Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

Dalimier, Eugénie; Salomon, Denis

doi:10.1159/000337423

Cited by 103 publications

(62 citation statements)

References 49 publications

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“…The cross-sectional (B-scan) mode is the conventional imaging mode in OCT but there are devices which offer the possibility of constructing C-scans (en-face), although not in a real-time manner. New technologies have been developed such as the so-called full-field OCT, which provides 3-dimensional images of biological tissues and has recently been applied mainly in an ex vivo setting [12]. Another innovative technique is the high-definition (HD)-OCT which offers a high lateral and axial resolution of 3 µm and a real-time en-face imaging mode (C-scan).…”

Section: Introductionmentioning

confidence: 99%

High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

et al. 2012

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Background: Demodex mites are involved in different skin diseases and are commonly detected by skin scrape tests or superficial biopsies. A new high-definition optical coherence tomography (HD-OCT) with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode might offer the possibility of noninvasive and fast in vivo examination of demodex mites. Methods: Twenty patients with demodex-related skin diseases and 20 age- and gender-matched healthy controls were examined by HD-OCT. Mites per follicle and follicles per field of view were counted and compared to skin scrape tests. Results: HD-OCT images depicted mites in the en-face mode as bright round dots in groups of 3–5 mites per hair follicle. In the patients with demodex-related disease, a mean number of 3.4 mites per follicle were detected with a mean number of 2.9 infested follicles per area of view compared to a mean of 0.6 mites in 0.4 infested follicles in the controls. The skin scrape tests were negative in 21% of the patients. Conclusion: The innovative HD-OCT enables fast and noninvasive in vivo recognition of demodex mites and might become a useful tool in the diagnosis and treatment monitoring of demodex-related skin diseases.

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Section: Introductionmentioning

confidence: 99%

High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

et al. 2012

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“…FFOCT provides greater contrast and depth of penetration compared to confocal microscopy [12]. FFOCT has been used for diagnosis of fixed and non-fixed tissue samples for the detection of breast, lung and skin and ovarian tissues [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Classification and analysis of human ovarian tissue using full field optical coherence tomography

Nandy

Sanders

Zhu

2016

Biomed. Opt. Express

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Abstract:In this study, a full field optical coherence tomography (FFOCT) system was used to analyze and classify normal and malignant human ovarian tissue. 14 ovarian tissue samples (7 normal, 7 malignant) were imaged with the FFOCT system and five features were extracted by analyzing the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples. A generalized linear model (GLM) classifier was trained using 36 images, and sensitivity of 95.3% and specificity of 91.1% was obtained. 20 images were used to test the model, and a sensitivity of 91.6% and specificity of 87.7% was obtained. Walch, "High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffinembedded tissue," Nat.

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“…FF-OCT has been mostly used for high resolution diverse biomedical applications, such as imaging skin [23], brain tissue [24] and gastrointestinal wall [25], to name a few. For fingerprint imaging applications, FF-OCT has been used to differentiate between real and fake fingerprints [26] and to acquire surface fingerprint images [27].…”

Section: Introductionmentioning

confidence: 99%

Fingerprint imaging from the inside of a finger with full-field optical coherence tomography

Auksorius

2015

Biomed. Opt. Express

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Imaging below fingertip surface might be a useful alternative to the traditional fingerprint sensing since the internal finger features are more reliable than the external ones. One of the most promising subsurface imaging technique is optical coherence tomography (OCT), which, however, has to acquire 3-D data even when a single en face image is required. This makes OCT inherently slow for en face imaging and produce unnecessary large data sets. Here we demonstrate that full-field optical coherence tomography (FF-OCT) can be used to produce en face images of sweat pores and internal fingerprints, which can be used for the identification purposes. 19. E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, "Full-field optical coherence microscopy," Opt. Lett. 23(4), 244-246 (1998 wave imaging to full-field optical coherence shear wave elastography," J.

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Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

Cited by 103 publications

References 49 publications

High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

Classification and analysis of human ovarian tissue using full field optical coherence tomography

Fingerprint imaging from the inside of a finger with full-field optical coherence tomography

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