Full-Field and Single-Shot Full-Field Optical Coherence Tomography: A Novel  Technique for Biomedical Imaging Applications

Subhash, Hrebesh M.

doi:10.1155/2012/435408

Cited by 35 publications

(21 citation statements)

References 69 publications

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“…The presented results show a comparable performance to recently published OCT systems. 12,13,23 Some further work is needed to increase the system's speed, which is striven for implementing sinusoidal phase shifting to overcome the low moving step-wise speed of the piezo actuator in the current version of the setup. Furthermore, the specimen needs to be scanned with z-stitching to increase the z measurement range.…”

Section: Resultsmentioning

confidence: 99%

Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

et al. 2015

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The EU-funded project VIAMOS 1 proposes an optical coherence tomography system (OCT) for skin cancer detection, which combines full-field and full-range swept-source OCT in a multi channel sensor for parallel detection. One of the project objectives is the development of new fabrication technologies for micro-optics, which makes it compatible to Micro-Opto-Electromechanical System technology (MOEMS). The basic system concept is a wafer-based Mirau interferometer array with an actuated reference mirror, which enables phase shifted interferogram detection and therefore reconstruction of the complex phase information, resulting in a higher measurement range with reduced image artifacts. This paper presents an experimental one-channel onbench OCT system with bulk optics, which serves as a proof-of-concept setup for the final VIAMOS micro-system. It is based on a Linnik interferometer with a wavelength tuning light source and a camera for parallel A-Scan detection. Phase shifting interferometry techniques (PSI) are used for the suppression of the complex conjugate artifact, whose suppression reaches 36 dB. The sensitivity of the system is constant over the full-field with a mean value of 97 dB. OCT images are presented of a thin membrane microlens and a biological tissue (onion) as a preliminary demonstration.

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Section: Resultsmentioning

confidence: 99%

Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

et al. 2015

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“…The demodulation scheme, novel for FF-OCM, allows the computation of the reflectivity image based on a dual shot image acquisition (by two π-shifted frames) and a monogenic signal calculation 7 . The quadrature component (as monogenic signal component) is determined in a rather isotropic way compared with methods based on directional Hilbert transform 8 . Analogue to the amplitude map also the phase or orientation map of the 2D AM-FM pattern can be determined similar as previously demonstrated in conventional interferometry 9 .…”

Section: Methodsmentioning

confidence: 99%

Full field optical coherence microscopy for material testing: contrast enhancement and dynamic process monitoring

Heise

Schausberger

Buchroithner

et al. 2013

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials

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We illustrate the abilities of an advanced full-field optical coherence microscope (FF-OCM) setup for characterization of technical materials with internal micro-structures and present this technique also for dynamic process monitoring, as strain-stress tests. Additionally we briefly illustrate the potential of image processing in context of the chosen applications. Furthermore, contrast modification techniques based on Fourier plane filtering are discussed.

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“…Coherence properties of laser made a great impact in the field of various optical interferometry, digital holography and optical coherence microscopy/tomography (OCM/T) [1][2][3][4] . Lasers being high temporal coherence (TC) in nature can generate interference pattern quickly in optical interference microscopy systems, which further leads to the measurement of various parameters like phase/height map, refractive index and dry mass density of the biological specimens 5 .…”

Section: Introductionmentioning

confidence: 99%

Relationship between the source size at the diffuser plane and the longitudinal spatial coherence function of the optical coherence microscopy system

Usmani¹,

Ahmad²,

Joshi³

et al. 2019

J. Opt. Soc. Am. A

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Coherence properties and wavelength of light sources are indispensable for optical coherence microscopy/tomography (OCM/T) as they greatly influence the signal to noise ratio, axial resolution, and penetration depth of the system. In the present letter, we investigated the longitudinal spatial coherence properties of pseudo/thermal light source (PTS) as a function of spot size at the diffuser plane, which is controlled by translating microscope objective lens towards or away from the diffuser plane. The axial resolution of PTS is found to be maximum ~ 13 µm for the beam spot size of 3.5 mm at the diffuser plane. The change in the axial resolution of the system as the spot size is increased at the diffuser plane is further confirmed by performing experiments on standard gauge blocks of height difference of 15 µm. Thus, by appropriately choosing the beam spot size at the diffuser plane, any monochromatic laser light source depending on the biological window can be utilized to obtain high axial-resolution with large penetration depth and speckle free tomographic images of multilayered biological specimens irrespective of the source's temporal coherence length. In addition, PTS could be an attractive alternative light source for achieving high axial-resolution without needing chromatic aberration corrected optics and dispersion-compensation mechanism unlike conventional setups.Recently, a number of studies have been put forward to synthesize a spatially extended and temporally coherent light source named pseudo-thermal light source (PTS) to overcome

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Full-Field and Single-Shot Full-Field Optical Coherence Tomography: A Novel Technique for Biomedical Imaging Applications

Cited by 35 publications

References 69 publications

Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

Full field optical coherence microscopy for material testing: contrast enhancement and dynamic process monitoring

Relationship between the source size at the diffuser plane and the longitudinal spatial coherence function of the optical coherence microscopy system

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