Fulminant myocarditis parvovirus B19 related in a young woman

Pesce, R; Taffarello, Pierpaolo; Rizzo, Stefania; Basso, Cristina; Cacciavillani, Luisa; Monte, Alvise Del; Babuin, Luciano; Gerosa, Gino; Bottio, Tomaso

doi:10.1007/s10047-021-01247-7

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…There are many case reports of pediatric myocarditis from parvovirus B19, but without any presenting arrhythmia [96][97][98]. In a case series of 3 patients with parvovirus B19 myocarditis, one patient presented with VT 2 weeks after suspected erythema infectiosum [99].…”

Section: Parvovirus B19mentioning

confidence: 99%

Cardiac arrhythmias in viral infections

Lee

Garan

Wan

et al. 2023

J Interv Card Electrophysiol

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Background The currentCOVID-19 pandemic has led to many studies examining its arrhythmogenic effects. However, there are many other viruses that are capable of inducing arrhythmias that have not received as much attention. The objective of this study was to review common viruses and identify studies highlighting their arrhythmogenic effects. Methods and resultsIn this review, we examined 15 viruses and the literature regarding their arrhythmogenic effects. The common mechanisms of action appear to be direct invasion of myocytes leading to immune mediated damage, infection of vascular endothelium, and alteration of cardiac ion channels. Conclusions This review highlights the growing evidence that supports the involvement of other viral infections in the development of arrhythmia. Physicians should be aware of these potentially life-threatening effects when caring for patients with these viruses, some of which are very common. Additional studies are required to better understand the complex mechanism and risk factors of cardiac arrhythmias in patients suffered from viral infections to determine whether the processes can be reversed or even prevented.

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Section: Parvovirus B19mentioning

confidence: 99%

Cardiac arrhythmias in viral infections

Lee

Garan

Wan

et al. 2023

J Interv Card Electrophysiol

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Fulminant Myocarditis Associated With Parvovirus B19 and Epstein-Barr Virus Coinfection

Yan,

Gupta,

Guido

et al. 2023

Infect Dis Clin Pract

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Parvovirus B19 (PVB19) and Epstein-Barr virus (EBV) commonly cause infection worldwide, with most persons infected during childhood. Their disease courses are usually mild and brief; however, PVB19 and EBV have been implicated as etiologies of viral myocarditis. We report a case of PVB19 and EBV coinfection associated with fulminant lymphocytic myocarditis. We address the implications of the case, including the differential diagnosis, immunomodulatory treatment considerations, and evidence for the pathologic roles of PVB19, EBV, and coinfection in myocarditis. Although the pathogenic roles of PVB19 or EBV alone in myocarditis are not well established, coinfection of PVB19 and EBV may unlock their pathogenic roles causing fulminant myocarditis. Treatment with steroids and intravenous immunoglobulin G in a patient with rapid clinical deterioration despite the presence of active infection on endomyocardial biopsy by polymerase chain reaction can result in a safe and quick recovery of fulminant viral myocarditis. Early and aggressive intervention, including both mechanical circulatory support and immunomodulatory therapy, may be key to improved outcomes in cases of fulminant myocarditis.

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