Fully integrated and automated centrifugal microfluidic chip for point-of-care multiplexed molecular diagnostics

Xiao, Yujin; Zhou, Mengfan; Liu, Changgen; Gao, Siyu; Wan, Chao; Li, Shunji; Dai, Chenxi; Du, Wei; Feng, Xiaojun; Li, Yiwei; Chen, Peng; Liu, Bi-Feng

doi:10.1016/j.bios.2024.116240

Cited by 13 publications

(1 citation statement)

References 51 publications

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“…13–16 This innovation arranges microfluidic channels and reaction chambers on a rotating disk, harnessing the mechanical effects of centrifugal force, Coriolis force, and Euler force generated during disk rotation. 17–21 This enables precise manipulation and operation of samples and reagents. 22–30…”

Section: Introductionmentioning

confidence: 99%

Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid

Li,

Wan,

Xiao

et al. 2024

Lab Chip

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Section: Introductionmentioning

confidence: 99%

Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid

Li,

Wan,

Xiao

et al. 2024

Lab Chip

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Biosensor‐Based Microfluidic Platforms for Rapid Clinical Detection of Pathogenic Bacteria

Hou,

Liu,

Huang

et al. 2024

Adv Funct Materials

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Pathogenic bacteria are commonly found in food, water, and soil, posing significant public health challenges globally. Therefore, early, rapid, and highly sensitive strategies for monitoring the bacterial proliferation are crucial for ensuring public health, medical diagnosis, and food safety. Compared to traditional techniques, microfluidic platforms provide powerful detective tools characterized by high integration, high throughput, ease of operation, low reagent consumption, and high sensitivity. Driven by substantial commercial demand, research and development in microfluidic‐based rapid detection methods and technologies has progressed significantly derived by the interdisciplinary integration of multiple disciplines. In this review, progress in clinical detection of pathogenic bacteria with microfluidic biosensors, including microfluidic devices for point‐of‐care (POC) testing, is summarized. Strategies for pathogenic bacteria detection, containing their advantages and disadvantages are discussed in detail. Advanced platforms for capturing and detecting pathogenic bacteria, such as microchannels, microarrays, digital microfluidics (DMF) and paper‐based platforms, are highlighted. The accomplishments and shortcomings of these microfluidic devices are also summarized. Additionally, case studies of biosensor‑based microfluidic devices used for detecting diseases caused by bacterial imbalances are listed. Finally, possible research perspectives for further development in highly effective biosensor‑based microfluidics for clinical detection of pathogenic bacteria are proposed.

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Hydrophilic/hydrophobic modified microchip for detecting multiple gene doping candidates using CRISPR-Cas12a and RPA

Zheng,

Yan,

et al. 2024

Biosensors and Bioelectronics

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Fully integrated and automated centrifugal microfluidic chip for point-of-care multiplexed molecular diagnostics

Cited by 13 publications

References 51 publications

Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid

Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid

Biosensor‐Based Microfluidic Platforms for Rapid Clinical Detection of Pathogenic Bacteria

Hydrophilic/hydrophobic modified microchip for detecting multiple gene doping candidates using CRISPR-Cas12a and RPA

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