Full‐field swept‐source optical coherence tomography and neural tissue classification for deep brain imaging

Almog, Ilan Felts; Chen, Fu-Der; Senova, Suhan; Fomenko, Anton; Gondard, Elise; Sacher, Wesley D.; Lozano, Andrés M.; Poon, Joyce K. S.

doi:10.1002/jbio.201960083

Cited by 11 publications

(9 citation statements)

References 56 publications

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“…In a mTESE procedure, the freshly excised testicular tissue can be additionally scanned via FFOCT to confirm the presence of spermatogenesis intraoperatively prior to closing up the main incision. Almog et al developed an endoscopic FFOCT system to perform in vivo neuroimaging experiments of a rat brain 45 , although no similar studies have yet been reported on testicular tissue.…”

Section: Emerging Technologies and Investigationsmentioning

confidence: 99%

Non-obstructive azoospermia: current and future perspectives

Tharakan

Luo

Jayasena

et al. 2021

Fac Rev

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Infertility affects 1 in 6 couples, and male factor infertility has been implicated as a cause in 50% of cases. Azoospermia is defined as the absence of spermatozoa in the ejaculate and is considered the most extreme form of male factor infertility. Historically, these men were considered sterile but, with the advent of testicular sperm extraction and assisted reproductive technologies, men with azoospermia are able to biologically father their own children. Non-obstructive azoospermia (NOA) occurs when there is an impairment to spermatogenesis. This review describes the contemporary management of NOA and discusses the role of hormone stimulation therapy, surgical and embryological factors, and novel technologies such as proteomics, genomics, and artificial intelligence systems in the diagnosis and treatment of men with NOA. Moreover, we highlight that men with NOA represent a vulnerable population with an increased risk of developing cancer and cardiovascular comorbodities.

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Section: Emerging Technologies and Investigationsmentioning

confidence: 99%

Non-obstructive azoospermia: current and future perspectives

Tharakan

Luo

Jayasena

et al. 2021

Fac Rev

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“…It is mainly used in ophthalmology 10 – 13 and in vascular and hemodynamics research 10 , 14 , with some implications in dermatology 15 , 16 , dentistry 17 , 18 , and cancer diagnostics 19 – 23 . Applying OCT to neuroimaging, with or without contrast agents, is gaining increased recognition 24 – 26 .…”

Section: Introductionmentioning

confidence: 99%

Intravital 3D visualization and segmentation of murine neural networks at micron resolution

Lautman

Winetraub

Blacher

et al. 2022

Sci Rep

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Optical coherence tomography (OCT) allows label-free, micron-scale 3D imaging of biological tissues’ fine structures with significant depth and large field-of-view. Here we introduce a novel OCT-based neuroimaging setting, accompanied by a feature segmentation algorithm, which enables rapid, accurate, and high-resolution in vivo imaging of 700 μm depth across the mouse cortex. Using a commercial OCT device, we demonstrate 3D reconstruction of microarchitectural elements through a cortical column. Our system is sensitive to structural and cellular changes at micron-scale resolution in vivo, such as those from injury or disease. Therefore, it can serve as a tool to visualize and quantify spatiotemporal brain elasticity patterns. This highly transformative and versatile platform allows accurate investigation of brain cellular architectural changes by quantifying features such as brain cell bodies’ density, volume, and average distance to the nearest cell. Hence, it may assist in longitudinal studies of microstructural tissue alteration in aging, injury, or disease in a living rodent brain.

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“…Furthermore, a stack of en-face images can then be retrieved, making it possible to reconstruct a three-dimensional amplitude image of biological tissues. An alternative to the full-field direct measurement of the echo time delay of light consists in performing the measurements in the frequency domain by encoding the signal in wavelength 3,4 . However, the acquisition time of the cameras must be adapted, leading to a low signal collection.…”

Section: Introductionmentioning

confidence: 99%

Single-shot off-axis full-field optical coherence tomography

Seromenho

Marmin

Facca

et al. 2022

Preprint

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Full field optical coherence tomography (FF-OCT) enables high-resolution in-depth imaging within turbid media. In this work, we present a simple approach which combines FF-OCT with off-axis interferometry for the reconstruction of the en-face images. With low spatial and temporal coherence illumination, this new method is able to extract an FFOCT image from only one interference acquisition. This method is described and the proof-of-concept is demonstrated through the observation of scattering samples such as organic and ex-vivo biomedical samples.

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Full‐field swept‐source optical coherence tomography and neural tissue classification for deep brain imaging

Cited by 11 publications

References 56 publications

Non-obstructive azoospermia: current and future perspectives

Non-obstructive azoospermia: current and future perspectives

Intravital 3D visualization and segmentation of murine neural networks at micron resolution

Single-shot off-axis full-field optical coherence tomography

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