Fulminant myocarditis and atrial fibrillation in child with acute COVID-19

Kohli, Utkarsh; Meinert, Elizabeth; Chong, Grace; Tesher, Melissa; Jani, Priti

doi:10.1016/j.jelectrocard.2020.10.004

Cited by 18 publications

(27 citation statements)

References 19 publications

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“…Cardiac involvement has also been reported in a cohort of European children. 24 Evidence shows that hypoxia and electrolyte imbalance in the acute phase of the disease is linked to cardiac arrhythmias, 25 while raised inflammatory markers like IL‐1β, IFN‐γ, and IL‐6 are associated with myocardial injury. 24 These factors may have caused impaired cardiac function in our children.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of COVID‐19 positive children from a tertiary healthcare hospital in Karachi

Shahid

Raza

Junejo

et al. 2021

Journal of Medical Virology

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As the coronavirus disease 2019 (COVID‐19) pandemic continues to evolve, differences in epidemiological and clinical features among pediatrics have been noticed across different countries. We describe the spectrum of COVID‐19 in pediatric patients treated in tertiary health care. We conducted a retrospective chart review of pediatric patients admitted to Indus Hospital & Health care network, Korangi campus, Karachi; from April 1st, 2020 to July 31st, 2020. A total of 141 COVID‐19 cases were reported, males were 81 (57%) and the median age was 8 (0.3–17) years. Moderate and severe infections were noted in 36(26%), and 17(12%) children respectively. Fever (50%) was the most common clinical feature. The SF ratio less than 264 was significantly associated with severe disease (p < .05). Lab investigations that differed significantly across disease severity groups included IL‐6 levels (p < .01) and Prothrombin time (p < .05). Majority of children were advised home isolation 89 (63%), 29 (20.5%) were admitted while mortality was observed in 10 (7%) children. No significant difference was observed between children with and without malignancy. Pre‐existing comorbidities are significantly associated with COVID‐19 infections among children. Reduced SF ratio, elevated Prothrombin time, and interleukin‐6 levels are associated with greater disease severity.

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Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of COVID‐19 positive children from a tertiary healthcare hospital in Karachi

Shahid

Raza

Junejo

et al. 2021

Journal of Medical Virology

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“…44 In 3 patients who made a full recovery, new-onset arrhythmias developed (2 complete atrioventricular block and 1 atrial fibrillation). 50 , 62 , 81 In 1 case, the patient developed septic shock and disseminated intravascular coagulation. 64 One patient had a stroke several days after being discharged in stable condition following a myocarditis episode.…”

Section: Long-term Consequences Of Covid-19-related Injury and Myocar...mentioning

confidence: 99%

The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury

Siripanthong

Asatryan

Hanff

et al. 2022

JACC: Basic to Translational Science

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The mechanisms of coronavirus disease 2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.

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“…Son zamanlarda nadir vakalar şeklinde akut fulminan miyokardit tabloları bildirilmiş olup bu hastalar yoğun bakım servislerinde tedavi gerektirmiştir. Bu hastalarda solunum semptomları gelişmeden akut miyokardit tablosu gelişmektedir (9)(10)(11)(12). Bu vakaların hepsinde ciddi sol ventrikül yetmezliği gelişmiş ve çeşitli inotrop tedavilerin yanında intravenöz immünoglobulin (IVIG) ve steroid tedavileri almışlardır.…”

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“…Kesici ve ark. 'larının yayınladığı fatal seyreden fulminan miyokarditli bir infantta extracorporeal membrane oxygenation (ECMO) uygulanmış ancak hasta kaybedilmiştir (9). Postmortem yapılan histolojik incelemede lokal inflamasyon ile birlikte miyokard dokusunda viral genomun varlığı dikkat çekmiştir.…”

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Çocuklarda Covi̇d-19 Enfeksi̇yonunda Kalp Tutulumu,

Keskin

2021

SDÜ Tıp Fakültesi Dergisi

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Dünya Sağlık Örgütü (DSÖ) tarafından 11 Mart 2020 tarihinde salgın olarak ilan edilen ve "Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)" olarak isimlendirilen "Coronavirus Disease 2019 (CO-VID-19)" çocuklarda genellikle hafif seyretmektedir. Nisan 2020'de Birleşik Krallık'taki Pediatrik Yoğun Bakım Derneği, belirgin gastrointestinal semptomları ve miyokardiyal tutulum da dahil olmak üzere toksik şok sendromu ve atipik Kawasaki hastalığı ile örtüşen olağandışı bir klinik tablo ile başvuran çocuklar hakkında bir uyarı yayınladı. Bu tarihten sonra Avrupa'da çeşitli merkezlerde buna benzer vakalar bildirilmeye başlandı. DSÖ 14 Mayıs 2020 tarihinde bu olguları pediatrik multisistemik inflamatuvar sendrom (MIS-C) olarak tanımlamıştır. Çocuklarda hafif seyretmekle birlikte COVID-19 hastalığı MIS-C tablosuna yol açtığında ölümcül olabilmektedir. Özellikle kalp tutulumu MIS-C hastalarının çoğunda görüldüğünden erken tanı ve tedavisi önem arz etmektedir. Bu derlemede COVID-19'u literatür ışığında kardiyak tutulum açısından değerlendirmek istedik.

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Fulminant myocarditis and atrial fibrillation in child with acute COVID-19

Cited by 18 publications

References 19 publications

Clinical features and outcome of COVID‐19 positive children from a tertiary healthcare hospital in Karachi

Clinical features and outcome of COVID‐19 positive children from a tertiary healthcare hospital in Karachi

The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury

Çocuklarda Covi̇d-19 Enfeksi̇yonunda Kalp Tutulumu,

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