"Fullarazirman" Nano Water Soluble Fullerene C₆₀-Manganese (II) Tri-Adduct Complex with Anti-Cancer Activity Comparable to Doxorubicin

Abstract

There is continued interest in Nano Carbon Materials (NCMs) and two of these, Fullerene C60 and Graphene have received Nobel prizes. Low solubility in most solvents has been a stumbling block in their industrial use. We report here the successful synthesis of a new water soluble tri-adduct of Fullerene C60 using a two-step procedure to obtain the water soluble s-Tri-(1-aziridino-2, 3-dimethoxy-benzene-5-carboxylato-6-carboxylic acid)-H-Fullerene C60-Manganese (II) Complex ( III ). Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS) and Electron Paramagnetic Resonance (EPR) studies critically helped recognize the presence of an atom of Manganese in the complex. The new complex was also characterized by Ultra violet-Visible (UV-Vis.). Fourier Transform-Infra Red (FT-IR) spectroscopy, Energy Dispersive X-ray analysis (EDAX), Scanning Electron Microscopy (SEM), Thermal Gravimetric Analysis (TGA), and powder X-ray diffraction. The new compound has been shown to possess anti-cancer activity comparable to Doxorubicin, currently the most used anti-cancer drug. This new water soluble Fullerene C60-Manganese (II) tri-adduct complex ( III ) thus holds much promise for the fields of biology, biochemistry, medicine, and materials science.

Fabrication of Superparamagnetic Bimetallic Magnesium Nanoferrite Using Green Polyol: Characterization and Anticancer Analysis in Vitro on Lung Cancer Cell Line A549

“…After 30 min of incubation, the samples were washed with Milli-Q and blown dry under a nitrogen stream. The Scan Asyst Peak Force Tapping mode with 512 samples per line and a typical scan rate of 0.5 Hz was used to capture all pictures at room temperature . All pictures (Figure a–d) were processed with Nanoscope analysis, version 1.4.…”

“…The Scan Asyst Peak Force Tapping mode with 512 samples per line and a typical scan rate of 0.5 Hz was used to capture all pictures at room temperature. 51 All pictures (Figure 4a−d) were processed with Nanoscope analysis, version 1.4. AFM is a 3D imaging method that provides information on the surface topography of MF 600 , MF 700 , MF 800 , and MF 900 nanoparticles.…”