Fully Loaded Micromotors for Combinatorial Delivery and Autonomous Release of Cargoes

Sattayasamitsathit, Sirilak; Kou, Huanhuan; Gao, Wei; Thavarajah, Walter; Kaufmann, Kevin; Zhang, Liangfang; Wang, Joseph

doi:10.1002/smll.201303646

Cited by 88 publications

(78 citation statements)

References 19 publications

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“…These applications, collectively, have demonstrated NP-gels as a new and robust class of biomaterials with significant potential to improve drug delivery efficiency. Together with the development of NP-gels, nanoparticles have also been combined with other biomaterial platforms and devices, such as nanofibers, 8, 79, 102 microneedle patches, 15, 16 and nanomotors, 81, 104 leading to more sophisticated drug delivery systems.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

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Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

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Section: Discussionmentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

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“…Recently, self‐propelled chemically powered micromotors have emerged as an exciting tool in nanotechnology . These microdevices can be used to perform complex tasks such as cargo delivery and environmental cleaning . This is particularly desired when remediation tasks have to be performed at remote locations.…”

Section: Methodsmentioning

confidence: 99%

Dual Effect of Manganese Oxide Micromotors: Catalytic Degradation and Adsorptive Bubble Separation of Organic Pollutants

Wani

Safdar

Kinnunen

et al. 2015

Chemistry A European J

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Manganese oxide (MnO2 ) based micromotors exhibiting a dual effect, that is, catalytic degradation and adsorptive bubble separation, were employed for water remediation. The dual effect of MnO2 microparticles led to a greater than 90 % of decolorization of non-biodegradable organic dyes in just 1 h, without the need for external agitation or bubble generation. These findings suggest high potential of MnO2 micromotors for decontamination of organic pollutants from wastewaters or natural water reserves.

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“…5). 41 Such an acid-powered bubble-propelled micromotor possesses several distinct functions for potential biomedical use. These include remarkably high loading capacity, combinatorial delivery of a multitude of cargoes, autonomous release of encapsulated payloads, and selfdestruction.…”

Section: 56mentioning

confidence: 99%

Synthetic micro/nanomotors in drug delivery

2014

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Nanomachines offer considerable promise for the treatment of diseases. The ability of man-made nanomotors to rapidly deliver therapeutic payloads to their target destination represents a novel nanomedicine approach. Synthetic nanomotors, based on a multitude of propulsion mechanisms, have been developed over the past decade toward diverse biomedical applications. In this review article, we journey from the use of chemically powered drug-delivery nanovehicles to externally actuated (fuel-free) drug-delivery nanomachine platforms, and conclude with future prospects and challenges for such practical propelling drug-delivery systems. As future micro/nanomachines become more powerful and functional, these tiny devices are expected to perform more demanding biomedical tasks and benefit different drug delivery applications.

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Fully Loaded Micromotors for Combinatorial Delivery and Autonomous Release of Cargoes

Cited by 88 publications

References 19 publications

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Dual Effect of Manganese Oxide Micromotors: Catalytic Degradation and Adsorptive Bubble Separation of Organic Pollutants

Synthetic micro/nanomotors in drug delivery

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