Fully Natural Lecithin Encapsulated Nano-Resveratrol for Anti-Cancer Therapy

Liang, Meiyi; Guo, Mingyan; Saw, Phei Er; Yao, Yandan

doi:10.2147/ijn.s362418

Cited by 17 publications

(7 citation statements)

References 28 publications

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“… 79 Encapsulation and controlled release of RES using different carriers have emerged as promising strategies to overcome the limitation of low bioavailability. 80 Jhaveri et al 81 first used transferrin-modified polyethylene glycol liposomes (Tf-RES-L) as a delivery system for RES. Compared with free drugs, functionalized drug-loaded liposomes significantly increased apoptosis of glioblastoma multiforme cells (GBMs) by activating the caspase 3/7 pathway.…”

Section: Polyphenolsmentioning

confidence: 99%

Nano-Drug Delivery Systems Based on Natural Products

Lv,

Li,

Liao

et al. 2024

IJN

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Natural products have proven to have significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, and treatment. Compared with synthetic drugs, natural products not only have diverse structures but also exhibit a range of biological activities against different disease states and molecular targets, making them attractive for development in the field of medicine. Despite advancements in the use of natural products for clinical purposes, there remain obstacles that hinder their full potential. These challenges include issues such as limited solubility and stability when administered orally, as well as short durations of effectiveness. To address these concerns, nano-drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. These systems offer notable advantages, such as a large specific surface area, enhanced targeting capabilities, and the ability to achieve sustained and controlled release. Extensive in vitro and in vivo studies have provided further evidence supporting the efficacy and safety of nanoparticle-based systems in delivering natural products in preclinical disease models. This review describes the limitations of natural product applications and the current status of natural products combined with nanotechnology. The latest advances in nano-drug delivery systems for delivery of natural products are considered from three aspects: connecting targeting warheads, self-assembly, and co-delivery. Finally, the challenges faced in the clinical translation of nano-drugs are discussed.

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Section: Polyphenolsmentioning

confidence: 99%

Nano-Drug Delivery Systems Based on Natural Products

Lv,

Li,

Liao

et al. 2024

IJN

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“…Furthermore, integrating RES with gold and silver nanoparticles amplified its antibacterial and anticarcinogenic properties [64]. Recently, when RES was encapsulated in lecithin, known as Nano-RES, it proved effective in combating breast cancer in vitro, specifically targeting BT474 human breast cancer cells [73].…”

Section: Overview Of Resveratrolmentioning

confidence: 99%

Chemopreventive and Anticancer Role of Resveratrol

Zamanian,

Shahbazi,

AL-Ghamdi

et al. 2024

Preprint

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Non-melanoma skin cancer (NMSC) encompasses various skin malignancies, primarily basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Extended exposure to environmental elements, particularly solar ultraviolet (UV) radiation, triggers oxidative stress in skin tissues, resulting in DNA damage that is instrumental in the initiation and progression of NMSC. The imbalance between pro-inflammatory and anti-inflammatory cytokines plays a significant role in the development and progression of skin cancer. Resveratrol (RES), an organic phytoalexin present in grape skins and seeds, demonstrates promising chemopreventive and anti-neoplastic capabilities against NMSC. This research revealed that the synergistic lipid-nanocarrier incorporating RES and 5-FU showed significantly enhanced effectiveness in curtailing the proliferation of malignant cells, notably in the A431 cell line, in comparison to traditional formulations. Moreover, the study illustrated that the RES and 5-FU amalgamation exerted a combined effect in hindering cellular proliferation and triggering apoptosis in cancerous cells, as evidenced in both in vitro and in vivo experiments. Furthermore, RES is known for its antioxidant attributes, which may alleviate the impact of ROS triggered by UV exposure, thus diminishing DNA impairment and mutations. These observations imply that RES might offer chemopreventive benefits for NMSC through its role in apoptosis and mitigating oxidative stress. This research offers critical insights into the prospective utility of RES as a safer, more effective intervention for NMSC, though additional investigations are required to thoroughly decipher the underlying molecular mechanisms and clinical implications.

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“…The size and zeta potential of Scramble-LNP (morphine) and Tet1-LNP (morphine) were determined using Zetasizer nano ZS90 (Malvern Instruments, UK). 25 LNPs morphology were visualized using transmission electron microscopy (TEM; FEI Tecnai G2 12, Eindhoven, Netherlands).…”

Section: Characterization Of Lnpsmentioning

confidence: 99%

TET1-Lipid Nanoparticle Encapsulating Morphine for Specific Targeting of Peripheral Nerve for Pain Alleviation

Yang,

Liu,

Liu

et al. 2024

IJN

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Background: Opioids are irreplaceable analgesics owing to the lack of alternative analgesics that offer opioid-like pain relief. However, opioids have many undesirable central side effects. Restricting opioids to peripheral opioid receptors could reduce those effects while maintaining analgesia. Methods: To achieve this goal, we developed Tet1-LNP (morphine), a neural-targeting lipid nanoparticle encapsulating morphine that could specifically activate the peripheral opioid receptor in the dorsal root ganglion (DRG) and significantly reduce the side effects caused by the activation of opioid receptors in the brain. Tet1-LNP (morphine) were successfully prepared using the thin-film hydration method. In vitro, Tet1-LNP (morphine) uptake was assessed in differentiated neuron-like PC-12 cells and dorsal root ganglion (DRG) primary cells. The uptake of Tet1-LNP (morphine) in the DRGs and the brain was assessed in vivo. Von Frey filament and Hargreaves tests were used to assess the antinociception of Tet1-LNP (morphine) in the chronic constriction injury (CCI) neuropathic pain model. Morphine concentration in blood and brain were evaluated using ELISA. Results: Tet1-LNP (morphine) had an average size of 131 nm. Tet1-LNP (morphine) showed high cellular uptake and targeted DRG in vitro. CCI mice treated with Tet1-LNP (morphine) experienced prolonged analgesia for nearly 32 h compared with 3 h with free morphine (p < 0.0001). Notably, the brain morphine concentration in the Tet1-LNP (morphine) group was eight-fold lower than that in the morphine group (p < 0.0001). Conclusion:Our study presents a targeted lipid nanoparticle system for peripheral neural delivery of morphine. We anticipate Tet1-LNP (morphine) will offer a safe formulation for chronic neuropathic pain treatment, and promise further development for clinical applications.

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Fully Natural Lecithin Encapsulated Nano-Resveratrol for Anti-Cancer Therapy

Cited by 17 publications

References 28 publications

Nano-Drug Delivery Systems Based on Natural Products

Nano-Drug Delivery Systems Based on Natural Products

Chemopreventive and Anticancer Role of Resveratrol

TET1-Lipid Nanoparticle Encapsulating Morphine for Specific Targeting of Peripheral Nerve for Pain Alleviation

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