The along-strike variations of the velocity, thickness, and dip of subducting slabs and the volcano distribution have been observed globally. It is, however, unclear what controls the distribution of volcanoes and the associated magma generation. With the presence of nonuniform volcanism, the Aleutian-Alaska subduction zone (AASZ) is an ideal place to investigate subduction segmentation and its relationship with volcanism. Using full-wave ambient noise tomography, we present a high-resolution 3-D shear wave velocity model of the AASZ for the depths of 15-110 km. The velocity model reveals the distinct high-velocity Pacific slab, the thicker, flatter, and more heterogeneous Yakutat slab, and the northeasterly dipping Wrangell slab. We observe low velocities within the uppermost mantle (at depth <60 km) below the Aleutian arc volcanoes, representing partial melt accumulation. The large crustal low-velocity anomaly beneath the Wrangell volcanic field suggests a large magma reservoir, likely responsible for the clustering of volcanoes. The Denali volcanic gap is above an average-velocity crust but an extremely fast mantle wedge, suggesting the lack of subsurface melt. This is in contrast with the lower-velocity back-arc mantle beneath the adjacent Buzzard Creek-Jumbo Dome volcanoes to the east. The back-arc low velocities associated with the Pacific, the eastern Yakutat, and the Wrangell slabs may reflect subduction-driven mantle upwelling. The structural variation of the downgoing slabs and the overriding plate explains the change of volcanic activity along the AASZ. Our findings demonstrate the combined role of the subducting slab and the overriding plate in controlling the characteristics of arc magmatism. Plain Language Summary The subduction of oceanic plates underneath the continent plate is a complicated, three-dimensional process. The geometry of the downgoing plate and the associated volcanic activity vary along the subduction margin. It is not clearly understood what controls the distribution of arc volcanoes. We utilize an advanced seismic imaging technique to construct a detailed seismic velocity model of the Aleutian-Alaska margin, from crust to the uppermost mantle. The velocity model reveals multiple downgoing slabs, with various seismic velocities, thicknesses, and dip angles. The imaged Pacific slab, Yakutat slab, and Wrangell slab correlate spatially with the Aleutian arc volcanoes, the Buzzard Creek-Jumbo Dome volcanoes, and the Wrangell volcanoes, respectively. The mantle wedge, the wedge-shaped space below the overriding crust and above the downgoing slab, is characterized by different seismic velocities below these three volcanic areas. The Denali volcanic gap, a region with the absence of volcanic activity, is located above a seismically fast mantle wedge and an average crust. There is no melt below this volcanic gap based on our observations. Our findings explain the along-strike variation of volcanic activity along the Aleutian-Alaska subduction zone and demonstrate the combined role of the s...