Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia

Li, Yuelian; Liu, Lu; Sun, Peilong; Zhang, Yifeng; Wu, Tao; Sun, Han; Cheng, Ka‐Wing; Chen, Feng

doi:10.3390/md18020116

Cited by 29 publications

(26 citation statements)

References 58 publications

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“…Earlier studies suggested that DOX causes inflammatory reactions in the vasculature and myocardium and elevates the concentrations of proinflammatory cytokines (e.g., TNF- α , IL-1 β , and IL-2) [ 50 ]. A critical target for anti-inflammatory action is the Nrf2/HO-1 signaling pathway [ 51 ]. In this study, DOX exposure provoked a host of proinflammatory factors, such as TNF- α , IL-1 β , and IL-6; however, the inflammatory reaction was blunted by choline treatments.…”

Section: Discussionmentioning

confidence: 99%

Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway

Guo

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Choline is a precursor of the major neurotransmitter acetylcholine and has been demonstrated beneficial in diverse models of cardiovascular disease. Here, we sought to verify that choline protects the heart from DOX-induced cardiotoxicity and the underlying mechanisms. The results showed that DOX treatment decreased left ventricular ejection fraction and fractional shortening and increased serum cardiac markers and myocardial fibrosis, which were alleviated by cotreatment with choline. DOX-induced cardiotoxicity was accompanied by increases in oxidative stress, inflammation, and apoptosis, which were rectified by choline cotreatment. Levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1), which are antioxidant markers, were lowered by DOX and upregulated by choline. Moreover, DOX significantly decreased serum acetylcholine levels and the high-frequency component of heart rate variability and increased serum norepinephrine levels and the low-frequency component; these effects were rescued by choline administration. Interestingly, the protective effects of choline could be partially reversed by administration of the muscarinic receptor antagonist atropine. This suggests that choline might be a promising adjunct therapeutic agent to alleviate DOX-induced cardiotoxicity.

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Section: Discussionmentioning

confidence: 99%

Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway

Guo

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Fucoxanthinol is a major gastrointestinal metabolite of dietary fucoxanthin, and to date, the number of natural sources of this compound is reduced, including, for example, the diatom Nitzschia laevis [ 122 , 123 ]. Fucoxanthinol also plays essential roles in the regulation of obesity, and displays relevant health promoting properties, such as antidiabetic, anti-tumoral and anti-inflammatory [ 124 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Biotechnological Value of Marine Invertebrates: A Closer Look at the Biochemical and Antioxidant Properties of Sabella spallanzanii and Microcosmus squamiger

Pan

Rodrigues

Pereira

et al. 2021

Animals

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Sabella spallanzanii and Microcosmus squamiger were profiled for proximate composition, minerals, amino acids, fatty acids (FA), carotenoids, radical scavenging activity on the 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical, oxygen radical absorbance capacity (ORAC) and iron and copper chelating properties. Microcosmus squamiger had the highest level of moisture and crude protein, S. spallanzanii was enriched in crude fat and ash. Both species had similar levels of carbohydrates and energy. There was a prevalence of arginine and glycine in S. spallanzanii, and of taurine in M. squamiger. The most abundant minerals in both species were Na, Ca, and K. The methanol extract of S. spallanzanii had metal chelating properties towards copper and iron, while the methanol extract of M. squamiger was able to chelate copper. M. squamiger extracts had similar ORAC values. Fucoxanthinol and fucoxanthin were the major carotenoids in the M. squamiger dichloromethane extract. Saturated FA were more abundant than unsaturated ones in methanol extracts, and unsaturated FA prevailed in the dichloromethane extracts. Palmitic acid was the predominant FA in methanol extracts, whereas eicosapentaenoic (EPA) and dihomo-γ-linolenic acids were the major compounds in dichloromethane extracts. Low n-6/n-3 ratios were obtained. Our results suggests that both species could be explored as sources of bioactive ingredients with multiple applications.

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“…65 Fucoxanthinol, a carotenoid isolated from Nitzschia laevis protects against neuroinflammatory response in BV-2 microglia. 66 Terpenoids extracted from other S. platensis strains have also been reported for its neuroprotective activities against oxidative stress. 67,68 According to our results, organic solvent extracts showed stronger antioxidant activities than water extract.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

Ngu¹,

Ko²,

Tan³

et al. 2021

IJPER

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Background: In neurological diseases, neuronal loss is frequently associated with overproduction of free radicals and reduced level of endogenous neurotrophic factors. The blue-green microalga, Spirulina platensis is a well-known superfood with a high content of diverse nutrients and possesses several therapeutic properties. Here, we aimed to study the neuritogenic and antioxidant activities of Spirulina platensis UMACC 159. Materials and Methods: PC-12Adh (rat pheochromocytoma) cell was used to investigate the cytotoxicity effect of S. platensis UMACC 159 extracts (water, methanol, and ethanol) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Neuritogenic activity of the extracts towards PC-12Adh cell line was studied using neurite outgrowth assay and immunofluorescence imaging of neurofilaments. The extracts were screened for the phytochemical contents, and antioxidant activities using 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-Diphenyl-1pircrylhydrazyl (DPPH) and reducing power. Results: Ethanol extract was found to exhibit the highest neuritogenic effect and enhanced the cytoskeleton formation in PC-12Adh cells at 6.25 µg/mL. Ethanol extract also showed the highest total phenolic content (49.09 ± 1.35 mg GAE/g), ABTS (EC 50 of 1.34 ± 0.01 mg/mL) and DPPH (EC 50 of 0.45 ± 0.04 mg/mL) scavenging activities (P ≤ 0.05), suggesting that the neuritogenic effect of ethanol extract was attributed to the phenolic compound(s) via antioxidant activity. Conclusion: Ethanol extract contains bioactive compound(s) with similar neuritogenic activity as nerve growth factor for neuronal survival, growth, and axonal regeneration. S. platensis has been proposed as a promising cognitive supplement.

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Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia

Cited by 29 publications

References 58 publications

Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway

Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway

Exploring the Biotechnological Value of Marine Invertebrates: A Closer Look at the Biochemical and Antioxidant Properties of Sabella spallanzanii and Microcosmus squamiger

Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

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