2024
DOI: 10.1101/2024.05.28.596248
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival ofMAPTMutation iPSC-derived Neurons

Lianna D’Brant,
Natasha Rugenstein,
Su Kyoung Na
et al.

Abstract: Tau protein aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease, frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP), spurring development of tau-lowering therapeutic strategies. Here, we report fully human bifunctional anti-tau-PEST intrabodies that bind the mid-domain of tau to block aggregation and degrade tau via the proteasome using the ornithine decarboxylase (ODC) PEST degron. They effectively reduced tau protein in human iPSC-derived cortica… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 94 publications
0
0
0
Order By: Relevance