Full density fluorescence molecular tomography (FD-FMT) based on a dichroic mirror

Yang, Hao; Dai, Xianjin; Jiang, Huabei

doi:10.1364/ao.57.007938

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Secondly, the imaging process can be simplified by reducing the luminescent projections and collecting x-ray transmission and luminescent data simultaneously. With a limited -view imaging strategy or by adding a mirror (Yang et al 2018), the imaging views can be decreased. Thirdly, more priors may be applied to get better results, such as group sparsity (Jiang et al 2019) or smooth priors like total variation (TV) (Liu et al 2019a).…”

Section: Discussionmentioning

confidence: 99%

Restarted primal–dual Newton conjugate gradient method for enhanced spatial resolution of reconstructed cone-beam x-ray luminescence computed tomography images

Gao¹,

Cheng²,

Schüler³

et al. 2020

Phys. Med. Biol.

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Cone-beam x-ray luminescence computed tomography (CB-XLCT) has been proposed as a promising imaging tool, which enables three-dimensional imaging of the distribution of nanophosphors (NPs) in small animals. However, the reconstruction performance is usually unsatisfactory in terms of spatial resolution due to the ill-posedness of the CB-XLCT inverse problem. To alleviate this problem and to achieve high spatial resolution, a reconstruction method consisting of inner and outer iterations based on a restarted strategy is proposed. In this method, the primal–dual Newton conjugate gradient method (pdNCG) is adopted in the inner iterations to get fast reconstruction, which is used for resetting the permission region and increasing the convergence speed of the outer iteration. To assess the performance of the method, both numerical simulation and physical phantom experiments were conducted with a CB-XLCT system. The results demonstrate that compared with conventional reconstruction methods, the proposed re-pdNCG method can accurately and efficiently resolve the adjacent NPs with the least relative error.

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Section: Discussionmentioning

confidence: 99%

Restarted primal–dual Newton conjugate gradient method for enhanced spatial resolution of reconstructed cone-beam x-ray luminescence computed tomography images

Gao¹,

Cheng²,

Schüler³

et al. 2020

Phys. Med. Biol.

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“…1,2,3 In the optical system, dichroic mirrors are core optical elements, because they can be used to select the spectrum and change the direction of the beam, which determines the detection accuracy and reliability of the instrument. 4 With the development of medical detection technology towards the direction of more accurate and faster, the requirements of core elements are getting higher and higher, and dichroic mirror performance indicators are also getting more and more stringent accordingly. 5…”

Section: Introductionmentioning

confidence: 99%

The high-performance dichroic mirrors for biomedical detection

Ban¹,

Gao²,

Ren³

et al. 2023

Advanced Optical Manufacturing Technologies and Applications 2022; And 2nd International Forum of Young Scientists on Advanced

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Dichroic mirrors, as core optical elements, are widely used in biomedical testing instruments based on the principles of absorbance detection, fluorescence detection and Raman detection. In this paper, the application principle of dichroic mirrors for biomedical detection was introduced, and some key technical indexes for high-performance dichroic mirrors were proposed according to their application characteristics. With the equivalent layer substitution method, a dichroic mirror film system of high-performance based on two conventional materials was designed. Using the plasma assisted reactive magnetron sputtering technology, the dichroic mirror film system with 146 layers was coated, and a kind of dichroic mirror with some important technical indicators such as high steepness (<1%), depolarization (polarization separation <3.5nm), wide range of high transmission (T>96% range > 300nm) was manufactured. The influence of wavefront distortion of dichroic mirror on imaging was described in detail. Our dichroic mirrors can meet the performance of low transmitted wavefront distortion (TWD<λ/4) and low reflected wavefront distortion (RWD<λ/2). The manufactured dichroic mirror products showed satisfying application results when used in high-end medical testing instruments with fine imaging requirements.

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“…As a convenient and cost-effective optical imaging modality, fluorescence molecular tomography (FMT) can overcome the limitations associated with FRI or other planar imaging methods and can provide accurate visualization and quantification of the three-dimensional (3D) distribution of fluorescent targets in deep turbid tissue. In FMT, the 3D spatial distribution of fluorescent probes is quantitatively recovered through a mathematical inverse algorithm using tomographically measured optical data along the boundary of the object [ 11 , 12 , 13 , 14 ]. Today, FMT is widely used in biomedical research and clinical studies, such as cancer imaging, stem cell trafficking, drug delivery, and enzyme activity monitoring [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of a Miniaturized Fluorescence Molecular Tomography (FMT) Endoscope for Breast Cancer Detection Using Targeted Nanoprobes

Yang

Qian

Yang

et al. 2020

IJMS

Self Cite

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In this study, in vivo animal experiments with 12 nude mice bearing breast-cancer-patient-tissue-derived xenograft (PDX) tumors were performed aiming to verify the imaging capability of a novel miniaturized fluorescence molecular tomography (FMT) endoscope, in combination with targeted nanoparticle–near-infrared (NIR) dye conjugates. Tumor-bearing mice were divided into two groups by systematic injection with urokinase plasminogen activator receptor-targeted (n = 7) and nontargeted (n = 5) imaging nanoprobes as a contrast agent, respectively. Each mouse was imaged at 6, 24, and 48 h following the injection of nanoprobes using the FMT endoscope. The results show that systemic delivery of targeted nanoprobes produced a 4-fold enhancement in fluorescence signals from tumors, compared with tumors that received nontargeted nanoprobes. This study indicates that our miniaturized FMT endoscope, coupled with the targeted nanoparticle–NIR dye conjugates as a contrast agent, has high sensitivity and specificity, and thus great potential to be used for image-guided detection and removal of a primary tumor and local metastatic tumors during surgery.

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Full density fluorescence molecular tomography (FD-FMT) based on a dichroic mirror

Cited by 6 publications

References 25 publications

Restarted primal–dual Newton conjugate gradient method for enhanced spatial resolution of reconstructed cone-beam x-ray luminescence computed tomography images

Restarted primal–dual Newton conjugate gradient method for enhanced spatial resolution of reconstructed cone-beam x-ray luminescence computed tomography images

The high-performance dichroic mirrors for biomedical detection

In Vivo Evaluation of a Miniaturized Fluorescence Molecular Tomography (FMT) Endoscope for Breast Cancer Detection Using Targeted Nanoprobes

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