Fufang Zhenzhu Tiaozhi Capsule Ameliorates Hyperuricemic Nephropathy by Inhibition of PI3K/AKT/NF-Κb Pathway

Li, Minghui; Guan, Jian; Chen, Zhe; Mo, Juxian; Wu, Kaireng; Hu, Xuguang; Lan, Tian; Guo, Junpeng

doi:10.2139/ssrn.4085196

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“…A recent study demonstrated that hydroxychloroquine or fufang-zhenzhu-tiaozhi ameliorated renal fibrosis by inhibiting the PI3K/AKT/NF-κB signaling pathway to attenuate inflammatory factors. 56 Thus, Western blotting was carried out to verify the above presumption. As shown in Figure 6F, protein levels of phosphorylation at PI3K, Akt, and NF-κB (p < 0.01) were increased in HUA model mice compared to NC mice, while the p-IκBα levels were decreased.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway

Wang

Liu

Dong

et al. 2023

J. Agric. Food Chem.

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Hyperuricemia (HUA) is a widespread metabolic disease marked by an elevated level of uric acid, and is a risk factor for premature death. The protective effect of corn silk flavonoids (CSF) against HUA and its potential mechanisms were explored. Five important apoptosis and inflammation-related signaling pathways were identified by network pharmacological analysis. The CSF exhibited significant uric acid (UA)-lowering activity in vitro by decreasing xanthine oxidase (XOD) and increasing hypoxanthine–guanine phosphoribosyl transferase levels. In a potassium oxonate-induced HUA in vivo, CSF treatment effectively inhibited XOD activity and promoted UA excretion. Furthermore, it decreased the levels of TNF-α and IL-6 and restored pathological damage. In summary, CSF is a functional food component to improve HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-κB pathway.

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Section: ■ Results and Discussionmentioning

confidence: 99%