Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study

Bergamaschi, Cristiane de Cássia; Santamaria, Milton; Berto, Luciana Aranha; Cogo‐Müller, Karina; Motta, Rogério Heládio Lopes; Salum, Erik; Nociti, Francisco Humberto; Goodson, J. Max; Groppo, Francisco Carlos

doi:10.1111/jre.12278

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…That study determined that treatment with minocycline microspheres and metronidazole gel improved PPD and CAL in patients with periodontitis compared to SRP alone (44). Bergamaschi et al compared the effect of metronidazole (local and systemic) as adjunctive therapy to full mouth periodontal debridement in smokers with chronic periodontitis, and concluded that adjunctive use of metronidazole (gel or tablet) to periodontal debridement led to similar clinical and microbiological improvement compared to treatment with placebo + periodontal debridement in smokers with chronic periodontitis up to 6 months after treatment (45). Singh et al conducted a study to comparatively evaluate the efficacy of local delivery of Aloe vera and metronidazole, as an adjunctive therapy to SRP in chronic periodontitis patients.…”

Section: Discussionmentioning

confidence: 99%

Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Farahmand¹,

Sayar²,

Ghourbani³

et al. 2019

Avicenna J Dent Res

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Section: Discussionmentioning

confidence: 99%

Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Farahmand¹,

Sayar²,

Ghourbani³

et al. 2019

Avicenna J Dent Res

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“…Furthermore, PPD levels did not differ signi cantly between the three groups at the beginning of treatment and after three months; In other words, all treatments were equally effective, and no signi cant difference was seen (p > 0.05). Similar to the present study, Bergamaschi et al [14] conducted a pilot clinical trial in Brazil in 2015 to compare the effect of local metronidazole gel or systemic tablet use as adjunctive therapy in line with complete oral debridement in smoker patients with chronic periodontitis. PPD improved in all groups from the rst month to the last evaluation time (P < 0.05).…”

Section: Discussionmentioning

confidence: 83%

Effects of local and systemic metronidazole as adjunctive treatment in chronic periodontitis patients

Barrouz¹,

Houshyar

Jamalnia

et al. 2023

Preprint

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Aim This study aimed to compare the effects of local and systemic metronidazole in patients with chronic periodontitis. Materials and methods In this randomized clinical study, 30 patients (3 teeth per patient) were treated in three groups: SRP treatment alone, metronidazole tablet as adjunctive treatment, and metronidazole gel as adjunctive treatment. BOP (Bleeding on probing), PPD (pocket probing depth), and CAL (clinical attachment level) data were taken at the beginning and three months later. Collected data tested by Wilcoxon test and Kruskal-Wallis. Statistical analysis was performed using SPSS V.21. Results BOP, CAL, and PPD levels were significantly different at the beginning of treatment and after three months, and this was true for all treatments. BOP, CAL, and PPD levels did not differ significantly between the three groups after the treatment. (p > 0.005). Conclusion The effectiveness of these methods was all equal. Accordingly, choosing one of these methods depends on the ease of use, the patient's condition, and the clinician’s opinion. Clinical relevance: Chronic Periodontitis is progressive disease wich can cause tooth loss. The accepted treatment is scaling and root planing (SRP). Antibiotics used systemically can penetrate the depth of the periodontal pockets but have several side effects; Hence, using a kind of less complicated medicinal form in the form of a topical gel as an adjunctive therapy in the treatment of chronic periodontitis can be more effective.

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“…In a study conducted by Dua et al, 34 a combination of metronidazole and norfloxacin applied topically was found to be safe and effective enough to be used as an alternative treatment in local bacterial infection and burn wound healing. Bergamaschi et al, 35 in a study of patients with chronic periodontitis and periodontal debridement, reported that topical and systemic administration of metronidazole produced the same results as the untreated control group. Kadkhoda et al, 36 in a study of patients with aggressive periodontitis and periodontal debridement who received a topical application of metronidazole, found that only periodontal debridement was significantly reduced.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of the Effects of Topical Application of Chlorhexidine, Ozone, and Metronidazole on Palatal Wound Healing: A Histopathological Study

Acıkan

Sayeste

Bozoğlan³

et al. 2021

Journal of Craniofacial Surgery

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: This study aimed to evaluate the effects of chlorhexidine, metronidazole, and ozone application on the healing of palatal wounds in diabetic rats. A defect in the form of a 4 mm-diameter wound was created on the palatal mucosa of 84 adult female Wistar albino rats, which were randomly divided into 4 groups: control, chlorhexidine, metronidazole, and ozone groups. The animals were euthanized after 3, 6, and 10 days, and wound closure was histologically assessed. On day 3, polymorphonuclear leukocytes were significantly higher in the control group than in the chlorhexidine and ozone groups (P < 0.05). Fibrosis was higher in the ozone group than in the control and chlorhexidine groups (P < 0.05). Vascular endothelial growth factor was higher in the metronidazole and ozone groups than in the control group (P< 0.05). On day 6, the quantity of polymorphonuclear leukocytes was higher in the control, metronidazole, and chlorhexidine groups than in the ozone group (P < 0.05). Vascular endothelial growth factor was higher in the ozone group than in the control, chlorhexidine, and metronidazole groups (P < 0.05). On day 10, Vascular endothelial growth factor was higher in the control, chlorhexidine, and metronidazole groups than in the ozone group (P < 0.05). The authors concluded that the use of chlorhexidine, ozone, and metronidazole pastes resulted in enhanced wound healing, as determined histologically. The authors suggest that ozone supplementation can be an alternative therapy to chlorhexidine in impaired wound healing in diabetes mellitus.

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Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study

Cited by 11 publications

References 48 publications

Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Effects of local and systemic metronidazole as adjunctive treatment in chronic periodontitis patients

Evaluation of the Effects of Topical Application of Chlorhexidine, Ozone, and Metronidazole on Palatal Wound Healing: A Histopathological Study

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