Full spectrum of COVID-19 severity still being depicted

Zhang, Xu; Li, Shu; Tian, Shujun; Li, Hao; Kong, Lingquan

doi:10.1016/s0140-6736(20)30308-1

Cited by 88 publications

(95 citation statements)

References 2 publications

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“…The COVID-19 pandemic causes panic and mental health problems for the public [17,18], as experienced previously with the Middle-East respiratory syndrome coronavirus (MERS-CoV) [19,20]. Additionally, myths and misinformation about this epidemic, travel bans and executive orders to quarantine travelers might affect the public's psychological health [17,21,22].…”

Section: Backgroundsmentioning

confidence: 99%

People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy

Nguyen

Binh

et al. 2020

JCM

503

486

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The coronavirus disease 2019 (COVID-19) epidemic affects people’s health and health-related quality of life (HRQoL), especially in those who have suspected COVID-19 symptoms (S-COVID-19-S). We examined the effect of modifications of health literacy (HL) on depression and HRQoL. A cross-sectional study was conducted from 14 February to 2 March 2020. 3947 participants were recruited from outpatient departments of nine hospitals and health centers across Vietnam. The interviews were conducted using printed questionnaires including participants’ characteristics, clinical parameters, health behaviors, HL, depression, and HRQoL. People with S-COVID-19-S had a higher depression likelihood (OR, 2.88; p < 0.001), lower HRQoL-score (B, −7.92; p < 0.001). In comparison to people without S-COVID-19-S and low HL, those with S-COVID-19-S and low HL had 9.70 times higher depression likelihood (p < 0.001), 20.62 lower HRQoL-score (p < 0.001), for the people without S-COVID-19-S, 1 score increment of HL resulted in 5% lower depression likelihood (p < 0.001) and 0.45 higher HRQoL-score (p < 0.001), while for those people with S-COVID-19-S, 1 score increment of HL resulted in a 4% lower depression likelihood (p = 0.004) and 0.43 higher HRQoL-score (p < 0.001). People with S-COVID-19-S had a higher depression likelihood and lower HRQoL than those without. HL shows a protective effect on depression and HRQoL during the epidemic.

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Section: Backgroundsmentioning

confidence: 99%

People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy

Nguyen

Binh

et al. 2020

JCM

503

486

View full text Add to dashboard Cite

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“…A sharp increase in confirmed cases was observed on 13 February due to the inclusion of cases with clinical diagnosis (The State Council, The People's Republic of China, 2020b). The current estimated case fatality rate is 1-2% (Guan et al, 2020;Heymann and Shindo, 2020;Lipsitch et al, 2020;The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020;Wang et al, 2020c;Xu et al, 2020d) which varied geographically being higher in Wuhan (2.9%) (The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Wang et al, 2020a). The reproductive number (number of cases that one case can generate) was estimated to be 2.68 (95% CI, 2.47-2.86) and the count is doubling every 6.4 days (95% CI, 5.8-7.1), similar to the early phase of SARS .…”

Section: Introductionmentioning

confidence: 99%

COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese–Western Medicine for the Management of 2019 Novel Coronavirus Disease

2020

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As of 22 February 2020, more than 77662 cases of confirmed COVID-19 have been documented globally with over 2360 deaths. Common presentations of confirmed cases include fever, fatigue, dry cough, upper airway congestion, sputum production, shortness of breath, myalgia/arthralgia with lymphopenia, prolonged prothrombin time, elevated C-reactive protein, and elevated lactate dehydrogenase. The reported severe/critical case ratio is approximately 7-10% and median time to intensive care admission is 9.5-10.5 days with mortality of around 1-2% varied geographically. Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. We have also reviewed the clinical evidence generated from SARS and H1N1 management with hypothesized mechanisms and latest in silico findings to identify candidate Chinese medicines for the consideration of possible trials and management. Given the paucity of strongly evidence-based regimens, the available data suggest that Chinese

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“…The first studies reporting single-center case series of hospitalized patients of COVID-19 showed high rates of admission to intensive care (32%), high mortality (15%) [3], and case fatality rates (CFR) of 4.3% (6/138) [4] and 11% (11/99) [5] in Wuhan, while lower figures were reported outside the city [6]. However, the high CFRs observed in Wuhan are likely to be overestimated, as the cited studies have mainly considered patients with severe symptoms who were hospitalized, excluding mild and asymptomatic patients who are less likely to be admitted to the hospital [7]. The most recent estimation of an overall 2.3% CFR reported by China CDC [8,9] is thus tentative, and more specific figures will remain undetermined until a later point.…”

Section: Introductionmentioning

confidence: 99%

Geo-temporal distribution of 1,688 Chinese healthcare workers infected with COVID-19 in severe conditions—A secondary data analysis

et al. 2020

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IntroductionThe COVID-19 outbreak is posing an unprecedented challenge to healthcare workers. This study analyzes the geo-temporal effects on disease severity for the 1,688 Chinese healthcare workers infected with COVID-19. MethodsUsing the descriptive results recently reported by the Chinese CDC, we compare the percentage of infected healthcare workers in severe conditions over time and across three areas in China, and the fatality rate of infected healthcare workers with all the infected individuals in China aged 22-59 years.

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Full spectrum of COVID-19 severity still being depicted

Cited by 88 publications

References 2 publications

People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy

People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy

COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese–Western Medicine for the Management of 2019 Novel Coronavirus Disease

Geo-temporal distribution of 1,688 Chinese healthcare workers infected with COVID-19 in severe conditions—A secondary data analysis

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