Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide

Blanco, Esther; Guerra, Beatriz; Torre, Beatriz G. de la; Defaus, Sira; Dekker, A.; Andreu, David; Sánchez‐Madrid, Francisco

doi:10.1016/j.antiviral.2016.03.005

Cited by 50 publications

(82 citation statements)

References 33 publications

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“…Building upon earlier work (79, 80), Blanco et al (55) reported that a synthetic dendrimeric peptide vaccine comprising two copies of a FMDV VP1 B cell epitope linked to a FMDV 3A T cell epitope protected pigs against disease and virus shedding after two doses of vaccination followed by challenge inoculation with live homologous FMDV O UK 2001 (Table 2). Guo et al (54) have developed a bacterial expression system to generate VLPs of the FMDV Asia 1 capsid proteins.…”

Section: Novel Approaches To Vaccines and Vaccinationmentioning

confidence: 91%

Challenges of Generating and Maintaining Protective Vaccine-Induced Immune Responses for Foot-and-Mouth Disease Virus in Pigs

et al. 2016

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Vaccination can play a central role in the control of outbreaks of foot-and-mouth disease (FMD) by reducing both the impact of clinical disease and the extent of virus transmission between susceptible animals. Recent incursions of exotic FMD virus lineages into several East Asian countries have highlighted the difficulties of generating and maintaining an adequate immune response in vaccinated pigs. Factors that impact vaccine performance include (i) the potency, antigenic payload, and formulation of a vaccine; (ii) the antigenic match between the vaccine and the heterologous circulating field strain; and (iii) the regime (timing, frequency, and herd-level coverage) used to administer the vaccine. This review collates data from studies that have evaluated the performance of foot-and-mouth disease virus vaccines at the individual and population level in pigs and identifies research priorities that could provide new insights to improve vaccination in the future.

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Section: Novel Approaches To Vaccines and Vaccinationmentioning

confidence: 91%

Challenges of Generating and Maintaining Protective Vaccine-Induced Immune Responses for Foot-and-Mouth Disease Virus in Pigs

et al. 2016

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“…The P values were performed using a t test ( * P < .05; ** P < .01; *** P < .001; ns, no significant differences) (b) do not involve infectious viruses; (c) are easy to express and purify on a large scale; and (d) the epitope sequence can be adjusted at any time according to the variation of the epidemic strain, so as to increase the broad-spectrum of the vaccine. 29,30 Several studies have demonstrated effective delivery and display platforms for multiple FMDV epitopes, many of which use VLPs as a presentation system. 14 However, most of these chimeric particles cannot be assembled efficiently and produced on a large scale, which limits their application for subsequent clinical production.…”

Section: Expression and Assembly Of Chimeric Hbc-based Vlps Displaymentioning

confidence: 99%

Artificially designed hepatitis B virus core particles composed of multiple epitopes of type A and O foot‐and‐mouth disease virus as a bivalent vaccine candidate

Yao

Shao

Zhao

et al. 2019

Journal of Medical Virology

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Recently, many countries, including China, have experienced a series of type A and O foot‐and‐mouth disease virus (FMDV) epidemics, causing serious economic losses. Although concerns about the safety of inactivated FMD vaccines have been raised, the development of a safe and effective subunit vaccine is necessary. We constructed two chimeric virus‐like particles (VLPs; rHBc/AO and rHBc/AOT VLPs) displaying tandem repeats of B cell epitopes (VP1 residue 134‐161 and 200‐213) derived from type A and O FMDV and one T cell epitope (3 A residue 21‐35) using the truncated hepatitis B virus core (HBc) carrier. Our results indicate that the chimeric HBc can self‐assemble into VLPs with these FMDV epitopes displayed on the surface. Immunization with the chimeric VLPs induced specific IgG and neutralization antibodies against type A and O FMDV in mice. Compared with the commercial type A/O FMDV bivalent inactivated vaccine, rHBc/AO and rHBc/AOT VLPs significantly stimulated the production of Th1 type cytokines (IFN‐γ and IL‐2), whereas Th2 cytokine production (IL‐4 and IL‐10) was decreased. Compared with rHBc/AO, rHBc/AOT induced increased Th2 cytokine and specific IgG production. These results demonstrate that the VLPs constructed in the current study induced both humoral and cellular immune responses and may represent potential bivalent VLP vaccines targeting both FMDV type A and O strains.

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“…Addition of dendrimer resulted in 4.5-fold greater increase and thus all the mice that underwent rabies virus challenge survived, while in the group treated with formulation without dendrimer only 60% viability was observed. PLL dendrimers were the subject of research by Blanco et al to create a suitable vaccination for swine from foot-and-mouth disease virus [71]. They prepared G0 and G1 PLL dendrimers with T-epitope as a core and B-epitopes as terminal groups.…”

Section: Herpes Simplex Virus (Hsv) and Human Papilloma Virus (Hpv) mentioning

confidence: 99%

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

Mlynarczyk¹,

Kocki²,

Gośliński³

2017

Nanostructured Materials - Fabrication to Applications

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Dendrimers represent a distinct class of polymers-highly branched and uniform, with a relatively small size when compared to their mass. They are composed of the core, from which branched polymeric dendrons diverge and they are end-capped with selected terminal groups. Recently, dendrimers have attracted considerable attention from medicinal chemists, mostly due to their well-defined and easy-to-modify structure. This chapter aims to compile dendrimer applications and activities especially for prevention and fighting off infections caused by bacteria and fungi, viruses, and parasites/protozoa. Our goal in this review is to discuss selected modifications of dendrimers of potential value for pharmaceutical chemistry.

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Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide

Cited by 50 publications

References 33 publications

Challenges of Generating and Maintaining Protective Vaccine-Induced Immune Responses for Foot-and-Mouth Disease Virus in Pigs

Challenges of Generating and Maintaining Protective Vaccine-Induced Immune Responses for Foot-and-Mouth Disease Virus in Pigs

Artificially designed hepatitis B virus core particles composed of multiple epitopes of type A and O foot‐and‐mouth disease virus as a bivalent vaccine candidate

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

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