Fulminant guillain-barré syndrome with myocarditis

Mishra, Ajay Kumar; Dave, Nikhil; Mehta, M.

doi:10.4103/2249-4863.130335

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…A systematic study of the chief complaint of GBS is warranted for the following reasons. Firstly, chief complaints, the most significant symptoms reported by patients are not always in parallel with the results of physical examinations [ 4 , 5 ]. Empirically, for most of the time chief complaints reflect the most significant part of the clinical manifestations, and for some time, chief complaints contain symptoms that could not be found by physical examinations.…”

Section: Introductionmentioning

confidence: 99%

The usefulness of chief complaints to predict severity, ventilator dependence, treatment option, and short-term outcome of patients with Guillain-Barré syndrome: a retrospective study

et al. 2017

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BackgroundIt remains an urgent need for early recognition of disease severity, treatment option and outcome of Guillain-Barré syndrome (GBS). The chief complaint may be quickly obtained in clinic and is one of the candidates for early predictors. However, studies on the chief complaint are still lacking in GBS. The aim of the study is to describe the components of chief complaints of GBS patients, and to explore association between chief complaints and disease severity/treatment option/outcome of GBS, so as to aid the early prediction of the disease course and to assist the clinicians to prescribe an optimal early treatment.MethodsA total of 523 GBS patients admitted to the First Hospital of Jilin University from 2003 to 2013 were enrolled for retrospective analysis. The data of chief complaints, clinical manifestations, and treatment options, etc. were collected. The clinical severity was evaluated by the Medical Research Council sum score and the Hughes Functional Grading Scale. The prognosis at 6 month after discharge was described by modified Erasmus GBS outcome score. The clinic GBS severity evaluation scale (CGSES), a newly established model in our study, was used to explore the role of chief complaints to predict intravenous immunoglobulin (IVIg).ResultsThe major components of the chief complaints of GBS patients were weakness, numbness, pain, cranial nerve involvement, dyspnea, ataxia and autonomic dysfunction. Chief complaint of weakness was a predictor of severe disease course and poor short-term outcome, while chief complaint of numbness and cranial nerve involvement were promising predictors. Cranial nerve involvement was the predictor of ventilator dependence. The percentages of 366 GBS patients, who need IVIg treatment at nadir with CGSES ranging from 1 to 4, were 50.00, 67.34, 80.61, and 90.67%, respectively.ConclusionsChief complaints are clinic predictors of disease severity, ventilator dependence and short-term outcome. IVIg treatment during hospitalisation could be predicted in clinic using CGSES score.

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Section: Introductionmentioning

confidence: 99%

The usefulness of chief complaints to predict severity, ventilator dependence, treatment option, and short-term outcome of patients with Guillain-Barré syndrome: a retrospective study

et al. 2017

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“…[6] Studies have reported that viral infection might be associated with Guillain-Barre syndrome and SPS. [17–22] Evidence of a respiratory viral infection was not found in this patient. Nevertheless, the inflammatory response to an infectious process should not be ignored, and a cytokine storm might be responsible for myocardial injury and nerve injury.…”

Section: Discussionmentioning

confidence: 76%

Fulminant Myocarditis Complicated by Stiff-person Syndrome: A Case Report

Chen,

Tang,

Zhang

et al. 2024

Cardiology Discovery

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This case report described a 61-year-old woman who presented with dizziness, headache, muscle ache, diplopia, and vomiting who lost consciousness. Upon hospital admission, the levels of high-sensitivity cardiac troponin I and partial pressure of carbon dioxide were increased markedly. Loss of consciousness occurred twice after removal of invasive ventilator support. Coronary angiography demonstrated no stenosis in coronary arteries. Ultrasonography revealed inactivity of respiratory muscles. Oculomotor disturbance and autonomic-nerve dysfunctions were observed. Serum antibody against glutamic acid decarboxylase was positive. The rare phenotypes of persistent stiffness of muscles in the neck, face, bilateral upper and lower limbs were observed. The patient was diagnosed with fulminant myocarditis complicated by Stiff-person syndrome. Immunomodulatory treatment (glucocorticoids and immunoglobulins) elicited satisfactory therapeutic effects. In this case report, it was found that fulminant myocarditis and Stiff-person syndrome shared a common pathogenesis: “cytokine storm”. Such patients may benefit from early treatment with immunomodulatory agents.

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