Fulminant ischaemic colitis with atypical clinical features complicating sickle cell disease

Abstract

Clinically significant ischaemic bowel injury is an exceedingly rare complication of sickle cell disease. It manifests as acute surgical abdomen and may respond to conservative treatment. An unusual fatal case of ischaemic colitis with minimal abdominal findings in a young male during a sickle cell vaso-occlusive pain crisis is described. This case demonstrates that an acute surgical abdomen should be considered in such patients who fail to respond to conservative management as untreated this condition may be fatal.

Ogilvie's syndrome in sickle cell disease

“…However, neuropsychiatric side effects, such as depression, cognitive disturbances, anxiety, mania, and psychotic states (1), and more rarely, movement and extrapyramidal disorders, such as chorea, parkinsonism, akathisia, dystonia, and myoclonus, can be observed (2). We report herein choreiform movements associated with the use of PEG-IFN-α 2b in a patient with chronic HCV.…”

“…Interferon (IFN)-α-induced choreiform movements were reported in five cases (2,(4)(5)(6)(7). Two of these cases were treated with PEG-IFN-α for HCV (2,4).…”

“…Two of these cases were treated with PEG-IFN-α for HCV (2,4). In these reports, only one patient had a prior history of HD (4).…”

“…Vasoocclusive phenomena may involve every organ system in the body as well as the gastrointestinal system. Abdominal complications in SCD usually accompany vasoocclusive painful crisis, and are likely the result of ischemia of the mesentery and abdominal viscera (2). To our knowledge, there are two previous reports of Ogilvie's syndrome complicating SCD (3,4).…”

“Recurrent Lower Abdomen Pain, An Introspection.”

“…Perforation-Peptic Ulcer, Typhoid Ulcer, Diverticular Disease, Ulcerative Colitis etc. [52,53,54,55] 5. Tortion Of Pedicle e.g Twisted Ovarian Cyst, Spleen etc.…”