Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Huh, Gyu-Won; Lee, Dae-Young; In, Suh-Ji; Lee, Don-Gil; Park, Sang Yong; Yi, Tae–Hoo; Kang, Hee Cheol; Seo, Woo-Duck; Baek, Nam‐In

doi:10.1007/s13765-012-2069-6

Cited by 21 publications

(24 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The duplicate signals (C-17, C-20, C-22 to C-24, C-27 to C-29) in the 13 C NMR spectrum of 2/3 were in accordance with the occurrence of the two C-24 epimers. Further analysis of 2D NMR data, in particular HMBC and 1 H-1 H COSY spectra allowed corrections of some attributions for the 13 C NMR data of these compounds (Table 1) in comparison with those reported in the literature (Ayyad et al, 2003;Huh et al, 2012). Moreover, after its storage during 24 h at room temperature in an unsealed vial, a further NMR analysis of fucosterol (1) was performed and additional signals were then observed on its 1 H and 13 C NMR spectra.…”

Section: Resultsmentioning

confidence: 76%

“…The chromatographic profile of this sterol fraction showed two main peaks which were separated and obtained in sufficient amounts, by repetitive chromatographic runs, for further NMR study. The complete analysis of the NMR data of the two sub-fractions along with a comparison with literature data allowed their structure to be elucidated as fucosterol (1) (Hwang et al, 2012) and an epimeric mixture of saringosterols (2 and 3) (Ayyad et al, 2003;Catalan et al, 1983;Huh et al, 2012). The duplicate signals (C-17, C-20, C-22 to C-24, C-27 to C-29) in the 13 C NMR spectrum of 2/3 were in accordance with the occurrence of the two C-24 epimers.…”

Section: Resultsmentioning

confidence: 99%

“…Saringosterols have been previously shown to exhibit wide-ranging biological activities (Chen et al, 2014;Hoet et al, 2007;Huh et al, 2012;Kim et al, 2014;Wachter et al, 2001). Fucosterol is highly reactive and its degradation was already mentioned.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Sterols from the brown alga Cystoseira foeniculacea: Degradation of fucosterol into saringosterol epimers

Bouzidi

Viano

Ortalo-Magné

et al. 2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

The present study was carried out in order to determine the phytochemical composition of the marine brown alga Cystoseira foeniculacea collected off the coasts of Algeria. After a preliminary fractionation of its organic crude extracts by column chromatography, the resulting fractions were further analysed by 1 H NMR. Even though algal species of the genus Cystoseira are commonly known to produce a wide variety of meroditerpenoids, in the case of C. foeniculacea none of the fractions were found to contain such compounds: most of the fractions showed typical 1 H NMR signals of fatty acids and derivatives (mainly glycerolipids and glycolipids). Nevertheless, the thorough analysis of a sterol-enriched fraction by RP-C 8 HPLC led to the isolation, for the first time from this species, of fucosterol (1) and a mixture of saringosterols (2 and 3). The NMR data of compounds 1-3 were fully determined with the help of 1D and 2D experiments which allowed the reassignment of some attributions in comparison with those reported in the literature. This work also confirms evidence of the oxidative degradation of fucosterol into a C-24 epimeric mixture of saringosterols. ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

show abstract

Section: Resultsmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Sterols from the brown alga Cystoseira foeniculacea: Degradation of fucosterol into saringosterol epimers

Bouzidi

Viano

Ortalo-Magné

et al. 2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…Fucosterol from Undaria pinnatifida has anti‐osteoporotic effects . In addition, fucosterol derived from Hizikia fusiformis can be used to increase various effects in the osteosarcoma‐derived cell line MG63 …”

Section: Introductionmentioning

confidence: 99%

“…4 In addition, fucosterol derived from Hizikia fusiformis can be used to increase various effects in the osteosarcoma-derived cell line MG63. 5 As shown in Fig. 1, fucosterol is a sterol isolated from brown algae and was first sequestered in its pure form by Heilbron et al, 6 20 years after the first published article highlighting its traits.…”

Section: Introductionmentioning

confidence: 99%

Health benefit of fucosterol from marine algae: a review

et al. 2016

View full text Add to dashboard Cite

Seaweeds belong to a group of marine plants known as algae, which are consumed as sea vegetables in several Asian countries. Recent studies have focused on the biological and pharmacological activities of seaweeds and their highly bioactive secondary metabolites because of their potential in the development of new pharmaceutical agents. Although several varieties of bioactive novel compounds such as phlorotannins, diterpenes and polysaccharides from seaweeds have already been well scrutinized, fucosterol as a phytosterol still needs to reinvent itself. Fucosterol (24-ethylidene cholesterol) is a sterol that can be isolated from algae, seaweed and diatoms. Fucosterol exhibits various biological therapeutics, including anticancer, antidiabetic, antioxidant, hepatoprotective, antihyperlipidemic, antifungal, antihistaminic, anticholinergic, antiadipogenic, antiphotodamaging, anti-osteoporotic, blood cholesterol reducing, blood vessel thrombosis preventive and butyrylcholinesterase inhibitory activities. In this review, we address some potential approaches for arbitrating novel fucosterol biologics in the medical field, focusing on the selection of personalized drug candidates and highlighting the challenges and opportunities regarding medical breakthroughs. We also highlight recent advances made in the design of this novel compound, as the significant health benefits from using these optimized applications apply to the nutraceutical and pharmaceutical fields.

show abstract

Issues Regarding Toxicity and Safety of Foods from Seaweeds

Ferrara

2022

Sustainable Global Resources of Seaweeds Volume 2

View full text Add to dashboard Cite

Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Cited by 21 publications

References 17 publications

Sterols from the brown alga Cystoseira foeniculacea: Degradation of fucosterol into saringosterol epimers

Sterols from the brown alga Cystoseira foeniculacea: Degradation of fucosterol into saringosterol epimers

Health benefit of fucosterol from marine algae: a review

Issues Regarding Toxicity and Safety of Foods from Seaweeds

Contact Info

Product

Resources

About