Fully Autonomous System-on-Board with Complex Permittivity Sensors and 60 GHz Transmitter for Biomedical Implant Applications

Issakov, Vadim; Heine, Carl; Lammert, Vincent; Stoegmueller, J.; Meindl, Manfred; Stubenrauch, U.; Geissler, C.

doi:10.1109/rfic49505.2020.9218295

Cited by 8 publications

(2 citation statements)

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“…The possibility to transfer the readout data wirelessly would make the system portable, and it could be even placed in an incubator, which is essential for the measurement of specific proteins, due to the requirement of regulated temperature. Some examples of an autonomous implantable integrated CMOS chip are given in [ 70 ]. Examples of building blocks required for building a wireless data communication link can be found in [ 71 , 72 , 73 ].…”

Section: Methods For Manufacturing Microfluidic Structures For Biosen...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

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Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.

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Section: Methods For Manufacturing Microfluidic Structures For Biosen...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

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“…21(b), consumes 36 mW from a 1.5-V supply and occupies a die area of 1.8 mm 2 . Based on this IC, an 18 × 14-mm systemon-board for the fully autonomous implantable continuous monitoring of biomaterials has been realized [143]. It includes a ball-grid array packaged chip, two of the aforementioned 24-GHz complex sensing oscillators, a temperature sensor, wakeup timer, serial-peripheral interface, ADC, and a finite state machine.…”

Section: Invasive and Implanted Sensorsmentioning

confidence: 99%