Fully automated detection of heart irradiation in cine MV images acquired during breast cancer radiotherapy

Poulsen, Per Rugaard; Thomsen, M.S.; Hansen, Rune; Worm, E.; Spejlborg, Harald; Offersen, Birgitte Vrou

doi:10.1016/j.radonc.2019.11.006

Cited by 12 publications

(12 citation statements)

References 19 publications

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“…Poulsen et al [18] designed an algorithm based on changes in pixel intensity due to the heartbeat to automatically detect the heart edge in MV cine images of breast tangents. The retrospective study demonstrated the high efficiency of the algorithm for heart exposure detection.…”

Section: Discussionmentioning

confidence: 99%

First clinical experience with real-time portal imaging-based breath-hold monitoring in tangential breast radiotherapy

Vasina

Kong

Greer

et al. 2022

Physics and Imaging in Radiation Oncology

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Section: Discussionmentioning

confidence: 99%

First clinical experience with real-time portal imaging-based breath-hold monitoring in tangential breast radiotherapy

Vasina

Kong

Greer

et al. 2022

Physics and Imaging in Radiation Oncology

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“…When our study results of DIBH are applied to the above study, cardiac dose can rise up to 3.23 Gy and 2.20 Gy under condition of 5 mm deep set-up error, respectively. Automated heart edge detection in cine MV image has been proposed [17]. If such technology is commercialized, adaptive radiotherapy could be applied to systematically monitor cardiac dose so that cardiac dose can be controlled below the constraint of each institution.…”

Section: Discussionmentioning

confidence: 99%

Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer

2021

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Purpose Breast radiotherapy set-up is often uncertain. Actual dose distribution to normal tissues could be different from planned dose distribution. The objective of this study was to investigate such difference in dose distribution according to the extent of set-up error in breast radiotherapy. Materials and methods A total of 50 Gy with fraction size of 2 Gy was given to 30 left breasts with different set-ups applying a deep inspiration breath holding (DIBH) or a free breathing (FB) technique. Under the assumption that errors might come from translational axes of deep or caudal directions, the isocenter was shifted from the original tangential alignment every 2.5 mm to simulate uncertainty of deep and caudal tangential set-up in DIBH and FB. Changes were evaluated for dosimetric parameters for the heart, the left ventricle (LV), the left anterior descending coronary artery (LAD), and the ipsilateral lung. Results On the original plan, mean doses of heart and ipsilateral lung were 2.0 ± 1.1 Gy and 3.7 ± 1.4 Gy in DIBH and 8.4 ± 1.3 Gy and 7.8 ± 1.5 Gy in FB, respectively. The change of dose distribution for the heart in DIBH was milder than that in FB. The deeper the tangential set-up, the worse the heart, LV, LAD, and ipsilateral lung doses, showing as much as 49.4%, 56.4%, 90.3%, and 26.1% shifts, respectively, in 5 mm DIBH setup. The caudal set-up did not show significant dose difference. In multiple comparison of DIBH, differences of mean dose occurred in all 7.5 mm deep set-ups for the heart (p = 0.025), the LV (p = 0.049), and LAD (p = 0.025) in DIBH. Conclusions To correct set-up error over indicated limitation for deep tangential set-up in DIBH at 5 mm action level, mean heart and ipsilateral lung doses are expected to increase approximately 50% and 25%, respectively.

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“…Automated heart edge detection in cine MV image has been proposed. (14) If such technology is commercialized, adaptive radiotherapy could be applied to systematically monitor cardiac dose so that cardiac dose can be controlled below the constraint of each institution.…”

Section: Discussionmentioning

confidence: 99%

Variation of Heart and Lung Radiation Doses According to Setup Uncertainty in Left Breast Cancer

Park

Rim

Yoon

2020

Preprint

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PurposeBreast radiotherapy set-up is often uncertain. Actual dose distribution to normal tissues could be different from planned dose distribution. The objective of this study was to investigate such difference in dose distribution according to the extent of set-up error in breast radiotherapy.Materials and methodsA total of 50 Gy with fraction size of 2 Gy was given to 30 left breasts with different set-ups applying a deep inspiration breath holding (DIBH) or a free breathing (FB) technique. Under the assumption that errors might come from translational axes of deep or caudal directions, the isocenter was shifted from the original tangential alignment every 2.5 mm to simulate uncertainty of deep and caudal tangential set-up in DIBH and FB. Changes were evaluated for dosimetric parameters for the heart, the left ventricle (LV), the left anterior descending coronary artery (LAD), and the ipsilateral lung.ResultsOn the original plan, mean doses of heart and ipsilateral lung were 2.0 ± 1.1 Gy and 3.7 ± 1.4 Gy in DIBH and 8.4±1.3 Gy and 7.8±1.5 Gy in FB, respectively. The change of dose distribution for the heart in DIBH was milder than that in FB. The deeper the tangential set-up, the worse the heart, LV, LAD, and ipsilateral lung doses, showing as much as 49.4%, 56.4%, 90.3%, and 26.1% shifts, respectively, in 5 mm DIBH setup. The caudal set-up did not show significant dose difference. In multiple comparison of DIBH, differences of mean dose occurred in all 7.5 mm deep set-ups for the heart (p = 0.025), the LV (p = 0.049), and LAD (p = 0.025) in DIBH.ConclusionsTo correct set-up error over indicated limitation for deep tangential set-up in DIBH at 5 mm action level, mean heart and ipsilateral lung doses are expected to increase approximately 50% and 25%, respectively.

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Fully automated detection of heart irradiation in cine MV images acquired during breast cancer radiotherapy

Cited by 12 publications

References 19 publications

First clinical experience with real-time portal imaging-based breath-hold monitoring in tangential breast radiotherapy

First clinical experience with real-time portal imaging-based breath-hold monitoring in tangential breast radiotherapy

Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer

Variation of Heart and Lung Radiation Doses According to Setup Uncertainty in Left Breast Cancer

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