Prediction of boiling heat transfer for pool boiling systems is crucial from the viewpoint of safe operation as well as in terms of logical use of energy. Here, five pool boiling processes for calculating the bubble detachment diameters are described. The effects of liquid density and vapor density on the bubble detachment diameter of these pool boiling systems, namely, ethanol, methanol, water, Na 2 SO 4 -water, and NaCl-water, are determined by applying response surface methodology. According to P-values and analysis of variance, there is a good agreement between the obtained regression models for the five pool boiling processes and experimental data for estimation of the bubble detachment diameters.