2008
DOI: 10.1016/j.nucmedbio.2007.11.008
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Fully automated [18F]fluorocholine synthesis in the TracerLab MXFDG Coincidence synthesizer

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Cited by 48 publications
(43 citation statements)
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“…• 18 F-fl uorocholine PET/CT indicated lymph node metastases and/or bone metastases in 35 patients (39%).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…• 18 F-fl uorocholine PET/CT indicated lymph node metastases and/or bone metastases in 35 patients (39%).…”
Section: Resultsmentioning
confidence: 99%
“…• Patients with prostate cancer with prostate specifi c antigen (PSA) levels between 20 and 99 ng/mL and/or Gleason score 8 -10 tumours, planned for treatment with curative intent based on routine staging with a negative or inconclusive bone scan, were further investigated with a 18 F-fl uorocholine and a 18 F-fl uoride PET/CT.…”
Section: Methodsmentioning
confidence: 99%
“…Seven studies detailing the radiosynthesis of 18 F-FCH, preclinical and early clinical dosimetry and biodistribution in humans were identified. [20][21][22][23][24][25][26] Clinical studies included six articles for evaluation of local disease, [27][28][29][30][31][32] five articles for evaluation of nodal disease, 30,[33][34][35][36] six articles for bone metastases, including evaluation of treatment response, 30,34,[37][38][39][40] 12 articles for biochemical recurrence 34,[36][37][38][40][41][42][43][44][45][46][47] and two articles evaluating 18 F-FCH in castrate-resistant patients. 39,48 Seven studies evaluated 18 F-FCH for defining intra-prostatic lesions or limited lymph node recurrence for dose-escalated radiotherapy.…”
Section: Methodsmentioning
confidence: 99%
“…24 More recently, fully-automated methods for the radiosynthesis of 18 F-FCH by modifying commercial 18 F-FDG cyclotron synthesizer modules have been described, increasing the clinical feasibility of imaging with this agent. 25,26 18 FCH PET or PET/CT acquisition protocol has been established for PCa imaging, although most authors recognize the need to incorporate a component of early imaging to avoid interference from bladder accumulation. Dynamic acquisition over the pelvis followed by a whole-body PET or PET/CT static acquisition including the pelvis has been proposed as allowing visualization of pelvic disease without interference from bladder uptake (dynamic imaging) while allowing maximum sensitivity for distant disease (delayed whole-body PET or PET/CT).…”
Section: Methodsmentioning
confidence: 99%
“…Imaging 18 F--choline was synthesized according to the method described by Kryza et al [19] using the TracerLab MXFDG module (GE Healthcare, Stockholm, Sweden). PET/CT images were obtained using an integrated PET/CT system (Philips Gemini TF, Philips Medical Systems, Ohio, USA) at the Center for Medical Imaging and Physiology, Skåne University Hospital in Malmö and Lund.…”
Section: It Was Approved By the Research Ethical Review Board At The mentioning
confidence: 99%