a b s t r a c tThis work presents a numerical method to assess the relative impact of various microstructural features including grain sizes, nanometer scale intragranular gas bubbles, and larger intergranular gas bubbles in irradiated U-Mo metallic fuels on the effective thermal conductivity. A phase-field model was employed to construct a three-dimensional polycrystalline U-Mo fuel alloy with a given crystal morphology and gas bubble microstructures. An effective thermal conductivity ''concept'' was taken to capture the effect of polycrystalline structures and gas bubble microstructures with significant size differences on the thermal conductivity. The thermal conductivity of inhomogeneous materials was calculated by solving the heat transport equation. The obtained results are in reasonably good agreement with experimental measurements made on irradiated U-Mo fuel samples containing similar microstructural features. The developed method can be used to predict the thermal conductivity degradation in operating nuclear fuels if the evolution of microstructures is known during operation of the fuel.Published by Elsevier B.V.