2021
DOI: 10.1007/s11101-021-09781-1
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Fukinolic acid and cimicifugic acids: a review

Abstract: During the last decades, the research on the biological activities of extracts from Cimicifuga/Actaea species and Petasites japonicus as well as their active ingredients has been intensified. Besides terpenoids as dominant natural product group, hydroxycinnamic acid esters such as fukinolic acid and several cimicifugic acids have been isolated from Actaea and Petasites species and their chemical structures have been elucidated. Investigations on the biological properties of these hydroxycinnamic acid esters ar… Show more

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Cited by 3 publications
(2 citation statements)
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References 110 publications
(140 reference statements)
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“…Further, in Cimicifuga species, a number of phenolic acids have been registered: cimicifugic acids A-N, cimiracemates A-D, and others, which are exclusive chemical constituents of the genus Cimicifuga [47]. These phenolic compounds are formed via the condensation of piscidic acid or fukiic acid with isoferulic, ferulic, caffeic, 3,4dihydroxybenzoic, or some other acids [48]. Further research is needed to verify whether A. macrophylla synthesizes such acids.…”
Section: Phenolic Acidsmentioning
confidence: 99%
See 1 more Smart Citation
“…Further, in Cimicifuga species, a number of phenolic acids have been registered: cimicifugic acids A-N, cimiracemates A-D, and others, which are exclusive chemical constituents of the genus Cimicifuga [47]. These phenolic compounds are formed via the condensation of piscidic acid or fukiic acid with isoferulic, ferulic, caffeic, 3,4dihydroxybenzoic, or some other acids [48]. Further research is needed to verify whether A. macrophylla synthesizes such acids.…”
Section: Phenolic Acidsmentioning
confidence: 99%
“…The flavonols found in A. macrophylla are based on quercetin (40), kaempferol (46), and their derivatives. The following quercetin glycosides were identified in the assayed samples: quercetin-3β-glucoside (45), quercetin-6-O-β-xylopyranosyl-β-glucopyranoside (43), rutin (47), patulitrin (51), narcissin (56), rhamnetin-3-O-xylopyranosyl-glucopyranoside (48), and dihydroquercetin-3-rhamnoside, better known as astilbin (57). Additionally, a flavonoid (40) was found whose aglycone is quercetin that has substituents at positions C-3 and C-7 in the form of hexose sugars, which we were unable to identify.…”
Section: Flavonoidsmentioning
confidence: 99%