0025), and also an increase in glucose level (p < 0.0001) after the 15-min swimming test. In addition, FCD supplementation had few subchronic toxic effects. Therefore, we suggest that long-term supplementation with FCD can have a wide spectrum of bioactivities on health promotion, performance improvement and anti-fatigue.

Anti‐fatigue activity of sea cucumber peptides prepared from Stichopus japonicus in an endurance swimming rat model

“…In general, serum creatine kinase concentration is lower in the normal state. At the site of hypoxia and strenuous exercise, creatine kinase activity increases, which results in the reduction of exercise performance . Thus excessive production of LDH and creatine kinase leads to muscle damage and promotes the generation of fatigue .…”

“…At the site of hypoxia and strenuous exercise, creatine kinase activity increases, which results in the reduction of exercise performance. 41 Thus excessive production of LDH and creatine kinase leads to muscle damage and promotes the generation of fatigue. 36,42 BUN concentration reflects the metabolism level of protein and amino acids.…”

Electronic cigarette exposure reduces exercise performance and changes the biochemical profile of female mice

“…A low-force testing system (Model-RX-5, Aikoh Engineering, Nagoya, Japan) was used to measure the forelimb grip strength of treated mice as we previously described [18,19].…”

Supplementation of L‐Arginine, L‐Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice

“…e stored form of glucose is glycogen, which exists mostly in liver and muscle tissues. Liver and muscle tissues were excised after the mice were euthanized and weighed for glycogen content analysis as described previously [21].…”

“…To date, relatively few studies have directly addressed the antifatigue activity of L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract complex (LVFG). In the current study, we used our established in vivo platform [21,22] to evaluate the effects of LVFG supplementation on antifatigue activities and serum nitric oxide levels.…”