Compared to present experiments, tokamak and stellarator reactors will be subject to higher heat loads, sputtering, erosion and subsequent coating, tritium retention, higher neutron fluxes, and a number of radiation effects. Additionally, neutral beam penetration in tokamak reactors will only be limited to the plasma edge. As a result, several optical, beam-based and magnetic diagnostics of today's plasmas might not be applicable to tomorrow's reactors, but the present discussion suggests that reactors could largely rely on microwave diagnostics, including techniques based on mode conversions and Collective Thomson Scattering.