Fully automated computer-aided volume estimation system for thyroid planar scintigraphy

Huang, Jia-Yann; Lin, Kun-Ju; Chen, Yung‐Sheng

doi:10.1016/j.compbiomed.2013.07.006

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…An ellipsoid formula has also been used to estimate thyroid volume using ultrasonography in hyperthyroid cats . Despite the widespread use of this ellipsoid formula, however, a multitude of other formulas have been recommended to improve the accuracy for calculation of thyroid volume or thyroid area in normal patients and patients with thyroid disease . Overall, it is clear that no single formula will be able to accurately measure thyroid volume in all cases, especially when applied to highly irregular, invasive, or multinodular thyroid masses…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Quantitative Thyroid Scintigraphy for Diagnosis and Staging of Disease Severity in Cats With Hyperthyroidism: Comparison of the Percent Thyroidal Uptake of Pertechnetate to Thyroid‐to‐salivary Ratio and Thyroid‐to‐background Ratios

Peterson

Guterl

Rishniw

et al. 2016

Vet Radiology Ultrasound

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Thyroid scintigraphy is commonly used for evaluation of cats with hyperthyroidism, with the thyroid-to-salivary ratio (T/S) being the most common method to quantify the degree of thyroid activity and disease. Calculation of thyroid-to-background ratios (T/B) or percent thyroidal uptake of (99m) TcO(-) 4 (TcTU) has only been reported in a few studies. The purpose of this prospective, cross-sectional study was to evaluate a number of quantitative scintigraphic indices as diagnostic tests for hyperthyroidism, including the T/S, three different T/B, TcTU, and estimated thyroid volume. Of 524 cats referred to our clinic for evaluation of suspected hyperthyroidism, the diagnosis was confirmed (n = 504) or excluded (n = 20) based on results of a serum thyroid panel consisting of thyroxine (T4 ), triiodothyronine (T3 ), free T4 (fT4 ), and thyroid-stimulating hormone (TSH) concentrations. In the hyperthyroid cats, median values for TcTU, T/S, and three T/B ratios were all significantly higher (P < 0.001) than values in euthyroid suspect cats or clinically normal cats. All scintigraphic parameters were relatively sensitive and specific as diagnostic tests for hyperthyroidism, but the T/S ratio had the highest test accuracy. The T/S ratio correlated strongly with the TcTU (r = 0.85). However, the TcTU had a higher and more significant correlation (P < 0.01) with serum T4 (r = 0.76 vs. 0.64), T3 (r = 0.77 vs. 0.64), and estimated thyroid volume (r = 0.62 vs. 0.38). Overall, calculation of TcTU is an accurate diagnostic test, but also appears to be the best parameter to predict the functional volume and metabolic activity of the feline adenomatous thyroid gland.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Quantitative Thyroid Scintigraphy for Diagnosis and Staging of Disease Severity in Cats With Hyperthyroidism: Comparison of the Percent Thyroidal Uptake of Pertechnetate to Thyroid‐to‐salivary Ratio and Thyroid‐to‐background Ratios

Peterson

Guterl

Rishniw

et al. 2016

Vet Radiology Ultrasound

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“…22 In order to correct this overestimation in volume, the use of various filtering and thresholding methods has been suggested. 48,51 Most studies in both humans and cats have used a region-ofinterest threshold value of 20-30% to improve the accuracy of thyroid volume calculations, 24,48,[51][52][53] similar to the cutoff value of 20% used in this study. We believe that our method of thyroid tumor measurement, followed by use of an equation (prolate spheroid) suitable for thyroid tumors that are spherical-to-cylindrical, 26 provided an acceptable estimate of tumor volume; in support of that, the tumor volumes reported in the 2096 cats of this study (median 1.8 cm 3 ; mean 2.4 cm 3 ) compare fairly well with those of another recent study of 32 hyperthyroid cats in which ultrasound was used as the gold standard to determine thyroid volume (mean tumor volume 2.01 cm 3 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and degree of thyroid pathology in hyperthyroid cats increases with disease duration: a cross-sectional analysis of 2096 cats referred for radioiodine therapy

Peterson

Broome²,

Rishniw

2015

Journal of Feline Medicine and Surgery

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“…Thyroid gland size in grams was calculated using the Allen and Goodwin formula. [11] Actual dosage of I-131 treatment for each study group as stated above was then calculated using the formula: [12,13] …”

Section: Methodsmentioning

confidence: 99%

Finding the best effective way of treatment for rapid I-131 turnover Graves’ disease patients

Thamcharoenvipas

Kerr²,

Tepmongkol

2019

Medicine

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Background: Rapid I-131 turnover Graves’ disease patients have low cure rate. We aimed to compare cure percentage at 12 months among 3 treatment doses of I-131 with or without lithium carbonate (LiCO 3 ) in rapid turnover Graves’ disease patients. Methods: Sixty Graves’ disease patients referred for radioactive iodine treatment were randomised into three arms of treatment: Group A, 3.7 MBq I-131/g thyroid plus 600 mg/day LiCO 3 , Group B, 5.55 MBq I-131/g plus 600 mg/day LiCO 3 , and Group C, 7.4 MBq I-131/g without LiCO 3 . Data were collected at baseline, 3, 6, 9, and 12 months. The primary endpoint were cure rates (percentage of euthyroid or hypothyroid) at 12 months. Pairwise comparisons were made across 3 groups using an equality of proportions test. The secondary endpoint, the odds of cure over the total follow-up for group B and C versus group A, was analyzed using generalized estimating equation (GEE). Side effects of I-131 and LiCO 3 treatment were evaluated at 1 to 2 weeks after treatment. Results: The cure rate at 12 months was 45% (9/20) for group A, 60% (12/20) for group B and 80% (16/20) for group C. The mean difference in proportion cured at 12 months between group C and group A was 35 (7.0 to 66.8)%; P -value = .02. There was a statistically significant difference between cure rates over all follow-up of group C and A after adjustment for sex (adjusted OR = 3.09; 95%CI = 1.32–7.20; P -value = .009), but no significant difference was found between group B and A or C and B in the primary and/or secondary efficacy endpoints. Side effects from the treatment were found in 12% (7/60); 2 in group A, 4 in group B, and 1 in group C. Four of these were likely due to LiCO 3 side effects. Conclusions: Treatment of rapid turnover Graves’ disease patients with high dose I-131 (7.4 MBq/g) provides significantly higher cure rates at 12 months, and 3 times odds of cure than 3.7 MBq/g I-131 plus LiCO 3 with lesser side effects. We thus recommend 7.4 MBq I-131/g for treatment in these patients.

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Fully automated computer-aided volume estimation system for thyroid planar scintigraphy

Cited by 9 publications

References 18 publications

Evaluation of Quantitative Thyroid Scintigraphy for Diagnosis and Staging of Disease Severity in Cats With Hyperthyroidism: Comparison of the Percent Thyroidal Uptake of Pertechnetate to Thyroid‐to‐salivary Ratio and Thyroid‐to‐background Ratios

Evaluation of Quantitative Thyroid Scintigraphy for Diagnosis and Staging of Disease Severity in Cats With Hyperthyroidism: Comparison of the Percent Thyroidal Uptake of Pertechnetate to Thyroid‐to‐salivary Ratio and Thyroid‐to‐background Ratios

Prevalence and degree of thyroid pathology in hyperthyroid cats increases with disease duration: a cross-sectional analysis of 2096 cats referred for radioiodine therapy

Finding the best effective way of treatment for rapid I-131 turnover Graves’ disease patients

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