Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats

Abdel-Daim, Mohamed M.; Abdeen, Ahmed; Jalouli, Maroua; Abdelkader, Afaf; Megahed, Ameer; Alkahtane, Abdullah A.; Almeer, Rafa; Alhoshani, Norah M.; AL–Johani, Norah S.; Aleya, Lotfi

doi:10.1016/j.scitotenv.2020.144781

Cited by 53 publications

(41 citation statements)

References 37 publications

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“…The results of this study showed that sulfoxaflor did not have toxic effects on kidney function, as evidenced biochemically. Although fucoidan has not been reported to affect serum biochemical markers at low doses in mammals [12,41,42], it significantly decreased the serum AST and LDH activities and BUN levels in the current study. However, fucoidan treatment normalized sulfoxaflor-elevated serum AST and LDH activities.…”

Section: Discussioncontrasting

confidence: 76%

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Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

2021

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Fucoidan is a sulfated polysaccharide which can be found among a number of macroalgea species. It has a broad spectrum of biological activities including anti-oxidant, anti-tumor, immunoregulation, anti-viral and anti-coagulant. The current study was performed to investigate possible protective effects of fucoidan for sulfoxaflor-induced hematological/biochemical alterations and oxidative stress in the blood of male Swiss albino mice. For this purpose, sulfoxaflor was administered at a dose of 15 mg/kg/day (1/50 oral LD50), and fucoidan was administered at a dose of 50 mg/kg/day by oral gavage alone and combined for 24 h and 7 days. Hematological parameters (RBC, HGB, HCT, MCV, MCH, MCHC, Plt, WBC, Neu, Lym and Mon), serum biochemical parameters (AST, ALT, GGT, LDH, BUN, Cre and TBil), and serum oxidative stress/antioxidant markers (8-OHdG, MDA, POC and GSH) were analyzed. The results indicated that sulfoxaflor altered hematological and biochemical parameters and caused oxidative stress in mice; fucoidan ameliorated some hematological and biochemical parameters and exhibited a protective role as an antioxidant against sulfoxaflor-induced oxidative stress.

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Section: Discussioncontrasting

confidence: 76%

“…Rats treated with fucoidan exhibited significantly lower serum ALT, AST, ALP, and LDH activities than rats exposed to diazinon alone [13]. Aflatoxin B1 exposure caused dramatic increases in liver enzymes activities (AST, ALT, ALP and LDH), and fucoidan administration significantly decreased all the measured biochemical parameters [41].…”

Section: Discussionmentioning

confidence: 93%

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

2021

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“…Moreover, SOD is an endogenous enzyme that functions as the initial line of enzymatic defense in mitochondria, rapidly catalyzing dismutase O 2 •− to O 2 and H 2 O 2 ; thereafter, CAT degrades the formed H 2 O 2 to water in a process that helps to quench the induced oxidative damage [ 39 ]. However, in a condition where CAT is exhausted, Fenton’s reaction occurs and produces large amounts of OH • (the most harmful reactive radical), which aggressively attacks the membrane lipids, triggering LPO and formation of MDA [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy

et al. 2021

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CPF (chlorpyrifos) is an organophosphate pesticide used in agricultural and veterinary applications. Our experiment aimed to explore the effects of thymoquinone (TQ) and/or lycopene (LP) against CPF-induced neurotoxicity. Wistar rats were categorized into seven groups: first group served as a control (corn oil only); second group, TQ (10 mg/kg); third group, LP (10 mg/kg); fourth group, CPF (10 mg/kg) and deemed as CPF toxic control; fifth group, TQ + CPF; sixth group, (LP + CPF); and seventh group, (TQ + LP + CPF). CPF intoxication inhibited acetylcholinesterase (AchE), decreased glutathione (GSH) content, and increased levels of malondialdehyde (MDA), an oxidative stress biomarker. Furthermore, CPF impaired the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) along with enhancement of the level of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β. CPF evoked apoptosis in brain tissue. TQ or LP treatment of CPF-intoxicated rats greatly improved AchE activity, oxidative state, inflammatory responses, and cell death. Co-administration of TQ and LP showed better restoration than their sole treatment. In conclusion, TQ or LP supplementation may alleviate CPF-induced neuronal injury, most likely due to TQ or LPs’ antioxidant, anti-inflammatory, and anti-apoptotic effects.

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“…Aflatoxins are carcinogenic mycotoxins produced by Aspergillus fungi, among which aflatoxin B1 (AFB1) is the most toxic and widely present in various foods and feeds and represents a serious risk to human and animal health (1,2). AFB1 produced by moldy feed causes liver, kidney, and other organ damage and inhibits the immune function of the body which considerably affects the growth performance of livestock and poultry, thereby causing huge losses to the livestock and poultry breeding industry globally (3)(4)(5). Moreover, AFB1 and its metabolites (AFM1) may accumulate in meat products, which represents a serious risk to human health (6).…”

Section: Introductionmentioning

confidence: 99%

Penthorum chinense Pursh Compound Ameliorates AFB1-Induced Oxidative Stress and Apoptosis via Modulation of Mitochondrial Pathways in Broiler Chicken Kidneys

Tao

Nabi

et al. 2021

Front. Vet. Sci.

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Aflatoxin B1 (AFB1) is a carcinogenic mycotoxin widely present in foods and animal feeds; it represents a great risk to human and animal health. The aim of this study was to investigate the protective effects of Penthorum chinense Pursh compound (PCPC) against AFB1-induced damage, oxidative stress, and apoptosis via mitochondrial pathways in kidney tissues of broilers. One-day-old chickens (n = 180) were randomly allocated to six groups: control, AFB1 (2.8 mg AFB1/kg feed), positive drug (10 mLYCHT/kg feed), and PCPC high, medium, and low-dose groups (15, 10, and 5 ml PCPC/kg feed, respectively). AFB1 treatment reduced weight gain and induced oxidative stress and kidney damage in broiler tissues; however, PCPC supplementation effectively enhanced broiler performance, ameliorated AFB1-induced oxidative stress, and inhibited apoptosis in the kidneys of broilers. The mRNA expression levels of mitochondria-related apoptosis genes (Bax, Bak, cytochrome c, caspase-9, and caspase-3) were significantly increased, whereas BCL2 expression level decreased in the AFB1 group. Supplementation of PCPC to the AFB1 group significantly reversed the changes in mRNA expression levels of these apoptosis-associated genes compared to those in the AFB1 group. The mRNA levels of NRF2 and HMOX1 in the kidneys of the AFB1 group were significantly reduced compared to those in the control group, whereas PCPC significantly increased the NRF2 and HMOX1 mRNA levels. AFB1 decreased the levels of Beclin1, LC3-I, and LC3-II and increased P53 levels in the kidney compared to those in the control, whereas PCPC significantly reversed these changes to normal levels of autophagy-related genes compared to those in the AFB1 group. In conclusion, our findings demonstrated that PCPC ameliorated AFB1-induced oxidative stress by regulating the expression of apoptosis-related genes and mitochondrial pathways. Our results suggest that PCPC represents a natural and safe agent for preventing AFB1-induced injury and damage in broiler tissues.

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Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats

Cited by 53 publications

References 37 publications

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy

Penthorum chinense Pursh Compound Ameliorates AFB1-Induced Oxidative Stress and Apoptosis via Modulation of Mitochondrial Pathways in Broiler Chicken Kidneys

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