Full Spectrum of Psychiatric Disorders Related to Foreign Migration

Cantor‐Graae, Elizabeth; Pedersen, Carsten Bøcker

doi:10.1001/jamapsychiatry.2013.441

Cited by 148 publications

(135 citation statements)

References 37 publications

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“…The registry studies showed increased incidence for schizophrenia, schizophrenia spectrum disorders and having at least one psychiatric disorder among immigrants and descendants compared to ethnic Danes [25,26]. Refugees had higher overall risks of having a first-time psychiatric contact for mental disorders than did ethnic Danes.…”

Section: Communicable Diseasesmentioning

confidence: 98%

“…Mental Health Almost all studies found a higher risk of mental disorder among immigrants compared with ethnic Danes [2,19,[25][26][27]. The registry studies showed increased incidence for schizophrenia, schizophrenia spectrum disorders and having at least one psychiatric disorder among immigrants and descendants compared to ethnic Danes [25,26].…”

Section: Communicable Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Morbidity, Self-Perceived Health and Mortality Among non-Western Immigrants and Their Descendants in Denmark in a Life Phase Perspective

Jervelund

Malik

Ahlmark

et al. 2016

J Immigrant Minority Health

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To enable preventive policies to address health inequity across ethnic groups, this review overviews the current knowledge on morbidity, self-perceived health and mortality among non-Western immigrants and their descendants in Denmark. A systematic search in PUBMED, SCOPUS, Embase and Cochrane as well as in national databases was undertaken. The final number of publications included was 45. Adult immigrants had higher morbidity, but lower mortality compared to ethnic Danes. Immigrant children had higher mortality and morbidity compared to ethnic Danes. Immigrants' health is critical to reach the political goals of integration. Despite non-Western immigrants' higher morbidity than ethnic Danes, no national strategy targeting immigrants' health has been implemented. Future research should include elderly immigrants and children, preferably employing a life-course perspective to enhance understanding of parallel processes of societal adaptation and health.

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Section: Communicable Diseasesmentioning

confidence: 98%

Section: Communicable Diseasesmentioning

confidence: 99%

Morbidity, Self-Perceived Health and Mortality Among non-Western Immigrants and Their Descendants in Denmark in a Life Phase Perspective

Jervelund

Malik

Ahlmark

et al. 2016

J Immigrant Minority Health

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“…Schizophrenia is a complex syndromic disease 29 with geographically varying prevalence 30 and characterized by a markedly elevated prevalence among first and second generation immigrants 31,32 , particularly among persons with dark skin moving to Nordic lattitudes 33 . These not peer-reviewed) is the author/funder.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive gDNA micro-scale heterogeneity has been documented in the UK 21 and Western France 27 and admixture has been an important factor in the accretion of the present-day genomic variation of Europe 22,28 . The UK study 21 showed that this is not just a result of recent demic changes; however, recent migrations may lead to widespread 2GLD.Schizophrenia is a complex syndromic disease 29 with geographically varying prevalence 30 and characterized by a markedly elevated prevalence among first and second generation immigrants 31,32 , particularly among persons with dark skin moving to Nordic lattitudes 33 . These not peer-reviewed) is the author/funder.…”

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confidence: 99%

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

Hagen

Gonçalves

Hedley

et al. 2017

Preprint

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Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. A reanalysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 normal Danes and 2,538 schizophrenia patients, revealed marked inter-allelic differences in haplogroup affiliation and nuclear ancestry, genogeophraphic affinity (GGA). This bi-genomic linkage disequilibrium (2GLD) could entail population stratification. Only two mitochondrial SNPs, m.15043A and m.15218G, were significantly associated with schizophrenia. However, these associations disappeared when corrected for haplogroup affiliation. The extensive 2GLD documented is a major concern when interpreting historic as well as designing future mtDNA association studies.not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/149070 doi: bioRxiv preprint first posted online 3 Genetic variants in mitochondrial DNA (mtDNA) -and in nuclear genes coding for mitochondrial function -have been associated with disease 1-3 . More than 300 variants 4,5 in mtDNA and genes involved in mitochondrial function 6 have been reported to cause mitochondrial disease which is clinically characterised by complex metabolic, neurological, muscular and psychiatric symptoms 7,8 .SNPs in mtDNA and mitochondrial haplogroups (mtDNA hgs), which are evolutionarily fixed SNP sets with a characteristic geographical distribution, have been proposed as potential disease modifiers 8 . This has been reported in neurological degenerative diseases such as Alzheimer's disease 9-12 and Parkinson's disease 12-14 , metabolic diseases and cancers 15 , as well as psychiatric diseases, notably schizophrenia (SZ) and bipolar disease [16][17][18] .Association studies of mtDNA variants and disease have been difficult to replicate 8 . However, the definition of a methodological paradigm for association studies with mtDNA variants 19 implicitly assumes that mtDNA variants are independent of the nuclear genome. In a recent Danish study on mtDNA haplogroups and their nuclear ancestry or nuclear genogeographical affinity (GGA), we demonstrated a marked difference in nuclear ancestry between individual haplogroups 20 . This means that mtDNA hgs entail population stratification also at the level of gDNA. The effect of such a stratification on disease association, will depend on the admixture structure of the particular population, the population history, epidemiology and genetic epidemiology of the disease, as well as the number of persons included in the study. The extensive fine-scale heterogeneity of gDNA and significant admixture documented in the UK 21 and Europe 22 further increase the risk of spurious false positive associations, if the mtDNA/gDNA interaction is not corrected phenomenon for in association studies.not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The co...

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“…Epidemiological studies have revealed a range of environmental and genetic factors associated with increased risk for schizophrenia. Among these factors are family history of schizophrenia and other mental illnesses, specific genetic variations (Borglum et al, 2013;Demontis et al, 2011;Nyegaard et al, 2010), parental immigration (Pedersen et al, 2012;Cantor-Graae and Pedersen, 2013), urban birth and upbringing (Pedersen and Mortensen, 2001a,b), advanced paternal age (McGrath et al, 2014), intrauterine growth retardation, preterm birth (Byrne et al, 2007), obstetric complication (Cannon et al, 2002), and infections during pregnancy (McGrath et al, 2013;Mortensen et al, 2010Mortensen et al, , 2011Pedersen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia

Nordentoft

Larsen

Pedersen

et al. 2015

Schizophrenia Research

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Full Spectrum of Psychiatric Disorders Related to Foreign Migration

Cited by 148 publications

References 37 publications

Morbidity, Self-Perceived Health and Mortality Among non-Western Immigrants and Their Descendants in Denmark in a Life Phase Perspective

Morbidity, Self-Perceived Health and Mortality Among non-Western Immigrants and Their Descendants in Denmark in a Life Phase Perspective

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia

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