Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice

Takatani, Naoki; Kono, Yuka; Beppu, Fumiaki; Okamatsu‐Ogura, Yuko; Yamano, Yumiko; Miyashita, Kazuo; Hosokawa, Masashi

doi:10.1016/j.bbrc.2020.05.050

Cited by 40 publications

(46 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, accumulation of lipid droplets and collagen fibres were confirmed by H&E and MT staining, respectively, in the WT-CDAHFD and KO-CDAHFD groups. These observations are consistent with those in previous studies (6,8). Suga et al observed that mice fed with CDAHFD for 6 weeks show hepatic steatosis and fibrosis (8).…”

Section: Discussionsupporting

confidence: 93%

“…In NAFLD and NASH, oxidative stress is enhanced by mitochondrial abnormalities, endoplasmic reticulum stress, and endotoxin action; liver fibrosis progresses through the activation of hepatic stellate cells (5)(6)(7)(8)(9). Renalase has been reported to inhibit oxidative stress (21).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, these inflammatory cytokines are regulated by nuclear factor-κB (NF-κB). Furthermore, the progression of liver fibrosis in NASH is associated with alterations in the extracellular matrix mainly by increased production of type I collagen (5)(6)(7)(8)(9). NASH progresses with increasing degrees of fibrosis, with the most common complication being cirrhosis (2).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model

et al. 2021

View full text Add to dashboard Cite

Progression of nonalcoholic steatohepatitis (NASH) is attributed to several factors, including inflammation and oxidative stress. In recent years, renalase has been reported to suppress oxidative stress, apoptosis and inflammation. A number of studies have suggested that renalase may be associated with protecting the liver from injury. The present study aimed to clarify the effects of renalase knockout (KO) in mice with NASH that were induced with a choline-deficient high-fat diet (CDAHFD) supplemented with 0.1% methionine. Wild type (WT) and KO mice (6-week-old) were fed a normal diet (ND) or CDAHFD for 6 weeks, followed by analysis of the blood liver function markers and liver tissues. CDAHFD intake was revealed to increase blood hepatic function markers, lipid accumulation and oxidative stress compared with ND, but no significant differences were observed between the WT and KO mice. However, in the KO-CDAHFD group, the Adgre1 and Tgfb1 mRNA levels were significantly higher, and α-SMA expression was significantly lower compared with the WT-CDAHFD group. Furthermore, the Gclc mRNA and phosphorylated protein kinase B (Akt) levels were significantly lower in the KO-ND group compared with the WT-ND group. The results of the current study indicated that as NASH progressed in the absence of renalase, oxidative stress, macrophage infiltration and TGF-β expression were enhanced, while α-SMA expression in NASH may be partly suppressed due to the decreased phosphorylation of Akt level.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Increasing evidence suggests that various metabolites from brown seaweeds show anti-inflammatory activities [ 10 , 11 , 12 , 13 ]. Among these, phlorotannins (PTNs) from brown algae, such as Ecklonia cava , have attracted much attention for their clinical applications, including their use as cosmeceuticals [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model

et al. 2020

View full text Add to dashboard Cite

Radiation dermatitis (RD) is one of the most common side effects of radiotherapy; its symptoms progress from erythema to dry and moist desquamation, leading to the deterioration of the patients’ quality of life. Active metabolites in brown seaweed, including phlorotannins (PTNs), show anti-inflammatory activities; however, their medical use is limited. Here, we investigated the effects of PTNs in a mouse model of RD in vivo. X-rays (36 Gy) were delivered in three fractions to the hind legs of BALB/c mice. Macroscopic RD scoring revealed that PTNs significantly mitigated RD compared with the vehicle control. Histopathological analyses of skin tissues revealed that PTNs decreased epidermal and dermal thickness compared with the vehicle control. Western blotting indicated that PTNs augmented nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway activation but attenuated radiation-induced NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and inflammasome activation, suggesting the mitigation of acute inflammation in irradiated mouse skin. PTNs also facilitated fast recovery, as indicated by increased aquaporin 3 expression and decreased γH2AX (histone family member X) expression. Our results indicate that topical PTN application may alleviate RD symptoms by suppressing oxidative stress and inflammatory signaling and by promoting the healing process. Therefore, PTNs may show great potential as cosmeceuticals for patients with cancer suffering from radiation-induced inflammatory side effects such as RD.

show abstract

“…Moreover, it has been demonstrated that fucoxanthin displayed hepatoprotective effects. In particular, anti-fibrogenic activity due to the inhibition of hepatic stellate cell activation has been demonstrated in vitro [ 115 , 116 ], and accordingly the inhibition of hepatic oxidative stress, inflammation, and fibrosis has been observed in vivo after the administration of fucoxanthin in a mouse model of NASH [ 117 ].…”

Section: Bioactive Compounds Of Brown Seaweedsmentioning

confidence: 99%

Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Gabbia

Martin

2020

Molecules

View full text Add to dashboard Cite

Metabolic syndrome is characterized by the coexistence of different metabolic disorders which increase the risk of developing type 2 diabetes mellitus and cardiovascular diseases. Therefore, metabolic syndrome leads to a reduction in patients’ quality of life as well as to an increase in morbidity and mortality. In the last few decades, it has been demonstrated that seaweeds exert multiple beneficial effects by virtue of their micro- and macronutrient content, which could help in the management of cardiovascular and metabolic diseases. This review aims to provide an updated overview on the potential of brown seaweeds for the prevention and management of metabolic syndrome and its associated diseases, based on the most recent evidence obtained from in vitro and in vivo preclinical and clinical studies. Owing to their great potential for health benefits, brown seaweeds are successfully used in some nutraceuticals and functional foods for treating metabolic syndrome comorbidities. However, some issues still need to be tackled and deepened to improve the knowledge of their ADME/Tox profile in humans, in particular by finding validated indexes of their absorption and obtaining reliable information on their efficacy and long-term safety.

show abstract

Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice

Cited by 40 publications

References 34 publications

Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model

Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model

Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Contact Info

Product

Resources

About